About: Generation and evaluation of a recombinant genotype VII Newcastle disease virus expressing VP3 protein of Goose parvovirus as a bivalent vaccine in goslings

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About: Generation and evaluation of a recombinant genotype VII Newcastle disease virus expressing VP3 protein of Goose parvovirus as a bivalent vaccine in goslings Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Generation and evaluation of a recombinant genotype VII Newcastle disease virus expressing VP3 protein of Goose parvovirus as a bivalent vaccine in goslings
Creator	Xia, Xianzhu Yang, Songtao Liu, Xiufan Xiao, Yueqiang Wang, Jianzhong Ding, Zhuang Yin, Renfu Ding, Chan Feng, Na Yu, Shengqing Hu, Shunlin Cong, Yanlong Wang, Chunfeng Wang, Wenxiu
Source	Elsevier; Medline; PMC
abstract	Abstract Newcastle disease virus (NDV) and Goose parvovirus (GPV) are considered to be two of the most important and widespread viruses infecting geese. In this study, we generated a recombinant rmNA-VP3, expressing GPV VP3 using a modified goose-origin NDV NA-1 by changing the multi-basic cleavage site motif RRQKR↓F of the F protein to the dibasic motif GRQGR↓L as that of the avirulent strain LaSota as a vaccine vector. Expression of the VP3 protein in rmNA-VP3 infected cells was detected by immunofluorescence and Western blot assay. The genetic stability was examined by serially passaging 10 times in 10-day-old embryonated SPF chicken eggs. Goslings were inoculated with rmNA-VP3 showed no apparent signs of disease and developed a strong GPV and NDV neutralizing antibodies response. This is the first study demonstrating that recombinant NDV has the potential to serve as bivalent live vaccine against Goose parvovirus and Newcastle disease virus infection in birds.
has issue date	2015-05-04(xsd:dateTime)
bibo:doi	10.1016/j.virusres.2015.04.006
bibo:pmid	25882914
has license	els-covid
sha1sum (hex)	5078f271f0b8d13359084747a8244563005d720a
schema:url	https://doi.org/10.1016/j.virusres.2015.04.006
resource representing a document's title	Generation and evaluation of a recombinant genotype VII Newcastle disease virus expressing VP3 protein of Goose parvovirus as a bivalent vaccine in goslings
has PubMed Central identifier	PMC7114436
has PubMed identifier	25882914
schema:publication	Virus Research
resource representing a document's body	covid:5078f271f0b8d13359084747a8244563005d720a#body_text
is schema:about of	named entity 'changing' named entity 'NDV' named entity 'vaccine' named entity 'stability' named entity 'Newcastle disease virus' named entity 'serially' named entity 'protein' covid:arg/5078f271f0b8d13359084747a8244563005d720a named entity 'The' named entity 'vaccine' named entity 'dibasic' named entity 'potential' named entity 'assay' named entity 'infecting' named entity 'immunofluorescence' named entity 'recombinant' named entity 'NDV' named entity 'NDV' named entity 'VP3' named entity 'vaccine' named entity 'chicken' named entity 'avirulent' named entity 'cleavage site' named entity 'live vaccine' named entity 'genetic stability' named entity 'inoculated' named entity 'embryonated' named entity 'Newcastle disease virus' named entity 'dibasic' named entity 'recombinant' named entity 'Goose parvovirus' named entity 'developed' named entity 'gene' named entity 'live vaccines' named entity 'immunofluorescence' named entity 'antibody' named entity 'goslings' named entity 'vaccine' named entity 'antibody' named entity 'vaccine' named entity 'goslings' named entity 'Serum samples' named entity 'vaccine' named entity 'vaccine' named entity 'goslings' named entity 'viruses' named entity 'vaccine' named entity 'PCR amplified' named entity 'FITC' named entity 'lysates' named entity 'antibody' named entity 'genotype' named entity 'NDV' named entity 'reverse genetics' named entity 'virulent strain' named entity 'NDV' named entity 'syncytia' named entity 'ICPI' named entity 'poultry' named entity 'IgG' named entity 'panzootic' named entity 'genome' named entity 'pathogenicity' named entity 'NDV' named entity 'antigenicity' named entity 'cDNA' named entity 'fibroblasts' named entity 'protein cleavage'

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