About: IFITM proteins are incorporated onto HIV-1 virion particles and negatively imprint their infectivity

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About: IFITM proteins are incorporated onto HIV-1 virion particles and negatively imprint their infectivity Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	IFITM proteins are incorporated onto HIV-1 virion particles and negatively imprint their infectivity
Creator	Appourchaux, Romain Beaumont, Elodie Berger, Gregory Brand, Denys Cimarelli, Andrea Durand, Stéphanie Gaillard, Julien Mahieux, Renaud Nguyen, Xuan-Nhi Roch, Emmanuelle Roingeard, Philippe Tartour, Kevin Turpin, Jocelyn
Source	Medline; PMC
abstract	BACKGROUND: Interferon induced transmembrane proteins 1, 2 and 3 (IFITMs) belong to a family of highly related antiviral factors that have been shown to interfere with a large spectrum of viruses including Filoviruses, Coronaviruses, Influenza virus, Dengue virus and HIV-1. In all these cases, the reported mechanism of antiviral inhibition indicates that the pool of IFITM proteins present in target cells blocks incoming viral particles in endosomal vesicles where they are subsequently degraded. RESULTS: In this study, we describe an additional mechanism through which IFITMs block HIV-1. In virus-producing cells, IFITMs coalesce with forming virions and are incorporated into viral particles. Expression of IFITMs during virion assembly leads to the production of virion particles of decreased infectivity that are mostly affected during entry in target cells. This mechanism of inhibition is exerted against different retroviruses and does not seem to be dependent on the type of Envelope present on retroviral particles. CONCLUSIONS: The results described here identify a novel mechanism through which IFITMs affect HIV-1 infectivity during the late phases of the viral life cycle. Put in the context of data obtained by other laboratories, these results indicate that IFITMs can target HIV at two distinct moments of its life cycle, in target cells as well as in virus-producing cells. These results raise the possibility that IFITMs could similarly affect distinct steps of the life cycle of a number of other viruses. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (doi:10.1186/s12977-014-0103-y) contains supplementary material, which is available to authorized users.
has issue date	2014-11-25(xsd:dateTime)
bibo:doi	10.1186/s12977-014-0103-y
bibo:pmid	25422070
has license	cc-by
sha1sum (hex)	4ef4cb3ed4814b1afceebb92b410e53fd5646f4e
schema:url	https://doi.org/10.1186/s12977-014-0103-y
resource representing a document's title	IFITM proteins are incorporated onto HIV-1 virion particles and negatively imprint their infectivity
has PubMed Central identifier	PMC4251951
has PubMed identifier	25422070
schema:publication	Retrovirology
resource representing a document's body	covid:4ef4cb3ed4814b1afceebb92b410e53fd5646f4e#body_text
is schema:about of	named entity 'HIV-1' named entity 'Influenza virus' named entity 'family' named entity 'HIV-1' named entity 'ANTIVIRAL' named entity 'THE POOL' named entity 'DEGRADED' named entity 'VIRAL PARTICLES' named entity 'CASES' named entity 'HIGHLY' named entity 'FILOVIRUSES' named entity 'RELATED' named entity 'DENGUE VIRUS' named entity 'FAMILY' named entity 'REPORTED' named entity 'WHERE' named entity 'INTERFERE' named entity 'PRESENT' named entity 'BACKGROUND' named entity 'PROTEINS' named entity 'CORONAVIRUSES' named entity 'INHIBITION' named entity 'IMPRINT' named entity 'VIRUSES' covid:arg/4ef4cb3ed4814b1afceebb92b410e53fd5646f4e named entity 'HAVE' named entity 'PARTICLES' named entity 'THEIR' named entity 'VIRION' named entity 'PROTEINS' named entity 'INFECTIVITY' named entity 'TARGET CELLS' named entity 'INCOMING' named entity 'THESE' named entity 'VESICLES' named entity 'HIV-1' named entity 'INCLUDING' named entity 'MECHANISM' named entity 'INFLUENZA VIRUS' named entity 'SPECTRUM' named entity 'BLOCKS' named entity 'LARGE' named entity 'endosomal' named entity 'highly' named entity 'viral' named entity 'mechanism' named entity 'degraded' named entity 'HEK293T' named entity 'uranyl acetate' named entity 'HIV-1' named entity 'IFNα' named entity 'GM-CSF' named entity 'N-term' named entity 'GFP' named entity 'HIV-1' named entity 'anti-Flag' named entity 'virion particles' named entity 'HEK293T' named entity 'Virions' named entity 'virions' named entity 'CD45' named entity 'trypsin' named entity 'infectivity' named entity 'infectivity' named entity 'shRNAs' named entity 'myeloid cells' named entity 'exogenous' named entity 'IFNα' named entity 'DAPI'

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