About: IFITM3: How genetics influence influenza infection demographically

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An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
title	IFITM3: How genetics influence influenza infection demographically
Creator	Dong, Tao Wellington, Dannielle Abdel-Haq, Adi Laurenson-Schafer, Henry
source	Medline; PMC
abstract	The role of host genetics in influenza infection is unclear despite decades of interest. Confounding factors such as age, sex, ethnicity and environmental factors have made it difficult to assess the role of genetics without influence. In recent years a single nucleotide polymorphism, interferon-induced transmembrane protein 3 (IFITM3) rs12252, has been shown to alter the severity of influenza infection in Asian populations. In this review we investigate this polymorphism as well as several others suggested to alter the host's defence against influenza infection. In addition, we highlight the open questions surrounding the viral restriction protein IFITM3 with the hope that by answering some of these questions we can elucidate the mechanism of IFITM3 viral restriction and therefore how this restriction is altered due to the rs12252 polymorphism.
has issue date	2019-03-20(xsd:dateTime)
bibo:doi	10.1016/j.bj.2019.01.004
bibo:pmid	30987701
has license	cc-by-nc-nd
sha1sum (hex)	4f16c5332bacc7ebdc6286893771ce195dd270de
schema:url	https://doi.org/10.1016/j.bj.2019.01.004
resource representing a document's title	IFITM3: How genetics influence influenza infection demographically
has PubMed Central identifier	PMC6468115
has PubMed identifier	30987701
schema:publication	Biomed J
resource representing a document's body	covid:4f16c5332bacc7ebdc6286893771ce195dd270de#body_text
is schema:about of	named entity 'INFLUENZA INFECTION' named entity 'GENETICS' named entity 'IFITM3' named entity 'HOW' named entity 'INFLUENCE' named entity 'infection' named entity 'influence' named entity 'Asian' named entity 'IAV' named entity 'cytoplasmic' named entity 'infection' named entity 'antiviral' named entity 'IFITM3' named entity 'immunosenescence' named entity 'cytomegalovirus' named entity 'influenza A virus' named entity '1918 pandemic' named entity 'infection' named entity 'IFN' named entity 'ethnicity' named entity 'MAF' named entity 'SNPs' named entity 'viral entry' named entity 'HIV-1' named entity 'mortality rate' named entity 'protein' named entity 'IFITM3' named entity 'activation site' named entity 'gamma-interferon' named entity 'early endosomes' named entity 'chromosome' named entity 'influenza' named entity 'viral tropism' named entity 'TLR2' named entity 'LAMP2' named entity 'European populations' named entity 'homologous' named entity 'IFITM3' named entity 'IFN' named entity 'influenza infection' named entity 'clinical samples' named entity 'Canada' named entity 'IFITM3' named entity 'exon' named entity 'influenza infection' named entity 'homology' named entity 'Surfactant' named entity 'IFN-a' named entity 'antiviral' named entity 'SNPs' named entity 'ethnicity' named entity 'cohort studies' named entity 'Mouse embryonic fibroblasts' named entity 'IFITM3' named entity 'East Asian' named entity 'transmembrane protein' named entity 'endosomal' named entity 'Transmembrane' named entity 'SNPs' named entity 'ubiquitination' named entity 'socioeconomic' named entity 'IFITM3' named entity 'European populations' named entity 'endosomal pathway' named entity 'CD63' named entity 'IFITM3' named entity 'influenza virus' named entity 'allele frequencies' named entity 'protein structure' named entity 'genetic variation' named entity 'Asian' named entity 'homozygosity' named entity 'ethnicity' named entity 'IFITM3' named entity 'IAV' named entity 'Mx1' named entity 'neural development' named entity 'risk of death'

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