About: Punica granatum L. Leaf Extract Attenuates Lung Inflammation in Mice with Acute Lung Injury

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An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Punica granatum L. Leaf Extract Attenuates Lung Inflammation in Mice with Acute Lung Injury
Creator	Monteiro-Neto, Valério Brito, Natilene Fernandes, Elizabeth Gonçalves, Jaciara Lee, Ann Silva, Lanna Batista, Aranha Campbell, Cortez De Sá, Joicy Costa, Matheus Cristina, Marisa Dourado, Alves Gonçalves Lima-Neto, Lidio Joaquim, Aruanã Martins De Sousa, Eduardo Pinheiro, Rodrigues Regina, Cinara Vieira Monteiro, Aragão Wilenna, Ádylla Wiziack Zago, Patrícia
Source	PMC
abstract	The hydroalcoholic extract of Punica granatum (pomegranate) leaves was previously demonstrated to be anti-inflammatory in a rat model of lipopolysaccharide- (LPS-) induced acute peritonitis. Here, we investigated the anti-inflammatory effects of the ethyl acetate fraction obtained from the pomegranate leaf hydroalcoholic extract (EAFPg) on the LPS-induced acute lung injury (ALI) mouse model. Male Swiss mice received either EAFPg at different doses or dexamethasone (per os) prior to LPS intranasal instillation. Vehicle-treated mice were used as controls. Animals were culled at 4 h after LPS challenge, and the bronchoalveolar lavage fluid (BALF) and lung samples were collected for analysis. EAFPg and kaempferol effects on NO and cytokine production by LPS-stimulated RAW 264.7 macrophages were also investigated. Pretreatment with EAFPg (100–300 mg/kg) markedly reduced cell accumulation (specially neutrophils) and collagen deposition in the lungs of ALI mice. The same animals presented with reduced lung and BALF TNF-α and IL-1β expression in comparison with vehicle controls (p < 0.05). Additionally, incubation with either EAFPg or kaempferol (100 μg/ml) reduced NO production and cytokine gene expression in cultured LPS-treated RAW 264.7 macrophages. Overall, these results demonstrate that the prophylactic treatment with EAFPg attenuates acute lung inflammation. We suggest this fraction may be useful in treating ALI.
has issue date	2018-02-20(xsd:dateTime)
bibo:doi	10.1155/2018/6879183
bibo:pmid	29675437
has license	cc-by
sha1sum (hex)	512ad31f56a7be38e686f3864431191b0b9f659e
schema:url	https://doi.org/10.1155/2018/6879183
resource representing a document's title	Punica granatum L. Leaf Extract Attenuates Lung Inflammation in Mice with Acute Lung Injury
has PubMed Central identifier	PMC5838491
has PubMed identifier	29675437
schema:publication	J Immunol Res
resource representing a document's body	covid:512ad31f56a7be38e686f3864431191b0b9f659e#body_text
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