About: Hydroxychloroquine Proves Ineffective in Hamsters and Macaques Infected with SARS-CoV-2

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An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
title	Hydroxychloroquine Proves Ineffective in Hamsters and Macaques Infected with SARS-CoV-2
Creator	Feldmann, Heinz Feldmann, Friederike Saturday, Greg Okumura, Atsushi Scott, Dana Nason, Martha Haddock, Elaine Rosenke, Kyle Callison, Julie Schwarz, Benjamin Bosio, Catharine De Wit, Emmie Hanley, Patrick Williamson, Brandi Jarvis, Michael Hawman, David Leventhal, Shanna Lovaglio, Jamie Hansen, Frederick Perez-Perez, Lizette Sewell, Graham Tang-Huau, Tsing-Lee Meade-5 White, Kimberly
source	BioRxiv; Medline; PMC; WHO
abstract	We remain largely without effective prophylactic/therapeutic interventions for COVID-19. Although many human clinical trials are ongoing, there remains a deficiency of supportive preclinical drug efficacy studies. Here we assessed the prophylactic/therapeutic efficacy of hydroxychloroquine (HCQ), a drug of interest for COVID-19 management, in two animal models. When used for prophylaxis or treatment neither the standard human malaria dose (6.5 mg/kg) nor a high dose (50 mg/kg) of HCQ had any beneficial effect on clinical disease or SARS-CoV-2 kinetics (replication/shedding) in the Syrian hamster disease model. Similarly, HCQ prophylaxis/treatment (6.5 mg/kg) did not significantly benefit clinical outcome nor reduce SARS-CoV-2 replication/shedding in the upper and lower respiratory tract in the rhesus macaque disease model. In conclusion, our preclinical animal studies do not support the use of HCQ in prophylaxis/treatment of COVID-19.
has issue date	2020-06-11(xsd:dateTime)
bibo:doi	10.1101/2020.06.10.145144
bibo:pmid	32577633
has license	cc-by-nc-nd
sha1sum (hex)	516ec6346b0c0555663e3a74d3db40bd2c8fcf38
schema:url	https://doi.org/10.1101/2020.06.10.145144
resource representing a document's title	Hydroxychloroquine Proves Ineffective in Hamsters and Macaques Infected with SARS-CoV-2
has PubMed Central identifier	PMC7301902
has PubMed identifier	32577633
schema:publication	bioRxiv
resource representing a document's body	covid:516ec6346b0c0555663e3a74d3db40bd2c8fcf38#body_text
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