About: A self-adjuvanted nanoparticle based vaccine against infectious bronchitis virus

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About: A self-adjuvanted nanoparticle based vaccine against infectious bronchitis virus Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	A self-adjuvanted nanoparticle based vaccine against infectious bronchitis virus
Creator	Burkhard, Peter Li, Jianping Garmendia, Antonio Girshick, Theodore Mishra, Neha Helal, Zeinab Khan, Mazhar Karch,
Source	Medline; PMC
abstract	Infectious bronchitis virus (IBV) affects poultry respiratory, renal and reproductive systems. Currently the efficacy of available live attenuated or killed vaccines against IBV has been challenged. We designed a novel IBV vaccine alternative using a highly innovative platform called Self-Assembling Protein Nanoparticle (SAPN). In this vaccine, B cell epitopes derived from the second heptad repeat (HR2) region of IBV spike proteins were repetitively presented in its native trimeric conformation. In addition, flagellin was co-displayed in the SAPN to achieve a self-adjuvanted effect. Three groups of chickens were immunized at four weeks of age with the vaccine prototype, IBV-Flagellin-SAPN, a negative-control construct Flagellin-SAPN or a buffer control. The immunized chickens were challenged with 5x10(4.7) EID50 IBV M41 strain. High antibody responses were detected in chickens immunized with IBV-Flagellin-SAPN. In ex vivo proliferation tests, peripheral mononuclear cells (PBMCs) derived from IBV-Flagellin-SAPN immunized chickens had a significantly higher stimulation index than that of PBMCs from chickens receiving Flagellin-SAPN. Chickens immunized with IBV-Flagellin-SAPN had a significant reduction of tracheal virus shedding and lesser tracheal lesion scores than did negative control chickens. The data demonstrated that the IBV-Flagellin-SAPN holds promise as a vaccine for IBV.
has issue date	2018-09-14(xsd:dateTime)
bibo:doi	10.1371/journal.pone.0203771
bibo:pmid	30216376
has license	cc-by
sha1sum (hex)	4fc79293e3efdfd44b408d923b2448ac6a5ddd0d
schema:url	https://doi.org/10.1371/journal.pone.0203771
resource representing a document's title	A self-adjuvanted nanoparticle based vaccine against infectious bronchitis virus
has PubMed Central identifier	PMC6138407
has PubMed identifier	30216376
schema:publication	PLoS One
resource representing a document's body	covid:4fc79293e3efdfd44b408d923b2448ac6a5ddd0d#body_text
is schema:about of	named entity 'immunized' named entity 'immunized' named entity 'control' named entity 'reproductive systems' named entity 'SELF' named entity 'INDEX' named entity 'RECEIVING' named entity 'ADJUVANTED' named entity 'CONFORMATION' named entity 'ALTERNATIVE' named entity 'EFFECT' named entity 'NEGATIVE CONTROL' named entity 'MONONUCLEAR CELLS' named entity 'DETECTED' named entity 'EPITOPES' named entity 'VIRUS SHEDDING' named entity 'REGION' named entity 'USING' named entity 'DISPLAYED' named entity 'POULTRY' named entity 'PERIPHERAL' named entity 'RENAL' named entity 'REPEAT' named entity 'PROMISE' named entity 'LESSER' named entity 'TRACHEAL' named entity 'SPIKE' named entity 'HIGH' named entity 'SCORES' named entity 'ANTIBODY' named entity 'BUFFER CONTROL' named entity 'VACCINES' named entity 'EFFICACY' named entity 'NEGATIVE' named entity 'EID50' named entity 'EX VIVO' named entity 'SIGNIFICANT' named entity 'TRACHEAL LESION' named entity 'RESPIRATORY' named entity 'VACCINE' named entity 'SECOND' named entity 'WEEKS' named entity 'B CELL' named entity 'DEMONSTRATED' named entity 'PLATFORM' named entity 'PROTOTYPE' named entity 'PROLIFERATION' named entity 'PRESENTED' named entity 'SELF' named entity 'INFECTIOUS BRONCHITIS VIRUS' named entity 'NANOPARTICLE' named entity 'DID' named entity 'PBMCS' named entity 'NATIVE' named entity 'ITS' named entity 'ATTENUATED' named entity 'FLAGELLIN' named entity 'NANOPARTICLE' named entity 'VACCINE' named entity 'GROUPS' named entity 'LIVE' named entity 'ADDITION' named entity 'DERIVED' named entity 'PROTEINS' named entity 'AVAILABLE' named entity 'CURRENTLY' named entity 'IMMUNIZED' named entity 'TESTS' named entity 'STIMULATION' named entity 'STRAIN' named entity 'ADJUVANTED' named entity 'REDUCTION' named entity 'DATA' named entity 'HIGHLY'

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