About: PEDV ORF3 Independently Regulates IκB Kinase β-Mediated NF-κB and IFN-β Promoter Activities

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About: PEDV ORF3 Independently Regulates IκB Kinase β-Mediated NF-κB and IFN-β Promoter Activities Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	PEDV ORF3 Independently Regulates IκB Kinase β-Mediated NF-κB and IFN-β Promoter Activities
Creator	Jongkaewwattana, Anan Koonpaew, Surapong Jaru-Ampornpan, Peera Srisutthisamphan, Kanjana Kaewborisuth, Challika Viriyakitkosol, Ratchanont
Source	Medline; PMC
abstract	The Open Reading Frame 3 (ORF3), an accessory protein of porcine epidemic diarrhea virus (PEDV), has been shown to interact with a myriad of cellular proteins, among which include the IκB kinase β (IKBKB). Here, specific IKBKB domains responsible for ORF3–IKBKB interaction were identified. Dysregulation of NF-κB and Type I interferon (IFN) in the presence of ORF3 was also demonstrated. We showed that while ORF3 was capable of up-regulating IKBKB-meditated NF-κB promoter activity, it surprisingly down-regulated the activation of IKBKB-meditated IFN-β promoter and expression of IFN-β mRNA. When overexpressed, ORF3 could suppress Poly I:C mediated type I IFN production and induction. Finally, we demonstrated that IKBKB- and RIG-I-mediated type I IFN induction by ORF3 resulted in different outcomes. Our study is the first to demonstrate the potential and complex roles of ORF3 in the involvement of aberrant immune signaling as well as in the virus–host interaction.
has issue date	2020-05-14(xsd:dateTime)
bibo:doi	10.3390/pathogens9050376
bibo:pmid	32423021
has license	cc-by
sha1sum (hex)	4f0a6bf3cff2a84f244e6dd00299f653b3ba2348
schema:url	https://doi.org/10.3390/pathogens9050376
resource representing a document's title	PEDV ORF3 Independently Regulates IκB Kinase β-Mediated NF-κB and IFN-β Promoter Activities
has PubMed Central identifier	PMC7281231
has PubMed identifier	32423021
schema:publication	Pathogens
resource representing a document's body	covid:4f0a6bf3cff2a84f244e6dd00299f653b3ba2348#body_text
is schema:about of	named entity 'study' named entity 'interact' named entity 'potential' named entity 'INVOLVEMENT' named entity 'VIRUS-HOST INTERACTION' named entity 'CELLULAR' named entity 'REGULATING' covid:arg/4f0a6bf3cff2a84f244e6dd00299f653b3ba2348 named entity 'demonstrated' named entity 'Our' named entity 'aberrant' named entity 'firefly luciferase' named entity 'mRNA expression' named entity 'plasmids' named entity 'type I interferon' named entity 'IKBKB' named entity 'IKBKB' named entity 'anti-viral' named entity 'inoculated' named entity 'immune modulation' named entity 'supernatant' named entity 'IRF1' named entity 'lysed' named entity 'NF-κB' named entity 'mRNA' named entity 'phosphorylation' named entity 'anti-Flag' named entity 'PEDV' named entity 'proinflammatory cytokines' named entity 'type I interferon' named entity 'spectrophotometer' named entity 'IKBKB' named entity 'mRNA' named entity 'type I IFN' named entity 'TBK1' named entity 'IKBKB' named entity '3C-like protease' named entity 'IFN-α/β' named entity 'receptor' named entity 'IKBKB' named entity 'IKBKB' named entity 'PEDV' named entity 'IKBKB' named entity 'Non-structural protein' named entity 'type I IFN' named entity 'nucleus' named entity 'nonstructural protein 3' named entity 'HEK' named entity 'IKBKB' named entity 'syncytium' named entity 'nonstructural protein' named entity 'type I IFN' named entity 'nucleocapsid' named entity 'antibody' named entity 'IκB' named entity 'recombinant' named entity 'wild-type' named entity 'host cells' named entity 'down-regulated' named entity 'proinflammatory cytokine' named entity 'antiviral' named entity 'down-regulate' named entity 'Thermo Scientific' named entity 'scaffold' named entity 'interferon' named entity 'Phosphorylation' named entity 'nsP3' named entity 'IKBKB' named entity 'alkaline phosphatase' named entity 'type I IFN' named entity 'PBS' named entity 'recombinant' named entity 'up-regulation' named entity 'IKBKB' named entity 'interact' named entity 'plasmid'

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