About: Pathogenesis of virus-induced immune-mediated demyelination

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An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Pathogenesis of virus-induced immune-mediated demyelination
Creator	Kang, Bong-Su Kang, Hee-Kap Kim, Byung Lee, Hee-Gu Lyman, Michael Mohindru, Mani Palma, Joann
Source	Medline; PMC
abstract	Theiler's murine encephalomyelitis virus-induced demyelinating disease has been extensively studied as an attractive infectiousmodel for human multiple sclerosis. Virus-specific inflammatory Th1 cell responses followed by autoimmune responses to myelin antigens play a crucial role in the pathogenic processes leading to demyelination. Antibody and cytotoxic T cells (CTL) responses to virus appears to be primarily protective from demyelinating disease. Although the role of Th1 and CTL responses in the induction of demyelinating disease is controversial, assessment of cytokine sproduced locally in the central nervous system (CNS) during the course of disease and the effects of altered inflammatory cytokine levels strongly support the importance of Th1 responses in this virus-induced demyelinating disease. Induction of various chemokines and cytokines in different glial and antigen presenting cells upon viral infection appears to be an important initiation mechanism for inflammatory Th1 responses in the CNS. Coupled with the initial inflammatory responses, viral persistence in the CNS may be acritical factor for sustaining inflammatory responses and consequent immune-mediated demyelinating disease.
has issue date	2001-01-01(xsd:dateTime)
bibo:doi	10.1385/ir:24:2:121
bibo:pmid	11594451
has license	no-cc
sha1sum (hex)	5059b489093b6dd4480b03d0644e89ee739c7785
schema:url	https://doi.org/10.1385/ir:24:2:121
resource representing a document's title	Pathogenesis of virus-induced immune-mediated demyelination
has PubMed Central identifier	PMC7091353
has PubMed identifier	11594451
schema:publication	Immunol Res
resource representing a document's body	covid:5059b489093b6dd4480b03d0644e89ee739c7785#body_text
is schema:about of	named entity 'VIRUS' named entity 'consequent' named entity 'disease' named entity 'MURINE ENCEPHALOMYELITIS VIRUS' named entity 'LOCALLY' named entity 'VIRUS' named entity 'CRITICAL FACTOR' named entity 'TH1' named entity 'MODEL' named entity 'PATHOGENESIS' named entity 'PLAY' named entity 'IMPORTANT' named entity 'SUPPORT' named entity 'IMMUNE-MEDIATED' named entity 'RESPONSES' named entity 'CYTOKINES' named entity 'CENTRAL NERVOUS SYSTEM' named entity 'INDUCED' named entity 'VIRAL INFECTION' named entity 'CYTOTOXIC T CELLS' named entity 'PROCESSES' named entity 'FOLLOWED BY' named entity 'PATHOGENIC' covid:arg/5059b489093b6dd4480b03d0644e89ee739c7785 named entity 'MULTIPLE SCLEROSIS' named entity 'INDUCED' named entity 'AUTOIMMUNE RESPONSES' named entity 'DEMYELINATION' named entity 'IMMUNE-MEDIATED' named entity 'MAY BE A' named entity 'MYELIN' named entity 'INDUCTION' named entity 'HUMAN' named entity 'LEADING' named entity 'ANTIGENS' named entity 'INFLAMMATORY CYTOKINE' named entity 'DIFFERENT' named entity 'INITIAL' named entity 'CNS' named entity 'CYTOKINE LEVELS' named entity 'INFLAMMATORY RESPONSES' named entity 'DISEASE' named entity 'ATTRACTIVE' named entity 'INFECTIOUS' named entity '27S' named entity 'CTL' named entity 'ASSESSMENT' named entity 'CHEMOKINES' named entity 'INITIATION' named entity 'DEMYELINATING DISEASE' named entity 'MECHANISM' named entity 'SPECIFIC' named entity 'SUSTAINING' named entity 'CONSEQUENT' named entity 'VARIOUS' named entity 'ROLE' named entity 'EFFECTS' named entity 'TH1 CELL' named entity 'GLIAL' named entity 'VIRAL PERSISTENCE' named entity 'ANTIGEN PRESENTING CELLS' named entity 'COUPLED' named entity 'COURSE' named entity 'INFLAMMATORY' named entity 'ALTERED' named entity 'ANTIBODY' named entity 'DEMYELINATION' named entity 'demyelinating disease' named entity 'model' named entity 'Although' named entity 'viral infection' named entity 'immune-mediated' named entity 'CNS' named entity 'virus' named entity 'multiple sclerosis'

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