About: Prediction of Potential Epitopes for Peptide Vaccine Formulation Against Teschovirus A Using Immunoinformatics

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An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Prediction of Potential Epitopes for Peptide Vaccine Formulation Against Teschovirus A Using Immunoinformatics
Creator	Barman, Antara Chakraborty, Supriyo Deb, ·
Source	PMC
abstract	Teschovirus A belongs to the family Picornaviridae and is a causal agent of the disease Teschovirus encephalomyelitis and other infections that remain asymptomatic. The present study was performed to design epitope-based peptide vaccine against Teschovirus A by identifying the potential T cell and B-cell epitopes from capsid proteins (VP1, VP3 and VP2) of the virus using reverse vaccinology and immunoinformatics approaches. In the current study, hexapeptide T-cell and octapeptide B-cell epitopes were analyzed for immunogenicity, antigenicity and hydrophilicity scores of each epitope. Each potential epitope was further characterized using ExPASy-ProtParam and Antimicrobial Peptide Database (APD3) tools for determining various physical and chemical parameters of the epitope. One linear hexapeptide T-cell epitope, i.e., RPVNDE (epitope position 77–82) and one linear octapeptide B-cell epitope, i.e., AYSRSHPQ (236–243) were identified from the viral capsid protein as they possess the capability to raise effective immunogenic reaction in the host organism against the virus. Pharmaceutical industries could harness the results of this investigation to develop epitope-based peptide vaccines by loading the identified epitopes in combination with targeting signal peptides of T-cells and B-cells and then inserting the combination into virus like particle (vlp) or constructing subunit vaccines for further trial.
has issue date	2019-08-16(xsd:dateTime)
bibo:doi	10.1007/s10989-019-09916-1
bibo:pmid	32435170
has license	no-cc
sha1sum (hex)	50e9c839f0f5e1865eccdfccdc8a3d651c5c46f6
schema:url	https://doi.org/10.1007/s10989-019-09916-1
resource representing a document's title	Prediction of Potential Epitopes for Peptide Vaccine Formulation Against Teschovirus A Using Immunoinformatics
has PubMed Central identifier	PMC7223446
has PubMed identifier	32435170
schema:publication	Int J Pept Res Ther
resource representing a document's body	covid:50e9c839f0f5e1865eccdfccdc8a3d651c5c46f6#body_text
is schema:about of	named entity 'IMMUNOGENICITY' named entity 'PHARMACEUTICAL INDUSTRIES' named entity 'INFECTIONS' named entity 'SUBUNIT VACCINES' named entity 'Picornaviridae' named entity 'hydrophilicity' named entity 'Teschovirus' named entity 'epitope' named entity 'VP2' named entity 'peptide vaccine' named entity 'Pharmaceutical industries' named entity 'epitope' named entity 'Antimicrobial Peptide' named entity 'octapeptide' named entity 'epitopes' named entity 'epitope' named entity 'epitope' named entity 'Peptide Vaccine' named entity 'epitopes' named entity 'epitopes' named entity 'hexapeptide' named entity 'epitope' named entity 'epitope' named entity 'Teschovirus' named entity 'Teschovirus' named entity 'VP2' named entity 'wild boars' named entity 'signs of infection' named entity 'Romania' named entity 'amino acids' named entity 'hydrophilicity' named entity 'viruses' named entity 'Africa' named entity 'Porcine Teschovirus' named entity 'Infection' named entity 'antigenicity' named entity 'empirical method' named entity 'C-terminal end' named entity '7.1' named entity 'T-cell' named entity 'virus' named entity 'epitopes' named entity 'neurological disease' named entity 'epitopes' named entity 'protein' named entity 'peptide vaccine' named entity 'hydrophilicity' named entity 'epitope' named entity 'amino acids' named entity 'epitope' named entity 'protein' named entity 'polyprotein' named entity 'protein' named entity 'epitopes' named entity 'PTV' named entity 'amino acids' named entity 'epitope' named entity 'protein' named entity 'protein' named entity 'VP1' named entity 'epitope' named entity 'epitope' named entity 'peptide vaccines' named entity 'round in shape' named entity 'epitopes' named entity 'T-cell' named entity 'encephalomyelitis' named entity 'immunogenicity' named entity 'immunogenicity' named entity 'aliphatic' named entity 'Teschovirus' named entity 'peptide vaccines' named entity 'protein' named entity 'genomics' named entity 'epitopes' named entity 'epitopes' named entity 'B-cell' named entity 'vaccine' named entity 'hydrophilicity'

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