About: Pneumonia in children admitted to the national referral hospital in Bhutan: A prospective cohort study

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Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Pneumonia in children admitted to the national referral hospital in Bhutan: A prospective cohort study
Creator	Muñoz-Almagro, Carmen Bassat, Quique Jullien, Sophie Pradhan, Dinesh Dema, Kumbu Garcia-Garcia, Selene Ribó, Jose Sharma, Ragunath Tshering, Tashi Gyalpo, Khesar Jigme, B Kgumsb, Bhutan Lam, Gongphel Lam, Menkhang Referral, National Wangchuck, Dorji
Source	Elsevier; Medline; PMC
abstract	OBJECTIVES: The study aim was to describe the etiological profile and clinical characteristics of pneumonia among children hospitalized in Thimphu, Bhutan. METHODS: This prospective study enrolled children aged 2–59 months admitted to the Jigme Dorji Wangchuck National Referral Hospital with World Health Organization (WHO)-defined clinical pneumonia. Demographic and clinico-radiological data were collected through questionnaires, physical examination, and chest radiography. Blood samples and nasopharyngeal washing were collected for microbiological analysis including culture and molecular methods. RESULTS: From July 2017 to June 2018, 189 children were enrolled, of which 53.4% were infants. Pneumonia-related admissions were less frequent over the winter. Chest radiographies were obtained in 149 children; endpoints included pneumonia in 39 cases (26.2%), other infiltrates in 31 (20.8%), and were normal in 79 children (53.0%). Non-contaminated bacterial growth was detected in 8/152 (5.3%) blood cultures, with only two cases of Streptococcus pneumoniae. Viral detection in upper respiratory secretions was common, with at least one virus detected in 103/115 (89.6%). The three most-commonly isolated viruses were respiratory syncytial virus (52/115; 45.2%), rhinovirus (42/115; 36.5%), and human parainfluenza virus (19/115; 16.5%). A third of patients with viral infections showed mixed infections. Case fatality rate was 3.2% (6/189). CONCLUSION: Respiratory viral infections predominated among this cohort of WHO-defined clinical pneumonia cases, whereas bacterial aetiologies were uncommon, highlighting the epidemiologic transition that Bhutan seems to have reached.
has issue date	2020-04-10(xsd:dateTime)
bibo:doi	10.1016/j.ijid.2020.04.017
bibo:pmid	32283281
has license	no-cc
sha1sum (hex)	4f2fae368f11424bc2520cbdb2ca4d8955d5c710
schema:url	https://doi.org/10.1016/j.ijid.2020.04.017
resource representing a document's title	Pneumonia in children admitted to the national referral hospital in Bhutan: A prospective cohort study
has PubMed Central identifier	PMC7195124
has PubMed identifier	32283281
schema:publication	Int J Infect Dis
resource representing a document's body	covid:4f2fae368f11424bc2520cbdb2ca4d8955d5c710#body_text
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