About: Apolipoprotein D in Lipid Metabolism and Its Functional Implication in Atherosclerosis and Aging

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An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

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type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
title	Apolipoprotein D in Lipid Metabolism and Its Functional Implication in Atherosclerosis and Aging
source	Medline; PMC
abstract	Dyslipidemia is characterized by increased triglyceride and low-density lipoprotein (LDL) levels, and decreased high-density lipoprotein (HDL) levels. Such an atherogenic lipid profile often predisposes an at risk individual to coronary artery disease with incompletely understood mechanisms. Apolipoprotein D (apoD) is an atypical apolipoprotein. Unlike canonical apolipoproteins that are produced mainly in liver and intestine, apoD is expressed widely in mammalian tissues. ApoD does not share significant degrees of homology in amino acid sequence with other apolipoproteins. Instead, apoD is structurally similar to lipocalins, a diverse family of lipid-binding proteins that are responsible for transporting lipids and other small hydrophobic molecules for metabolism. Plasma ApoD is present mainly in HDL and to a lesser extent in low density lipoproteins (LDL) and very low-density lipoproteins (VLDL). Genetic variants of apoD are associated with abnormal lipid metabolism and increased risk of developing metabolic syndrome. Increased apoD deposition is detectable in atherosclerotic lesions of humans with established cardiovascular disease as well as mice with premature atherosclerosis. Moreover, apoD is associated with anti-oxidation and anti-stress activities, contributing to lifespan expansion in fruit flies. Elderly subjects and patients with Alzheimer exhibit markedly elevated apoD production in the brain. Thus, apoD is emerged as a significant player in lipid metabolism and aging. Here we focus our review on recent advances toward our understanding of apoD in lipid metabolism and address whether apoD dysregulation contributes to the pathogenesis of dyslipidemia and atherosclerosis. We will also discuss the functional implication of apoD in aging.
has issue date	2008-12-12(xsd:dateTime)
bibo:pmid	19946382
has license	cc-by
sha1sum (hex)	513a25eb7a96ba7f7ae433498caf4791eb19e97c
resource representing a document's title	Apolipoprotein D in Lipid Metabolism and Its Functional Implication in Atherosclerosis and Aging
has PubMed Central identifier	PMC2784685
has PubMed identifier	19946382
schema:publication	Aging (Albany NY)
resource representing a document's body	covid:513a25eb7a96ba7f7ae433498caf4791eb19e97c#body_text
is schema:about of	named entity 'ATHEROSCLEROSIS' named entity 'leptin receptor' named entity 'metabolism' named entity 'apoD' named entity 'apoD' named entity 'Tangier disease' named entity 'amino acids' named entity 'glycosylated' named entity 'Do Carmo' named entity 'apoD' named entity 'hypothalamus' named entity 'Thr' named entity 'fatty streaks' named entity 'apoA-II' named entity 'ApoD' named entity 'leptin receptor' named entity 'breast cancer' named entity 'apolipoproteins' named entity 'apoD' named entity 'ethidium bromide' named entity 'cross-link' named entity 'ABCA1' named entity 'catabolized' named entity 'ApoD' named entity 'apoD' named entity 'hydrophobic' named entity 'IgG' named entity 'food intake' named entity 'acute encephalitis' named entity 'apoD' named entity 'oxidative stress' named entity 'ApoA-I' named entity 'cholesterol' named entity 'immunohistochemistry' named entity 'mice' named entity 'leptin receptor' named entity 'apoD' named entity 'ClustalW' named entity 'plasma' named entity 'apoD' named entity 'apoA-II' named entity 'gene' named entity 'LCAT' named entity 'arachidonic acid' named entity 'apoD' named entity 'cholesterol' named entity 'fruit flies' named entity 'apoD' named entity 'mutants' named entity 'pathogenesis' named entity 'HDL' named entity 'leptin receptor' named entity 'pancreas' named entity 'apoD' named entity 'pathogenesis' named entity 'apoA-II' named entity 'agarose gel' named entity 'apoD' named entity 'Cy3' named entity 'hydrophobic molecules' named entity 'amyloid plaques' named entity 'Vijayaraghavan' named entity 'muscle biopsies' named entity 'polymorphism' named entity 'lysolecithin' named entity 'HDL' named entity 'ApoE' named entity 'HDL' named entity 'atherosclerotic plaques' named entity 'C57BL/6J' named entity 'hepatocellular carcinoma' named entity 'Valencia, CA' named entity 'leptin receptor' named entity 'atherosclerosis' named entity 'hypothalamus' named entity 'triglyceride' named entity 'Mass Spectrometric' named entity 'stroke' named entity 'UV light' named entity 'cystic disease' named entity 'apoD' named entity 'lipocalin' named entity 'atherosclerosis' named entity 'cholesterol'

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