About: Pandemic Influenza: A Potential Role for Statins in Treatment and Prophylaxis

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An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
title	Pandemic Influenza: A Potential Role for Statins in Treatment and Prophylaxis
Creator	Cid, Influenza, • Statins, Pandemic
source	Medline; PMC
abstract	The next influenza pandemic may be imminent. Because antiviral agents and vaccines will be unavailable to people in most countries, we need to determine whether other agents could offer clinical benefits. Influenza is associated with an increase in acute cardiovascular diseases, and influenza viruses induce proinflammatory cytokines. Statins are cardioprotective and have anti-inflammatory and immunomodulatory effects, and they thus might benefit patients with influenza. This hypothesis should be evaluated by using administrative databases to search for reduced rates of hospitalization and death due to influenza-related conditions among people taking statins. These studies should be followed by laboratory studies of statins in animal and cell-based models of influenza virus infection and, later, by clinical trials. Positive results from such studies would provide physicians in all countries with something to offer patients for treatment and prophylaxis of pandemic influenza. Generic statins will be widely distributed and inexpensive. They might be the only agents that could alter the course of a global pandemic.
has issue date	2006-07-15(xsd:dateTime)
bibo:doi	10.1086/505116
bibo:pmid	16779747
has license	no-cc
sha1sum (hex)	509190b03505878ded0f0d63a57e4900551b4ad7
schema:url	https://doi.org/10.1086/505116
resource representing a document's title	Pandemic Influenza: A Potential Role for Statins in Treatment and Prophylaxis
has PubMed Central identifier	PMC7107836
has PubMed identifier	16779747
schema:publication	Clin Infect Dis
resource representing a document's body	covid:509190b03505878ded0f0d63a57e4900551b4ad7#body_text
is schema:about of	named entity 'POTENTIAL' named entity 'PROPHYLAXIS' named entity 'They' named entity 'patients' named entity 'patients' named entity 'Treatment' named entity 'Prophylaxis' named entity 'TREATMENT' covid:arg/509190b03505878ded0f0d63a57e4900551b4ad7 named entity 'ROLE' named entity 'PEOPLE' named entity 'ANIMAL' named entity 'VACCINES' named entity 'HOSPITALIZATION' named entity 'STATINS' named entity 'VIRUS INFECTION' named entity 'DATABASES' named entity 'HYPOTHESIS' named entity 'CELL' named entity 'INFLUENZA' named entity 'CLINICAL TRIALS' named entity 'SOMETHING' named entity 'EFFECTS' named entity 'USING' named entity 'UNAVAILABLE' named entity 'CONDITIONS' named entity 'SEARCH' named entity 'RATES' named entity 'PROVIDE' named entity 'POSITIVE' named entity 'PROINFLAMMATORY CYTOKINES' named entity 'TREATMENT' named entity 'IMMINENT' named entity 'INFLUENZA' named entity 'PANDEMIC' named entity 'CLINICAL BENEFITS' named entity 'DUE TO' named entity 'PANDEMIC' named entity 'LABORATORY STUDIES' named entity 'DEATH' named entity 'BENEFIT' named entity 'PROPHYLAXIS OF' named entity 'ALTER' named entity 'HAVE' named entity 'TAKING' named entity 'STATINS' named entity 'INCREASE' named entity 'ASSOCIATED WITH' named entity 'MODELS' named entity 'BASED' named entity 'NEED' named entity 'PATIENTS' named entity 'INDUCE' named entity 'LATER' named entity 'REDUCED' named entity 'ACUTE' named entity 'ANTI-INFLAMMATORY' named entity 'MAY BE' named entity 'INFLUENZA PANDEMIC' named entity 'CARDIOVASCULAR DISEASES' named entity 'DISTRIBUTED' named entity 'ADMINISTRATIVE' named entity 'ANTIVIRAL AGENTS' named entity 'IMMUNOMODULATORY' named entity 'INFLUENZA VIRUS' named entity 'RESULTS' named entity 'DETERMINE' named entity 'STUDIES' named entity 'PHYSICIANS' named entity 'OFFER' named entity 'FOLLOWED BY' named entity 'GENERIC' named entity 'THESE' named entity 'INFLUENZA VIRUSES' named entity 'CARDIOPROTECTIVE' named entity 'COUNTRIES' named entity 'GLOBAL' named entity 'COURSE' named entity 'EVALUATED'

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