About: Epidemiologic, clinical, and virologic characteristics of human rhinovirus infection among otherwise healthy children and adults

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About: Epidemiologic, clinical, and virologic characteristics of human rhinovirus infection among otherwise healthy children and adults Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

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type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Epidemiologic, clinical, and virologic characteristics of human rhinovirus infection among otherwise healthy children and adults
Creator	Mor, Deepika Ridoré, Michelande Chen, Wei-Ju Garcia, Josefina Ottolini, Martin Schofield, Christina Fairchok, Mary Burgess, Timothy Arnold, John Blair, Patrick Danaher, Patrick Halsey, Eric Millar, Eugene Mcdonough, Erin
Source	Elsevier; Medline; PMC
abstract	BACKGROUND: Human rhinovirus (HRV) is a major cause of influenza-like illness (ILI) in adults and children. Differences in disease severity by HRV species have been described among hospitalized patients with underlying illness. Less is known about the clinical and virologic characteristics of HRV infection among otherwise healthy populations, particularly adults. OBJECTIVES: To characterize molecular epidemiology of HRV and association between HRV species and clinical presentation and viral shedding. STUDY DESIGN: Observational, prospective, facility-based study of ILI was conducted from February 2010 to April 2012. Collection of nasopharyngeal specimens, patient symptoms, and clinical information occurred on days 0, 3, 7, and 28. Patients recorded symptom severity daily for the first 7 days of illness in a symptom diary. HRV was identified by RT-PCR and genotyped for species determination. Cases who were co-infected with other viral respiratory pathogens were excluded from the analysis. We evaluated the associations between HRV species, clinical severity, and patterns of viral shedding. RESULTS: Eighty-four HRV cases were identified and their isolates genotyped. Of these, 62 (74%) were >18y. Fifty-four were HRV-A, 11 HRV-B, and 19 HRV-C. HRV-C infection was more common among children than adults (59% vs. 10%, P<0.001). Among adults, HRV-A was associated with higher severity of upper respiratory symptoms compared to HRV-B (P=0.02), but no such association was found in children. In addition, adults shed HRV-A significantly longer than HRV-C (Ptrend=0.01). CONCLUSIONS: Among otherwise healthy adults with HRV infection, we observed species-specific differences in respiratory symptom severity and duration of viral shedding.
has issue date	2015-03-01(xsd:dateTime)
bibo:doi	10.1016/j.jcv.2015.01.007
bibo:pmid	25728083
has license	green-oa
sha1sum (hex)	51667c85b8b8170c950a1b561b3f2245c3cdce25
schema:url	https://doi.org/10.1016/j.jcv.2015.01.007
resource representing a document's title	Epidemiologic, clinical, and virologic characteristics of human rhinovirus infection among otherwise healthy children and adults
has PubMed Central identifier	PMC4347877
has PubMed identifier	25728083
schema:publication	Journal of Clinical Virology
resource representing a document's body	covid:51667c85b8b8170c950a1b561b3f2245c3cdce25#body_text
is schema:about of	named entity 'illness' named entity 'KNOWN' named entity 'VIROLOGIC' named entity 'A MAJOR' named entity 'ILLNESS' named entity 'IS A' named entity 'BACKGROUND' named entity 'VIROLOGIC' named entity 'ADULTS' named entity 'CLINICAL' named entity 'RHINOVIRUS INFECTION' named entity 'EPIDEMIOLOGIC' named entity 'HEALTHY' named entity 'HUMAN RHINOVIRUS' named entity 'UNDERLYING' named entity 'ADULTS' named entity 'ABOUT' named entity 'SPECIES' named entity 'POPULATIONS' named entity 'HAVE' named entity 'CHILDREN' named entity 'CHARACTERISTICS' named entity 'INFECTION' named entity 'HUMAN RHINOVIRUS' named entity 'INFLUENZA-LIKE ILLNESS' named entity 'CHARACTERISTICS' named entity 'HOSPITALIZED PATIENTS' named entity 'CLINICAL' named entity 'CAUSE' named entity 'HRV' named entity 'HEALTHY' named entity 'CHILDREN' named entity 'DISEASE SEVERITY' named entity 'DESCRIBED' covid:arg/51667c85b8b8170c950a1b561b3f2245c3cdce25 named entity 'rhinovirus' named entity 'virologic' named entity 'HRV' named entity 'HRV' named entity 'Epidemiologic' named entity 'cystic fibrosis' named entity 'viral pathogens' named entity 'HRV' named entity 'NCR2' named entity '0.01' named entity 'viral pathogenesis' named entity 'symptom' named entity 'virus' named entity 'infection' named entity 'primers' named entity 'day care centers' named entity 'ARIC' named entity 'Exact test' named entity 'HRV' named entity 'sore throat' named entity 'data collected' named entity 'genotyping' named entity 'Chicago' named entity 'Big Dye terminator' named entity 'COPD' named entity 'sensitivity analysis' named entity 'HRV' named entity 'tested positive' named entity 'symptom' named entity 'HRV' named entity 'HRV' named entity 'physical exam' named entity 'HRV'

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