About: siRNA and the lung: research tool or therapeutic drug?

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An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	siRNA and the lung: research tool or therapeutic drug?
Creator	Novobrantseva, Tatiana De Fougerolles, Antonin Donnelly, Louise Rogers, Duncan
Source	Elsevier; Medline; PMC
abstract	Oligonucleotide-based therapeutics have been hailed as ‘the next great wave of the biotechnology revolution’ starting with antisense oligonucleotides (ASOs) nearly 20 years ago to RNA interference (RNAi) currently. Is RNAi just the latest research tool or does it have real potential as a therapeutic drug modality? As a research tool, it is evident that RNAi has revolutionized the biological sciences by allowing selective silencing of messenger RNA (mRNA) expression. With the advent of the postgenomic era, RNAi offers a therapeutic platform on which to identify potential picomolar active drug candidates to any target, including those that are conventionally undruggable. In this review, we will discuss the progress made in developing RNAi therapeutics for the treatment of respiratory diseases.
has issue date	2008-05-14(xsd:dateTime)
bibo:doi	10.1016/j.coph.2008.04.005
bibo:pmid	18485820
has license	no-cc
sha1sum (hex)	4f2a85b1db98c4c98ec761e9df10bb429fd95134
schema:url	https://doi.org/10.1016/j.coph.2008.04.005
resource representing a document's title	siRNA and the lung: research tool or therapeutic drug?
has PubMed Central identifier	PMC7106383
has PubMed identifier	18485820
schema:publication	Curr Opin Pharmacol
resource representing a document's body	covid:4f2a85b1db98c4c98ec761e9df10bb429fd95134#body_text
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