About: CD4(+) T-cell counts and interleukin-8 and CCL-5 plasma concentrations discriminate disease severity in children with RSV infection

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About: CD4(+) T-cell counts and interleukin-8 and CCL-5 plasma concentrations discriminate disease severity in children with RSV infection Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

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type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	CD4(+) T-cell counts and interleukin-8 and CCL-5 plasma concentrations discriminate disease severity in children with RSV infection
Creator	Ferwerda, Gerben Warris, Adilia Neeleman, Chris De Groot, Ronald Brand, Hanne Hermans, Peter Preijers, Frank Staal, Frank
Source	Medline; PMC
abstract	BACKGROUND: Current tools to predict the severity of respiratory syncytial virus (RSV) infection might be improved by including immunological parameters. We hypothesized that a combination of inflammatory markers would differentiate between severe and mild disease in RSV-infected children. METHODS: Blood and nasopharyngeal samples from 52 RSV-infected children were collected during acute infection and after recovery. Retrospectively, patients were categorized into three groups based on disease severity: mild (no supportive treatment), moderate (supplemental oxygen and/or nasogastric feeding), and severe (mechanical ventilation). Clinical data, number of flow-defined leukocyte subsets, and cytokine concentrations were compared. RESULTS: Children with severe RSV infection were characterized by young age; lymphocytopenia; increased interleukin (IL)-8, granulocyte colony-stimulating factor (G-CSF), and IL-6 concentrations; and decreased chemokine (C-C motif) ligand (CCL-5) concentrations in plasma. The combination of plasma levels of IL-8 and CCL-5, and CD4(+) T-cell counts, with cutoff values of 67 pg/ml, 13 ng/ml, and 2.3 × 10(6)/ml, respectively, discriminated severe from mild RSV infection with 82% sensitivity and 96% specificity. CONCLUSION: This study demonstrates that the combination of CD4(+) T-cell counts and IL-8 and CCL-5 plasma concentrations correlates with disease severity in RSV-infected children. In addition to clinical features, these immunological markers may be used to assess severity of RSV infection and guide clinical management. SUPPLEMENTARY INFORMATION: The online version of this article (doi:10.1038/pr.2012.163) contains supplementary material, which is available to authorized users.
has issue date	2012-11-19(xsd:dateTime)
bibo:doi	10.1038/pr.2012.163
bibo:pmid	23165450
has license	no-cc
sha1sum (hex)	5201737f68d8ba72808a8ea7e01a0f8b5623db46
schema:url	https://doi.org/10.1038/pr.2012.163
resource representing a document's title	CD4(+) T-cell counts and interleukin-8 and CCL-5 plasma concentrations discriminate disease severity in children with RSV infection
has PubMed Central identifier	PMC7086553
has PubMed identifier	23165450
schema:publication	Pediatr Res
resource representing a document's body	covid:5201737f68d8ba72808a8ea7e01a0f8b5623db46#body_text
is schema:about of	named entity 'severe' named entity 'T-CELL' named entity 'INFLAMMATORY MARKERS' named entity 'PREDICT' named entity 'CD4' covid:arg/5201737f68d8ba72808a8ea7e01a0f8b5623db46 named entity 'SEVERITY' named entity 'ASSOCIATED WITH' named entity 'CCL' named entity 'INTERLEUKIN-8 ' named entity 'VIRAL LOAD' named entity 'MONOINFECTION' named entity 'DISCRIMINATE' named entity 'RSV INFECTION' named entity 'DISEASE SEVERITY' named entity 'CHILDREN' named entity 'CELL COUNTS' named entity 'PLASMA CONCENTRATIONS' named entity 'PARAMETERS' named entity 'INCLUDING' named entity 'BACKGROUND' named entity 'INFECTED' named entity 'TOOLS' named entity 'IMPROVED BY' named entity 'MILD DISEASE' named entity 'COMBINATION' named entity 'MIGHT BE' named entity 'SEVERE' named entity 'IMMUNOLOGICAL' named entity 'CURRENT' named entity 'INFECTION' named entity 'RESPIRATORY SYNCYTIAL VIRUS' named entity 'CHILDREN' named entity 'DIFFERENTIATE' named entity 'RSV' named entity 'RsV' named entity 'mild' named entity 'infection' named entity 'immunological' named entity 'RSV' named entity 'Viral Load' named entity 'nasopharyngeal' named entity 'Immunophenotyping' named entity 'IL-8' named entity 'IL-8' named entity 'IL-6' named entity 'immune response' named entity 'density gradient centrifugation' named entity 'mechanical ventilation' named entity '2.0' named entity 'viruses' named entity 'RSV' named entity 'plasma levels' named entity 'bronchiolitis' named entity '0.01' named entity 'RSV' named entity 'catheter' named entity 'supernatant' named entity '0.01' named entity 'blood cells' named entity 'RSV infection' named entity 'inflammatory mediators' named entity 'oxygen saturations' named entity 'CD8 +' named entity 'IL-8' named entity 'IL-4' named entity 'RsV' named entity 'infection' named entity 'chemokine' named entity 'RSV' named entity 'saline' named entity 'nasopharyngeal' named entity 'biomarkers' named entity 'RSV'

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