About: Porcine circovirus type 2 upregulates endothelial-derived IL-8 production in porcine iliac artery endothelial cells via the RIG-I/MDA-5/MAVS/JNK signaling pathway

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About: Porcine circovirus type 2 upregulates endothelial-derived IL-8 production in porcine iliac artery endothelial cells via the RIG-I/MDA-5/MAVS/JNK signaling pathway Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
title	Porcine circovirus type 2 upregulates endothelial-derived IL-8 production in porcine iliac artery endothelial cells via the RIG-I/MDA-5/MAVS/JNK signaling pathway
Creator	Wang, Jianfang Zhang, Yonghong Liu, Shiyu Cui, Defeng Hou, Xiaolin Li, Huanrong Li, Qiuming Liu, Fengying Shi, Fengyang Zhou, Shuanghai
source	PMC
abstract	BACKGROUND: Dysfunction of endothelial cells and vascular system is one of the most important pathological changes of porcine circovirus disease (PCVD) caused by porcine circovirus type 2 (PCV2). PCV2-infected endothelial cells can upregulate the production of endothelial-derived IL-8, which can inhibit the maturation of dendritic cells. Endothelial-derived IL-8 has different structural and biological characteristics compared with monocyte-derived IL-8. However, the mechanism of endothelial-derived IL-8 production is still unclear. RESULTS: Key molecules of RIG-I-like signaling pathway RIG-I, MDA-5, MAVS and a key molecule of JNK signaling pathway c-Jun in PCV2-infected porcine iliac artery endothelial cells (PIECs) were upregulated significantly detected with quantitative PCR, Western blot and fluorescence confocal microscopy, while no significant changes were found in NF-κB signaling pathway. Meanwhile, the expression of endothelial-derived IL-8 was downregulated after RIG-I, MDA-5, or MAVS genes in PIECs were knocked down and PIECs were treated by JNK inhibitor. CONCLUSIONS: PCV2 can activate RIG-I/MDA-5/MAVS/JNK signaling pathway to induce the production of endothelial-derived IL-8 in PIECs, which provides an insight into the further study of endothelial dysfunction and vascular system disorder caused by PCV2.
has issue date	2020-07-29(xsd:dateTime)
bibo:doi	10.1186/s12917-020-02486-1
bibo:pmid	32727484
has license	cc-by
sha1sum (hex)	519023c12fdb2484376eafcb9b0726d0b98d53f5
schema:url	https://doi.org/10.1186/s12917-020-02486-1
resource representing a document's title	Porcine circovirus type 2 upregulates endothelial-derived IL-8 production in porcine iliac artery endothelial cells via the RIG-I/MDA-5/MAVS/JNK signaling pathway
has PubMed Central identifier	PMC7392700
has PubMed identifier	32727484
schema:publication	BMC Vet Res
resource representing a document's body	covid:519023c12fdb2484376eafcb9b0726d0b98d53f5#body_text
is schema:about of	named entity 'NF-κB' named entity 'RIG-I' named entity 'fluorescence' named entity 'MAVS' named entity 'PCV2' named entity 'type 2' named entity 'RIG-I' named entity 'MAVS' named entity 'confocal microscopy' named entity 'endothelial dysfunction' named entity 'c-Jun' named entity 'signaling pathway' named entity 'quantitative PCR' named entity 'IL-8' named entity 'Endothelial' named entity 'porcine' named entity 'PCV2' named entity 'RIG-I' named entity 'signaling pathway' named entity 'Porcine circovirus type 2' named entity 'JNK' named entity 'MDA-5' named entity 'endothelial' named entity 'endothelial cells' named entity 'exogenous' named entity 'microarray' named entity 'adapter protein' named entity 'RIG-I' named entity 'cytoplasm' named entity 'IL-8' named entity 'p38' named entity 'PCV2' named entity 'IL-8' named entity 'mRNA' named entity 'standard deviation' named entity 'endothelial dysfunction' named entity 'PCV2' named entity 'siRNA' named entity 'Mouse Hepatitis Virus' named entity 'p38' named entity 'Expert software' named entity 'MDA-5' named entity 'signal pathway' named entity 'endothelial' named entity 'MDA-5' named entity 'SDS-PAGE' named entity 'PCV2' named entity 'JNK' named entity 'p65' named entity 'western blot' named entity 'endothelial' named entity 'PVDF' named entity 'inoculated' named entity 'MAPKs' named entity 'Coronaviridae' named entity 'RIG-I' named entity 'MAVS' named entity 'gray matter' named entity 'siRNA' named entity 'interferon' named entity 'JNK' named entity 'IκBα' named entity 'IκBα' named entity 'supernatant' named entity 'proinflammatory' named entity 'nuclear translocation' named entity '0.01' named entity 'PCV2' named entity 'siRIG' named entity 'endothelial' named entity 'qPCR' named entity 'RNA viruses'

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