About: Local RAS

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type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Local RAS
Source	Medline; PMC
abstract	The concept of a circulating RAS is well established and known to play an endocrine role in the regulation of fluid homeostasis (see Section 4.1, Chapter 4). However, it is more appropriate to view the RAS in the contemporary notion as an “angiotensin-generating system”, which consists of angiotensinogen, angiotensin-generating enzymes, and angiotensins, as well as their receptors. Some RASs can be termed as “complete”, having renin and ACE involved in the biosynthesis of angiotensin II peptide, i.e. in a renin and/or ACE-dependent manner which is exemplified in the circulating RAS. On the other hand, some RAS can be termed as “partial”, having alternate enzymes to renin and ACE, such as chymase and ACE2 (see Section 4.3, Chapter 4) available for the generation of angiotensin II and other bioactive angiotensin peptides in the biosynthetic cascade, i.e. in a renin and/or ACE-independent manner. Complete vs. partial RASs can be exemplified in the so-called intrinsic angiotensin-generating system or local RAS; for example, a local and functional RAS with renin and ACE-dependent but a renin-independent pathway have been indentified in the pancreas and carotid body, respectively. In the past two decades, local RASs have gained increasing recognition especially with regards to their clinical importance. Distinct from the circulating RAS, these functional local RASs exist in such diverse tissues and organs as the pancreas, liver, intestine, heart, kidney, vasculature, carotid body, and adipose, as well as the nervous, reproductive, and digestive systems. Taken into previous findings from our laboratory and others together, Table 5.1 is a summary of some recently identified local RASs in various levels of tissues and organs.
has issue date	2010-05-05(xsd:dateTime)
bibo:doi	10.1007/978-90-481-9060-7_5
bibo:pmid	20700838
has license	no-cc
sha1sum (hex)	50b281ac00f308e55bc92cf330c098ccd8e610a1
schema:url	https://doi.org/10.1007/978-90-481-9060-7_5
resource representing a document's title	Local RAS
has PubMed Central identifier	PMC7120160
has PubMed identifier	20700838
schema:publication	The Renin-Angiotensin System: Current Research Progress in The Pancreas
resource representing a document's body	covid:50b281ac00f308e55bc92cf330c098ccd8e610a1#body_text
is schema:about of	named entity 'DEFINITION' named entity 'RAS' named entity 'LOCAL' named entity 'jejunum' named entity 'blood-brain barrier' named entity 'enterocyte' named entity 'Glucose' named entity 'leucine' named entity 'endothelial cells' named entity 'Fung' named entity 'centrally-mediated' named entity 'immunofluorescence' named entity 'glucose' named entity 'diabetes mellitus' named entity 'glucose' named entity 'GLUT2' named entity 'hormonal' named entity 'CHF' named entity 'phagocytizing' named entity 'Kupffer cells' named entity 'RAS' named entity 'RAS' named entity 'receptor agonists' named entity 'liver fibrosis' named entity 'liver' named entity 'clinical setting' named entity 'apical membrane' named entity 'GLUT4' named entity 'carotid body' named entity 'liver failure' named entity 'postnatal' named entity 'enterocyte' named entity 'methyl' named entity 'NASH' named entity 'non-peptide' named entity 'bacteria' named entity 'Caco-2' named entity 'metabolism of carbohydrates' named entity 'enterocyte' named entity 'angiotensin II' named entity 'diabetic' named entity 'RAS' named entity 'Hypoxia' named entity 'animal model' named entity 'RAS' named entity 'immunocytochemistry' named entity 'enterocyte' named entity 'hepatocytes' named entity 'immunostaining' named entity 'transcription' named entity 'leptin' named entity 'cardiovascular diseases' named entity 'glucose' named entity 'glucose transport' named entity 'stellate cells' named entity 'Insulin resistance' named entity 'hypoxic ventilatory response' named entity 'cell line' named entity 'T2DM' named entity 'Kupffer cells' named entity 'stellate cells' named entity 'NAFLD' named entity 'assay' named entity 'cardiac output' named entity 'protein expression' named entity 'losartan' named entity 'RAS' named entity 'glucose' named entity 'angiotensinogen' named entity 'stellate cells' named entity 'wild type' named entity 'red blood cell' named entity 'streptozotocin' named entity 'RAS' named entity 'vascularised' named entity 'translocation' named entity 'vitamin' named entity 'renin' named entity 'TGF-β' named entity 'T2DM' named entity 'enterocyte' named entity 'ACE2'

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