About: Identification and Characterization of a Novel Alpaca Respiratory Coronavirus Most Closely Related to the Human Coronavirus 229E

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About: Identification and Characterization of a Novel Alpaca Respiratory Coronavirus Most Closely Related to the Human Coronavirus 229E Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
title	Identification and Characterization of a Novel Alpaca Respiratory Coronavirus Most Closely Related to the Human Coronavirus 229E
Creator	Callison, Scott Crossley, Beate Hietala, Sharon Mock, Richard
source	Medline; PMC
abstract	In 2007, a novel coronavirus associated with an acute respiratory disease in alpacas (Alpaca Coronavirus, ACoV) was isolated. Full-length genomic sequencing of the ACoV demonstrated the genome to be consistent with other Alphacoronaviruses. A putative additional open-reading frame was identified between the nucleocapsid gene and 3'UTR. The ACoV was genetically most similar to the common human coronavirus (HCoV) 229E with 92.2% nucleotide identity over the entire genome. A comparison of spike gene sequences from ACoV and from HCoV-229E isolates recovered over a span of five decades showed the ACoV to be most similar to viruses isolated in the 1960’s to early 1980’s. The true origin of the ACoV is unknown, however a common ancestor between the ACoV and HCoV-229E appears to have existed prior to the 1960’s, suggesting virus transmission, either as a zoonosis or anthroponosis, has occurred between alpacas and humans.
has issue date	2012-12-12(xsd:dateTime)
bibo:doi	10.3390/v4123689
bibo:pmid	23235471
has license	cc-by
sha1sum (hex)	5136621ef7ae0c8d8b2dd396e432bedceb3f0331
schema:url	https://doi.org/10.3390/v4123689
resource representing a document's title	Identification and Characterization of a Novel Alpaca Respiratory Coronavirus Most Closely Related to the Human Coronavirus 229E
has PubMed Central identifier	PMC3528286
has PubMed identifier	23235471
schema:publication	Viruses
resource representing a document's body	covid:5136621ef7ae0c8d8b2dd396e432bedceb3f0331#body_text
is schema:about of	named entity '3'UTR' named entity 'existed' named entity 'Coronavirus' named entity 'genetically' named entity 'Related' covid:arg/5136621ef7ae0c8d8b2dd396e432bedceb3f0331 named entity 'READING FRAME' named entity 'A COMMON' named entity 'COMPARISON' named entity 'ISOLATES' named entity 'VIRUS' named entity 'NUCLEOCAPSID' named entity 'RECOVERED' named entity 'TRANSMISSION' named entity 'LENGTH' named entity 'ENTIRE' named entity 'HUMAN CORONAVIRUS' named entity 'HAVE' named entity 'ASSOCIATED WITH' named entity 'GENOME' named entity 'SPAN' named entity 'HUMAN CORONAVIRUS 229E' named entity '1960' named entity 'ACOV' named entity 'CORONAVIRUS' named entity 'IDENTIFICATION' named entity 'RELATED' named entity 'CHARACTERIZATION' named entity 'HUMANS' named entity 'COMMON' named entity 'TRUE' named entity 'ADDITIONAL' named entity 'SEQUENCES' named entity 'EITHER' named entity 'HCOV-229E' named entity 'ANCESTOR' named entity 'OCCURRED' named entity 'GENE' named entity 'DEMONSTRATED' named entity 'GENOMIC SEQUENCING' named entity 'SPIKE' named entity 'UNKNOWN' named entity 'PRIOR TO' named entity 'ZOONOSIS' named entity 'EARLY' named entity 'OPEN' named entity 'ORIGIN' named entity 'IDENTIFIED' named entity 'NOVEL CORONAVIRUS' named entity '229E' named entity 'SIMILAR' named entity 'ALPACAS' named entity 'ISOLATED' named entity 'IDENTITY' named entity 'ALPACA RESPIRATORY CORONAVIRUS' named entity 'NOVEL' named entity '27S' named entity 'CONSISTENT WITH' named entity 'ACUTE RESPIRATORY DISEASE' named entity 'NUCLEOTIDE' named entity 'VIRUSES' named entity 'spike' named entity 'alpacas' named entity 'isolated' named entity '2007' named entity '1980' named entity 'genomic sequencing' named entity 'viruses' named entity 'polyprotein' named entity 'genome' named entity 'virus' named entity 'alpaca' named entity 'ferret' named entity 'Betacoronavirus' named entity 'Aminopeptidase' named entity 'enzyme' named entity 'viral proteins' named entity 'phylogenetically'

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