About: It's not TB but what could it be? Abnormalities on chest X-rays taken during the Kenya National Tuberculosis Prevalence Survey

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type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	It's not TB but what could it be? Abnormalities on chest X-rays taken during the Kenya National Tuberculosis Prevalence Survey
Creator	Joekes, Elizabeth Bates, Imelda Rylance, Jamie Zar, Heather Masini, Enos Obasi, Angela Allwood, Brian Morton, Ben Falade, Adegoke Addo-Yobo, Emmanuel Angò, ` Banda, Hastings Binegdie, Amsalu Khan, Jahangir Kiplimo, Richard Kirathe, Dickson Lesosky, Maia Macpherson, Peter Manduku, Veronica Mbatchou, Bertrand Meme, Hellen Mortimer, Kevin Mugi, Beatrice Mungai, Brenda Mutayoba, Beatrice Niessen, Louis Ntinginya, Nyanda Ong, Jane Oronje, Rose Sitienei, Joseph Sony, Asma Squire, Stephen Taegtmeyer, Miriam Tolhurst, Rachel Worodria, William Zulu, Eliya Zurba, Lindsay
Source	MedRxiv
abstract	Background: The prevalence of diseases other than tuberculosis (TB) detected during chest X-ray (CXR) screening is unknown in sub-Saharan Africa. This represents a missed opportunity for identification and treatment of potentially significant disease. Our aim was to quantify and characterise non-TB abnormalities identified by TB-focused CXR screening during the 2016 Kenya National TB prevalence survey. Methods: We reviewed a random sample of 1140 adult ([≥]15 years) CXRs classified as %22abnormal, suggestive of TB%22 or %22abnormal other%22 during field interpretation from the TB Prevalence Survey. Each image was read (blinded to field classification and study radiologist read) by two expert radiologists, with images classified into one of four major anatomical categories and primary radiological diagnosis. A third reader resolved discrepancies. Prevalence and 95% confidence intervals of abnormalities diagnosis were estimated. Findings: Cardiomegaly was the most common non-TB abnormality at 259/1123 (231%, 95% CI 206%-256%), while cardiomegaly with features of cardiac failure occurred in 17/1123 (15 %, 95% CI 0.9%-24%). We also identified chronic pulmonary pathology including suspected chronic obstructive pulmonary disease in 32% (95% CI 23%- 44%) and non-specific patterns in 46% (95% CI 35%- 60%). Prevalence of active-TB and severe post-TB lung changes was 36% (95% CI 26%- 48%) and 14% (95% CI 08%- 2*3%) respectively. Interpretation: Based on radiological diagnosis, we identified a wide variety of non-TB diagnoses during population-based TB screening. TB prevalence surveys and active case finding activities using mass CXR offer an opportunity to integrate disease screening efforts. Funding National Institute for Health Research (IMPALA-grant reference 16/136/35).
has issue date	2020-08-22(xsd:dateTime)
bibo:doi	10.1101/2020.08.19.20177907
has license	medrxiv
sha1sum (hex)	505f3e904611f4fc7a2bb4b8429e18dc54a4777b
schema:url	https://doi.org/10.1101/2020.08.19.20177907
resource representing a document's title	It's not TB but what could it be? Abnormalities on chest X-rays taken during the Kenya National Tuberculosis Prevalence Survey
resource representing a document's body	covid:505f3e904611f4fc7a2bb4b8429e18dc54a4777b#body_text
is schema:about of	named entity 'Kenya' named entity 'Tuberculosis' named entity 'authors' named entity 'Prevalence' named entity 'SBS' named entity 'Prevalence' named entity 'chest X-rays' named entity '95% CI' named entity 'CXR' named entity 'cardiomegaly' named entity 'CRD' named entity 'triaging' named entity 'sub-Saharan African' named entity 'cardiovascular disease' named entity 'major diagnostic categories' named entity 'CXR' named entity 'CXR' named entity 'chronic respiratory disease' named entity 'study protocol' named entity 'cardiomegaly' named entity 'radiologists' named entity 'pathology' named entity 'ischaemic heart diseases' named entity 'bronchiectasis' named entity 'SBS' named entity 'COPD' named entity 'health promotion' named entity 'medRxiv' named entity '95% CI' named entity '95% CI' named entity 'cross-sectional study' named entity 'Google scholar' named entity 'cardiovascular abnormalities' named entity 'medRxiv' named entity 'CXR' named entity 'HIV positive' named entity 'Leprosy' named entity 'follow-up' named entity 'CXR' named entity 'cardiomegaly' named entity 'lung' named entity 'cardiomegaly' named entity '95% CI' named entity 'epidemiology' named entity 'middle-income' named entity 'lung disease' named entity 'spirometry' named entity 'chronic obstructive pulmonary disease' named entity 'medRxiv'

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