About: Interleukin 16 contributes to gammaherpesvirus pathogenesis by inhibiting viral reactivation

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An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
title	Interleukin 16 contributes to gammaherpesvirus pathogenesis by inhibiting viral reactivation
Creator	Li, Jie Liu, Shuai Qian, Zhikang Jia, Ran Speck, Samuel Wang, Liu Gao, Ying Jiang, Congwei Kuang, Linlin Lei, Zhangmengxue Liangid, Xiaozhen Liu, Mu Liu, Zhongshun Zhouid, Dongming
topic	covid:51421e94622c391902ad609d9bfaa85f533e20fe#this
source	Medline; PMC
abstract	Gammaherpesviruses have evolved various strategies to take advantage of host cellular factors or signaling pathways to establish a lifelong latent infection. Like the human gammaherpesvirus Epstein-Barr virus, murine gammaherpesvirus 68 (MHV68) establishes and maintains latency in the memory B cells during infection of laboratory mice. We have previously shown that MHV68 can immortalize fetal liver-derived B cells that induce lymphomas when injected into immunodeficient mice. Here we identify interleukin 16 (IL16) as a most abundantly expressed cytokine in MHV68-immortalized B cells and show that MHV68 infection elevates IL16 expression. IL16 is not important for MHV68 lytic infection but plays a critical role in MHV68 reactivation from latency. IL16 deficiency increases MHV68 lytic gene expression in MHV68-immortalized B cells and enhances reactivation from splenic latency. Correlatively, IL16 deficiency increases the frequency of MHV68-infected plasma cells that can be attributed to enhanced MHV68 reactivation. Furthermore, similar to TPA-mediated lytic replication of Kaposi's sarcoma-associated herpesvirus, IL16 deficiency markedly induces Tyr705 STAT3 de-phosphorylation and elevates p21 expression, which can be counteracted by the tyrosine phosphatase inhibitor orthovanadate. Importantly, orthovanadate strongly blocks MHV68 lytic gene expression mediated by IL16 deficiency. These data demonstrate that virus-induced IL16 does not directly participate in MHV68 lytic replication, but rather inhibits virus reactivation to facilitate latent infection, in part through the STAT3-p21 axis.
has issue date	2020-07-31(xsd:dateTime)
bibo:doi	10.1371/journal.ppat.1008701
bibo:pmid	32735617
has license	cc-by
sha1sum (hex)	51421e94622c391902ad609d9bfaa85f533e20fe
schema:url	https://doi.org/10.1371/journal.ppat.1008701
resource representing a document's title	Interleukin 16 contributes to gammaherpesvirus pathogenesis by inhibiting viral reactivation
has PubMed Central identifier	PMC7423151
has PubMed identifier	32735617
schema:publication	PLoS Pathog
resource representing a document's body	covid:51421e94622c391902ad609d9bfaa85f533e20fe#body_text
is http://vocab.deri.ie/void#inDataset of	proxy:http/ns.inria.fr/covid19/51421e94622c391902ad609d9bfaa85f533e20fe
is schema:about of	named entity 'B cells' named entity 'lytic' named entity 'fetal' named entity 'critical role' named entity 'maintains' named entity 'elevates' named entity 'data' named entity 'immortalized' named entity 'inhibiting' named entity 'Interleukin 16' named entity 'interleukin' named entity 'gene' named entity 'plasma cells' named entity 'murine' named entity 'blocks' named entity 'frequency' named entity 'infection' named entity 'host' named entity 'STAT3' named entity 'mice' named entity 'viral' named entity 'IL16' named entity 'latent infection' named entity 'virus' named entity 'Gammaherpesviruses' named entity 'IL16' named entity 'virus' named entity 'interleukin 16' named entity 'p21' named entity 'latent infection' named entity 'lymphomas' named entity 'cytokine' named entity 'gene expression' named entity 'Epstein-Barr virus' named entity 'memory B cells' named entity 'injected' named entity 'Addgene' named entity 'amino acid' named entity 'JAK-STAT' named entity 'infection' named entity 'intranasally' named entity 'APC' named entity 'IL16' named entity 'IL16' named entity 'transfected' named entity 'CD3' named entity 'HIV-1' named entity 'endogenous' named entity 'cloned' named entity 'expression profiling' named entity 'IL16' named entity 'IL16' named entity 'supernatant' named entity 'lentiviral' named entity 'gene expression' named entity 'Institut Pasteur' named entity 'IL16' named entity 'IL16' named entity 'IL16' named entity 'lytic' named entity 'STAT3' named entity 'primers' named entity 'IL16' named entity 'gene' named entity 'infection' named entity 'IL16'

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