About: Characteristics of the complement system gene expression deficiency in patients with symptomatic pulmonary embolism

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About: Characteristics of the complement system gene expression deficiency in patients with symptomatic pulmonary embolism Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

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type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Characteristics of the complement system gene expression deficiency in patients with symptomatic pulmonary embolism
Creator	Yang, Fan Duan, Qianglin Wang, Lemin Gong, Zhu Lv, Wei Song, Haoming Song, Yanli
Source	Elsevier; Medline; PMC
abstract	Abstract Introduction Pulmonary embolism (PE) is a disease with a high mortality and morbidity rate, and the pathogenesis of PE remains still unclear. We aimed to investigate the gene expression differences of the complement system in peripheral blood mononuclear cells (PBMCs) from patients with symptomatic PE and controls. Methods Twenty cases of PE patients and twenty sex and age matched controls were recruited into the study. Human cDNA microarray analysis was used to detect the gene expression difference of the complement system between the two groups. Results 1). Expression of twenty-one genes encoding complement components was detected. In PE patients, expression of the genes encoding C1qα, C1qβ, C4b, C5 and Factor P was significantly greater (P<0.05) than controls, while C6, C7, C9, mannose-binding lectin (MBL) and mannan-binding lectin serine peptidase 1 (MASP1) mRNAs were lower (P<0.05) than controls. 2). Expression of seven genes encoding complement receptors was examined. In PE patients, CR1, integrin αM, integrin αX and C5aR mRNAs were significantly up-regulated (P<0.01) compared with controls. 3). Seven genes encoding complement regulators were examined. The mRNA expression of CD59 and CD55 was significantly up-regulated (P<0.05), whereas Factor I mRNA was significantly down-regulated (P<0.05) in PE patients than controls. Conclusions In PE patients, the mRNA expressions of complement components, receptors and regulators were unbalanced, suggesting dysfunction and/or deficiency of the complement system, which leads to decreased function of MAC-induced cell lysis in PE patients finally.
has issue date	2013-07-31(xsd:dateTime)
bibo:doi	10.1016/j.thromres.2013.04.027
bibo:pmid	23726092
has license	els-covid
sha1sum (hex)	50c1c7e04ad2bc4d6bea24917e2d82a0f8950e30
schema:url	https://doi.org/10.1016/j.thromres.2013.04.027
resource representing a document's title	Characteristics of the complement system gene expression deficiency in patients with symptomatic pulmonary embolism
has PubMed Central identifier	PMC7112067
has PubMed identifier	23726092
schema:publication	Thrombosis Research
resource representing a document's body	covid:50c1c7e04ad2bc4d6bea24917e2d82a0f8950e30#body_text
is schema:about of	named entity 'groups' named entity 'up-regulated' named entity 'PBMCs' named entity 'patients' named entity 'REMAINS' named entity 'EXPRESSION' named entity 'USED' named entity '0.01' named entity 'DISEASE' named entity 'CDNA MICROARRAY ANALYSIS' named entity 'CD59' named entity 'UNBALANCED' named entity 'COMPLEMENT REGULATORS' named entity 'DEFICIENCY OF' named entity 'STUDY' named entity 'COMPLEMENT COMPONENTS' named entity 'DIFFERENCE' named entity 'UNCLEAR' named entity 'DETECTED' named entity 'MATCHED' named entity 'UP-REGULATED' covid:arg/50c1c7e04ad2bc4d6bea24917e2d82a0f8950e30 named entity 'INTEGRIN' named entity 'TWENTY-ONE' named entity 'DECREASED FUNCTION' named entity 'TO DETECT' named entity 'INTRODUCTION' named entity '28P' named entity 'TWENTY' named entity 'ENCODING' named entity 'REGULAR' named entity 'ARTICLE' named entity 'C5AR' named entity 'PATHOGENESIS' named entity 'SERINE PEPTIDASE' named entity 'FACTOR I' named entity 'GENE EXPRESSION' named entity 'C1Q' named entity 'EXAMINED' named entity 'SEVEN' named entity 'GROUPS' named entity 'HIGH' named entity 'COMPLEMENT RECEPTORS' named entity 'COMPLEMENT SYSTEM' named entity 'CR1' named entity 'INDUCED' named entity 'CONCLUSIONS' named entity 'MANNOSE-BINDING LECTIN' named entity 'PERIPHERAL BLOOD MONONUCLEAR CELLS' named entity 'MRNA' named entity 'DYSFUNCTION' named entity 'AGE' named entity 'SYMPTOMATIC' named entity 'LOWER' named entity 'LEADS' named entity 'CELL LYSIS' named entity 'DOWN-REGULATED' named entity 'CASES' named entity 'MRNA EXPRESSION' named entity 'MORTALITY' named entity '0.05' named entity 'MORBIDITY RATE' named entity 'GREATER' named entity 'PULMONARY EMBOLISM' named entity 'PATIENTS' named entity 'GENES' named entity 'C4B' named entity 'HUMAN' named entity 'TO INVESTIGATE' named entity 'RECEPTORS' named entity 'FACTOR P' named entity 'COMPARED' named entity 'MRNAS' named entity 'CD55' named entity 'SEX'

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