About: Hijacking of an autophagy-like process is critical for the life cycle of a DNA virus infecting oceanic algal blooms

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About: Hijacking of an autophagy-like process is critical for the life cycle of a DNA virus infecting oceanic algal blooms Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

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type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
title	Hijacking of an autophagy-like process is critical for the life cycle of a DNA virus infecting oceanic algal blooms
Creator	Ben-Dor, Shifra Rosenwasser, Shilo Sabanay, Helena Schatz, Daniella Shemi, Adva Vardi, Assaf Wolf, Sharon
source	PMC
abstract	Marine photosynthetic microorganisms are the basis of marine food webs and are responsible for nearly 50% of the global primary production. Emiliania huxleyi forms massive oceanic blooms that are routinely terminated by large double-stranded DNA coccolithoviruses. The cellular mechanisms that govern the replication cycle of these giant viruses are largely unknown. We used diverse techniques, including fluorescence microscopy, transmission electron microscopy, cryoelectron tomography, immunolabeling and biochemical methodologies to investigate the role of autophagy in host–virus interactions. Hallmarks of autophagy are induced during the lytic phase of E. huxleyi viral infection, concomitant with up-regulation of autophagy-related genes (ATG genes). Pretreatment of the infected cells with an autophagy inhibitor causes a major reduction in the production of extracellular viral particles, without reducing viral DNA replication within the cell. The host-encoded Atg8 protein was detected within purified virions, demonstrating the pivotal role of the autophagy-like process in viral assembly and egress. We show that autophagy, which is classically considered as a defense mechanism, is essential for viral propagation and for facilitating a high burst size. This cellular mechanism may have a major impact on the fate of the viral-infected blooms, and therefore on the cycling of nutrients within the marine ecosystem.
has issue date	2014-09-07(xsd:dateTime)
bibo:doi	10.1111/nph.13008
bibo:pmid	25195618
has license	cc-by
sha1sum (hex)	4ed270652370f2ffd9aecd7288519c77d7b925ea
schema:url	https://doi.org/10.1111/nph.13008
resource representing a document's title	Hijacking of an autophagy-like process is critical for the life cycle of a DNA virus infecting oceanic algal blooms
has PubMed Central identifier	PMC4233938
has PubMed identifier	25195618
schema:publication	New Phytol
resource representing a document's body	covid:4ed270652370f2ffd9aecd7288519c77d7b925ea#body_text
is schema:about of	named entity 'LIKE' named entity 'algal blooms' named entity 'DNA VIRUS' named entity 'NEARLY' named entity 'REPORT' named entity 'LIFE CYCLE' named entity 'INFECTING' named entity 'MARINE' named entity 'LARGE' named entity 'GLOBAL' named entity 'EMILIANIA HUXLEYI' named entity 'PROCESS' named entity 'DOUBLE-STRANDED DNA' named entity 'A DNA' named entity 'RAPID' named entity 'ALGAL BLOOMS' named entity 'CRITICAL' named entity 'AUTOPHAGY' named entity 'BASIS' named entity '50%' named entity 'GIANT VIRUSES' named entity 'MECHANISMS' named entity 'CELLULAR' named entity 'REPLICATION CYCLE' named entity 'FORMS' named entity 'MASSIVE' named entity 'TERMINATED' named entity 'PHOTOSYNTHETIC' named entity 'PRIMARY PRODUCTION' named entity 'FOOD WEBS' named entity 'THESE' named entity 'RESPONSIBLE' named entity 'MICROORGANISMS' named entity 'UNKNOWN' covid:arg/4ed270652370f2ffd9aecd7288519c77d7b925ea named entity 'mechanisms' named entity 'global' named entity 'giant viruses' named entity 'photosynthetic' named entity 'autophagy' named entity 'E. huxleyi' named entity 'autofluorescence' named entity 'Dreux' named entity 'E. huxleyi' named entity 'cell death' named entity '0.45' named entity 'infection' named entity 'incubation' named entity 'uranyl acetate' named entity 'autophagosomes' named entity 'wortmannin' named entity 'acclimation' named entity 'kDa' named entity 'nucleocytoplasmic large DNA virus' named entity 'Leica' named entity 'Phytoplankton' named entity 'cell death' named entity 'primers' named entity 'virus' named entity 'sphingolipids' named entity 'viral infection' named entity 'homologous' named entity 'E. huxleyi' named entity 'osmium tetroxide' named entity 'clade' named entity 'lytic' named entity 'membrane trafficking' named entity 'biochemical cascade' named entity 'Abcam' named entity 'multiplicity of infection' named entity 'phytoplankton' named entity 'virion' named entity 'dimethyl sulfoxide' named entity 'DMSO' named entity 'GE Healthcare'

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