About: Biological and macromolecular properties of murine cells persistently infected with MHV-JHM

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About: Biological and macromolecular properties of murine cells persistently infected with MHV-JHM Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Biological and macromolecular properties of murine cells persistently infected with MHV-JHM
Creator	Leibowitz, J Anderson, K Bo~d, C Goss, Susan
Source	PMC
abstract	A persistently-infected neuroblastoma culture [Neuro-2A (JHMV)] was established with the murine hepatitis virus JHM [MHV-JHM]. After 100 days of passage, the endogenous virus [Neuro-2A (JHMV) end] released by this culture was unable to induce the syncytia typical of MHV-JHM and the endogenous virus was not temperature-sensitive. The Neuro-2A (JHMV) culture was cured of virus production by passage under neutralizing antibody [Neuro-2A (JHMV) Ab]. The Neuro-2A (JHMV) and the Neuro-2A (JHMV) Ab cultures were as susceptible to heterologous infection with mengovirus and vesicular stomatitis virus as the uninfected Neuro-2A culture. However, the Neuro-2A (JHMV) and Neuro-2A (JHMV) Ab cultures were partially resistant to homologous superinfection by MHV-JHM and the closely related MHV-A59. Virus related to MHV-JHM was rescued from the antibody-cured cells by cell fusion. The synthesis of MHV-JHM specific antigens by Neuro-2A (JHMV) cells, Neuro-2A (JHMV) Ab cells and 17 Cl-1 cells infected by Neuro-2A (JHMV) end was studied by SDS-PAGE. The genomic RNAs of MHV-JHM and Neuro-2A (JHMV) end were compared by oligonucleotide mapping. The results of the protein and RNA studies indicated that the genome of Neuro-2A (JHMV) end was substantially modified from the genome of MHV-JHM, but the modifications did not significantly alter the molecular size of the viral-specific proteins.
has issue date	1984-01-01(xsd:dateTime)
bibo:doi	10.1007/bf01311222
bibo:pmid	6329142
has license	no-cc
sha1sum (hex)	4f58ba92c5fcce5d97aa1cf882941a959768ab8d
schema:url	https://doi.org/10.1007/bf01311222
resource representing a document's title	Biological and macromolecular properties of murine cells persistently infected with MHV-JHM
has PubMed Central identifier	PMC7086878
has PubMed identifier	6329142
schema:publication	Arch Virol
resource representing a document's body	covid:4f58ba92c5fcce5d97aa1cf882941a959768ab8d#body_text
is schema:about of	named entity 'DAYS' named entity 'CURED' named entity 'SUPERINFECTION' named entity 'MOLECULAR SIZE' named entity 'VIRUS PRODUCTION' named entity 'PROTEINS' named entity 'SDS-PAGE' named entity 'VIRUS' named entity 'Neuro' named entity 'cells' named entity 'infected' named entity 'Neuro' named entity 'However' named entity 'Properties' named entity 'ARCHIVES' named entity 'ANTIBODY' named entity 'DID' named entity 'COMPARED' named entity 'ESTABLISHED' named entity 'PERSISTENTLY' named entity 'MURINE' named entity 'INFECTED' named entity 'UNINFECTED' named entity 'NEUROBLASTOMA' named entity 'GENOME' named entity 'SPECIFIC' named entity 'T00' named entity 'CULTURE' named entity 'MURINE HEPATITIS VIRUS' named entity 'NEURO-2A' named entity 'NEUTRALIZING ANTIBODY' named entity 'CELL FUSION' named entity 'INFECTION' named entity 'MHV' named entity 'BIOLOGICAL' named entity 'PROPERTIES' named entity 'HOMOLOGOUS' named entity 'MODIFIED' named entity 'SYNCYTIA' named entity 'HETEROLOGOUS' named entity 'SYNTHESIS' named entity 'PROTEIN ' named entity 'RESISTANT TO' named entity 'BUT' named entity 'INDICATED' named entity 'INDUCE' named entity 'CELLS' named entity 'VIROLOGY' named entity 'TEMPERATURE-SENSITIVE' named entity 'PASSAGE' named entity 'RNA' named entity 'ALTER' named entity 'RNAS' named entity 'MAPPING' named entity 'RELATED' named entity 'INFECTED' named entity 'ENDOGENOUS' named entity 'MENGOVIRUS' named entity 'GENOMIC' named entity 'SUSCEPTIBLE' named entity 'A59' named entity 'RESULTS' named entity 'RELEASED' named entity 'SPECIFIC ANTIGENS' named entity 'VESICULAR STOMATITIS VIRUS' named entity 'CELLS' named entity 'TYPICAL' named entity 'PERSISTENTLY' named entity 'END' named entity 'STUDIES' covid:arg/4f58ba92c5fcce5d97aa1cf882941a959768ab8d named entity 'Neuro' named entity 'endogenous' named entity 'cell fusion' named entity 'studied' named entity 'studies' named entity 'genomic' named entity 'Neuro'

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