About: Comparative sequence analysis of full-length genome of FIPV at different tissue passage levels

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About: Comparative sequence analysis of full-length genome of FIPV at different tissue passage levels Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Comparative sequence analysis of full-length genome of FIPV at different tissue passage levels
Creator	Hilt, D Jackwood, • Phillips, J
Source	Medline; PMC
abstract	Feline infectious peritonitis virus (FIPV), an alpha Coronavirus, is the causative agent of a fatal immune mediated disease in cats. It is currently unclear if this virus circulates in the field or develops in felines that are infected with Feline enteric coronavirus. To better understand the genomic changes associated with viral adaptation, we sequenced the complete genomes of FIPV WSU 79-1146 at different tissue passage levels: passage 1, passage 8, and passage 50 tissue culture. Twenty-one amino acid differences were observed in the polyprotein 1a/ab between the different passages. Only one residue change was observed in the spike glycoprotein, which reverted back on subsequent passages, four changes were observed in the 3c protein, and one change was observed in each 3a, small membrane, nucleocapsid and 7a proteins. The mutation rate was calculated to be 5.08–6.3 × 10(−6) nucleotides/site/passage in tissue culture suggesting a relatively stable virus. Our data show that FIPV has a low mutation rate as it is passed in cell culture but has the capacity for change specifically in nsp 2, 3c, and 7b as it is passed in cell culture.
has issue date	2013-08-31(xsd:dateTime)
bibo:doi	10.1007/s11262-013-0972-5
bibo:pmid	23996606
has license	no-cc
sha1sum (hex)	525be7131f11b5f6af1f7f3614cac25001d85621
schema:url	https://doi.org/10.1007/s11262-013-0972-5
resource representing a document's title	Comparative sequence analysis of full-length genome of FIPV at different tissue passage levels
has PubMed Central identifier	PMC7089344
has PubMed identifier	23996606
schema:publication	Virus Genes
resource representing a document's body	covid:525be7131f11b5f6af1f7f3614cac25001d85621#body_text
is schema:about of	named entity 'adaptation' named entity 'sequenced' named entity 'protein' named entity 'develops' named entity 'virus' named entity 'observed' named entity 'passages' named entity 'causative' named entity 'TISSUE' named entity 'CURRENTLY' named entity 'FELINE ENTERIC CORONAVIRUS' named entity 'BUT' named entity 'MUTATION RATE' named entity 'NUCLEOTIDES' named entity 'DATA' named entity 'CHANGE' named entity 'CAPACITY' named entity 'POLYPROTEIN' named entity 'LENGTH' named entity 'CALCULATED' named entity 'GENOME' named entity 'DIFFERENT' named entity 'AMINO ACID' named entity 'STABLE' named entity 'CIRCULATES' named entity 'CORONAVIRUS' named entity 'GENOMIC' named entity 'UNCLEAR' named entity 'PASSAGE' named entity 'FIPV' named entity 'TISSUE CULTURE' named entity 'CAUSATIVE AGENT' named entity 'COMPLETE' named entity 'GENOMES' named entity 'CATS' named entity 'PASSED' named entity 'LEVELS' named entity 'ALPHA' named entity 'IMMUNE MEDIATED DISEASE' named entity 'SUBSEQUENT' named entity 'PROTEINS' named entity 'DEVELOPS' named entity '1146' named entity 'TWENTY-ONE' named entity 'ASSOCIATED WITH' named entity 'VIRUS' named entity 'IN THE FIELD' named entity 'COMPARATIVE SEQUENCE ANALYSIS' named entity 'LEVELS' named entity 'OBSERVED' named entity 'MEMBRANE' named entity 'LOW' named entity 'CELL CULTURE' named entity 'DIFFERENT' named entity 'FATAL' named entity 'UNDERSTAND' named entity 'OUR' named entity 'VIRAL' named entity 'NSP' named entity 'PASSAGE' named entity 'CHANGES' named entity 'RESIDUE' named entity 'TISSUE' named entity 'SMALL' named entity 'PROTEIN' named entity 'FELINE INFECTIOUS PERITONITIS VIRUS' named entity 'ADAPTATION' named entity 'BETTER' named entity 'INFECTED' named entity 'NUCLEOCAPSID' named entity '6.3' covid:arg/525be7131f11b5f6af1f7f3614cac25001d85621 named entity 'residue' named entity 'virus' named entity 'enteric' named entity 'genomic' named entity 'glycoprotein' named entity 'capacity' named entity 'acid'

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