About: A combined nucleocapsid vaccine induces vigorous SARS-CD8+ T-cell immune responses

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About: A combined nucleocapsid vaccine induces vigorous SARS-CD8+ T-cell immune responses Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	A combined nucleocapsid vaccine induces vigorous SARS-CD8+ T-cell immune responses
Creator	Aucoin, Susan Azizi, Ali Diaz-Mitoma, Francisco Frost, Rita Ghorbani, Masoud Naas, Turaya Soare, Catalina Tadesse, Helina
Source	Medline; PMC
abstract	Several studies have shown that cell-mediated immune responses play a crucial role in controlling viral replication. As such, a candidate SARS vaccine should elicit broad CD8+ T-cell immune responses. Several groups of mice were immunized alone or in combination with SARS-nucleocapsid immunogen. A high level of specific SARS-CD8+ T-cell response was demonstrated in mice that received DNA encoding the SARS-nucleocapsid, protein and XIAP as an adjuvant. We also observed that co-administration of a plasmid expressing nucleocapsid, recombinant protein and montanide/CpG induces high antibody titers in immunized mice. Moreover, this vaccine approach merits further investigation as a potential candidate vaccine against SARS.
has issue date	2005-08-22(xsd:dateTime)
bibo:doi	10.1186/1479-0556-3-7
bibo:pmid	16115319
has license	cc-by
sha1sum (hex)	5227121ac5523e669cc04c9a8f2660080d995a34
schema:url	https://doi.org/10.1186/1479-0556-3-7
resource representing a document's title	A combined nucleocapsid vaccine induces vigorous SARS-CD8+ T-cell immune responses
has PubMed Central identifier	PMC1249587
has PubMed identifier	16115319
schema:publication	Genet Vaccines Ther
resource representing a document's body	covid:5227121ac5523e669cc04c9a8f2660080d995a34#body_text
is schema:about of	named entity 'high level' named entity 'vaccine' named entity 'vaccine' named entity 'T-cell' named entity 'T-cell' named entity 'VACCINE' named entity 'PLASMID' named entity 'VACCINE' named entity 'MEDIATED' named entity 'PROTEIN ' named entity 'INVESTIGATION' named entity 'IMMUNIZED' named entity 'RECOMBINANT PROTEIN' named entity 'ADMINISTRATION' named entity 'ROLE' named entity 'VIRAL REPLICATION' named entity 'SARS VACCINE' named entity 'GROUPS' named entity 'CELL RESPONSE' named entity 'POTENTIAL' named entity 'XIAP' named entity 'SPECIFIC' named entity 'ANTIBODY TITERS' named entity 'CANDIDATE' named entity 'PLAY' named entity 'ELICIT' named entity 'DNA' named entity 'IMMUNE RESPONSES' named entity 'DEMONSTRATED' named entity 'HIGH' named entity 'SARS' named entity 'CONTROLLING' named entity 'ADJUVANT' named entity 'T-CELL' covid:arg/5227121ac5523e669cc04c9a8f2660080d995a34 named entity 'APPROACH' named entity 'GENETIC' named entity 'CELL' named entity 'VACCINES' named entity 'T-CELL' named entity 'IMMUNE RESPONSES' named entity 'SARS' named entity 'VIGOROUS' named entity 'THERAPY' named entity 'BROAD' named entity 'CD8' named entity 'MICE' named entity 'NUCLEOCAPSID' named entity 'HAVE' named entity 'HIGH LEVEL' named entity 'COMBINED' named entity 'IMMUNOGEN' named entity 'RECEIVED' named entity 'COMBINATION' named entity 'NUCLEOCAPSID' named entity 'CD8' named entity 'ENCODING' named entity 'OBSERVED' named entity 'STUDIES' named entity 'combination' named entity 'demonstrated' named entity 'immunized' named entity 'received' named entity 'CD8+' named entity 'T-cell' named entity 'potential' named entity 'mice' named entity 'induces' named entity 'nucleocapsid' named entity 'vaccine' named entity 'SARS' named entity 'mice' named entity 'CD8+ T-cell' named entity 'viral replication'

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