About: Increased Systemic Cytokine/Chemokine Expression in Asthmatic and Non‐asthmatic Patients with Bacterial, Viral or Mixed Lung Infection

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About: Increased Systemic Cytokine/Chemokine Expression in Asthmatic and Non‐asthmatic Patients with Bacterial, Viral or Mixed Lung Infection Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Increased Systemic Cytokine/Chemokine Expression in Asthmatic and Non‐asthmatic Patients with Bacterial, Viral or Mixed Lung Infection
Creator	Alvarez-Mon, M Arocha, F Bermudez, J Chacín, B Duran, A Espina, L Giuffrida, M Gotera, J Mavarez, A Mosquera, J Valero, N
Source	Medline; PMC
abstract	This study was aimed to determine the profiles of serum cytokines (IL‐1β, TNF‐α, IL‐4, IL‐5) and chemokines (MCP‐1: monocyte chemoattract protein‐1 and RANTES: regulated on activation normal T cell expressed and secreted) in individuals with an asthmatic versus a non‐asthmatic background with bacterial, viral or mixed acute respiratory infection. Asthmatic (n = 14) and non‐asthmatic (n = 29) patients with acute viral, bacterial or mixed (bacterial and viruses) respiratory infection were studied. Patients were also analysed as individuals with pneumonia or bronchitis. Healthy individuals with similar age and sex (n = 10) were used as controls. Cytokine/chemokine content in serum was determined by ELISA. Increased cytokine/chemokine concentration in asthmatic and non‐asthmatic patients was observed. However, higher concentrations of chemokines (MCP‐1 and RANTES) in asthmatic patients infected by viruses, bacteria or bacteria and viruses (mixed) than in non‐asthmatic patients were observed. In general, viral and mixed infections were better cytokine/chemokine inducers than bacterial infection. Cytokine/chemokine expression was similarly increased in both asthmatic and non‐asthmatic patients with pneumonia or bronchitis, except that RANTES remained at normal levels in bronchitis. Circulating cytokine profiles induced by acute viral, bacterial or mixed lung infection were not related to asthmatic background, except for chemokines that were increased in asthmatic status.
has issue date	2017-03-30(xsd:dateTime)
bibo:doi	10.1111/sji.12532
bibo:pmid	28168862
has license	no-cc
sha1sum (hex)	4f4a8752a2ef596860d90ef31a71f2f63c2dc94a
schema:url	https://doi.org/10.1111/sji.12532
resource representing a document's title	Increased Systemic Cytokine/Chemokine Expression in Asthmatic and Non‐asthmatic Patients with Bacterial, Viral or Mixed Lung Infection
has PubMed Central identifier	PMC7169570
has PubMed identifier	28168862
schema:publication	Scand J Immunol
resource representing a document's body	covid:4f4a8752a2ef596860d90ef31a71f2f63c2dc94a#body_text
is schema:about of	named entity 'MIXED' named entity 'PROTEIN' named entity 'RESPIRATORY INFECTION' named entity 'NON-' named entity 'SERUM' named entity 'BACTERIAL' named entity 'PNEUMONIA' named entity 'BACKGROUND' named entity 'HIGHER' named entity 'mixed infections' named entity 'Cytokine' named entity 'MCP-1' named entity 'asthmatic' named entity 'pneumonia' named entity 'asthmatic' named entity 'RANTES' named entity 'bacterial infection' named entity 'chemokine' named entity 'asthmatic' named entity 'Cytokine' named entity 'lung infection' named entity 'chemokine' named entity 'viruses' named entity 'Lung Infection' named entity 'Cytokine' named entity 'asthmatic' named entity 'respiratory infection' named entity 'human bocavirus' named entity 'TNF-a' named entity 'MCP-1' named entity 'chest radiography' named entity 'asthmatic' named entity 'eosinophil' named entity '1, 2' named entity 'asthmatic' named entity 'leucocyte' named entity 'MCP-1' named entity 'adenoviruses' named entity 'non-atopic' named entity 'asthmatic' named entity 'asthmatic' named entity 'chest radiography' named entity 'infection' named entity 'human metapneumovirus' named entity 'respiratory infection' named entity 'TNF-a' named entity 'respiratory infection' named entity 'tachypnea' named entity 'asthmatic' named entity 'chemokines' named entity 'cytokine' named entity 'atypical bacteria' named entity 'MCP-1' named entity 'asthmatic' named entity 'tumour necrosis factor-alpha' named entity 'cytokine' named entity 'dyspnoea' named entity 'IL-4' named entity 'cell growth' named entity 'eosinophils' named entity 'cytokine' named entity 'mixed infection' named entity 'Monocyte chemoattractant protein-1' named entity 'IL-5' named entity 'micro-organisms' named entity 'IL-4' named entity 'microbial' named entity 'RANTES' named entity 'RANTES' named entity 'IL-4' named entity 'myalgia'

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