About: Delayed-type hypersensitivity response in the central nervous system during JHM virus infection requires viral specificity for protection

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About: Delayed-type hypersensitivity response in the central nervous system during JHM virus infection requires viral specificity for protection Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Delayed-type hypersensitivity response in the central nervous system during JHM virus infection requires viral specificity for protection
Creator	Shubin, Richard Stohlman, Stephen Sussman, Mark Erlich, Stephanie Matsushima, Glenn
Source	Elsevier; Medline; PMC
abstract	Abstract The JHM strain of mouse hepatitis virus (JHMV) elicits an I-A-restricted delayed-type hypersensitivity (DTH) response mediated by a Thy-1+, Lyt-1+, and CD4+ T cell. Adoptive transfer of these polyclonal CD4+ T cells from immunized mice prevents death in lethally infected recipients without significantly reducing virus titer in the central nervous system (CNS). These observations raise the possibility that the recruitment of mononuclear cells into the CNS may play a critical role in survival from a lethal CNS infection. Transient DTH response to nonviral antigens induced an accumulation of monocytes in the CNS that was maximal at 48 h post-challenge and virtually resolved by 5 days post-challenge. By contrast the induction of prolonged DTH responses resulted in the accumulation of a large number monocytes that persisted in the CNS for at least 5 days post-challenge. Neither type of DTH reaction suppressed virus replication or prevented death from concomitant lethal JHMV infection.
has issue date	1988-09-30(xsd:dateTime)
bibo:doi	10.1016/0165-5728(88)90007-0
bibo:pmid	2842378
has license	els-covid
sha1sum (hex)	4f26308cc44a1ed7a049f3eaf8dc2c24c9cfbd38
schema:url	https://doi.org/10.1016/0165-5728%2888%2990007-0
resource representing a document's title	Delayed-type hypersensitivity response in the central nervous system during JHM virus infection requires viral specificity for protection
has PubMed Central identifier	PMC7119880
has PubMed identifier	2842378
schema:publication	Journal of Neuroimmunology
resource representing a document's body	covid:4f26308cc44a1ed7a049f3eaf8dc2c24c9cfbd38#body_text
is schema:about of	named entity 'raise' named entity 'cells' named entity 'response' named entity 'reaction' named entity 'POLYCLONAL' named entity 'POST' named entity 'MOUSE HEPATITIS VIRUS' named entity 'RESOLVED' named entity 'PREVENTS' named entity 'ADOPTIVE TRANSFER' named entity 'SURVIVAL' named entity 'PLAY' named entity 'ROLE' covid:arg/4f26308cc44a1ed7a049f3eaf8dc2c24c9cfbd38 named entity 'POSSIBILITY' named entity 'THESE' named entity 'DEATH' named entity 'IMMUNIZED' named entity 'MONOCYTES' named entity 'RESPONSES' named entity 'SUPPRESSED' named entity 'NUMBER OF' named entity 'ELICITS' named entity 'INDUCED' named entity 'T CELL' named entity 'CD4' named entity 'MICE' named entity 'VIRUS REPLICATION' named entity 'INFECTION' named entity 'RESPONSE TO' named entity 'REDUCING' named entity 'DELAYED-TYPE HYPERSENSITIVITY' named entity 'DELAYED-TYPE HYPERSENSITIVITY RESPONSE' named entity 'VIRAL' named entity 'CNS' named entity 'CONTRAST' named entity 'RESTRICTED' named entity 'NEITHER TYPE' named entity 'DTH' named entity 'CONCOMITANT' named entity 'INFECTED' named entity 'VIRUS INFECTION' named entity 'OBSERVATIONS' named entity 'RESPONSE' named entity 'RECRUITMENT' named entity 'CHALLENGE' named entity 'TRANSIENT' named entity 'CENTRAL NERVOUS SYSTEM' named entity 'PROTECTION' named entity 'CENTRAL NERVOUS SYSTEM' named entity 'T CELLS' named entity 'PROLONGED' named entity 'INDUCTION' named entity 'LARGE' named entity 'ACCUMULATION' named entity 'DAYS' named entity 'CNS INFECTION' named entity 'TITER' named entity 'CRITICAL' named entity 'THY' named entity 'REACTION' named entity 'ANTIGENS' named entity 'MEDIATED' named entity 'LETHAL' named entity 'STRAIN' named entity 'MONONUCLEAR CELLS' named entity 'MAXIMAL' named entity 'VIRUS' named entity 'LYT-1' named entity 'SPECIFICITY' named entity 'prevented' named entity 'infection' named entity 'antigens' named entity 'critical role' named entity 'accumulation' named entity 'mouse' named entity 'Neither'

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