About: TRAF3 enhances STING-mediated antiviral signaling during the innate immune activation of black carp

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About: TRAF3 enhances STING-mediated antiviral signaling during the innate immune activation of black carp Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

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type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
title	TRAF3 enhances STING-mediated antiviral signaling during the innate immune activation of black carp
Creator	Feng, Hao Wang, Xu Lu, Liang Chen, Song Wu, Hui Li, Wanzhen Song, Xuejiao Xie, Xinchi
source	Elsevier; Medline; PMC
abstract	Abstract Tumor necrosis factor receptor-associated factor 3 (TRAF3) is a main regulator of antiviral and anti-inflammatory pathways in mammals, which is considered to induce type I interferon (IFN) activation and negatively regulate the activation of the canonical and non-canonical NF-κB pathways. To elucidate its function in teleost fish, TRAF3 homologue of black carp (Mylopharyngodon piceus) has been cloned and characterized in this study. The open reading frame (ORF) of black carp TRAF3 (bcTRAF3) consists of 1722 nucleotides and bcTRAF3 contains 574 amino acids. bcTRAF3 protein migrated around 65 KDa in immunoblot analysis of both EPC and HEK293T cells. bcTRAF3 was identified as a cytosolic protein and suggested to form aggregates or be associated with vesicles scattering in the cytoplasm. It was interesting that both NF-κB and IFN transcription was activated by bcTRAF3 in reporter assay. When co-expressed with black carp STING (bcSTING), bcTRAF3 was redistributed in the cytoplasm and its subcellular location overlapped with that of bcSTING no matter what the cells was infected with GCRV or not, which suggested the association between these two molecules. bcSTING-mediated IFN production was up-regulated by bcTRAF3 in a dose dependent manner in reporter assay. Accordingly, EPC cells transfected with both bcSTING and bcTRAF3 showed enhanced antiviral activity comparing EPC cells expressing bcSTING alone. Taken together, the data generated in this paper supported the conclusion that bcTRAF3 was recruited into host innate immune activation and positively regulated bcSTING-mediated antiviral signaling.
has issue date	2018-11-30(xsd:dateTime)
bibo:doi	10.1016/j.dci.2018.07.009
bibo:pmid	30009929
has license	els-covid
sha1sum (hex)	52abe7d93fad5d266e6ceecb808d9e55e37e7e48
schema:url	https://doi.org/10.1016/j.dci.2018.07.009
resource representing a document's title	TRAF3 enhances STING-mediated antiviral signaling during the innate immune activation of black carp
has PubMed Central identifier	PMC7124771
has PubMed identifier	30009929
schema:publication	Developmental & Comparative Immunology
resource representing a document's body	covid:52abe7d93fad5d266e6ceecb808d9e55e37e7e48#body_text
is schema:about of	named entity 'IFN' named entity 'fish' named entity 'nucleotides' named entity 'anti-inflammatory' named entity 'MEDIATED' named entity 'COMPARING' named entity 'SUPPORTED' named entity 'IMMUNE ACTIVATION' named entity 'MATTER' named entity 'ITS' named entity 'HEK293T' named entity 'ACTIVATED' named entity 'PROTEIN ' named entity 'ACTIVATION' named entity 'MIGRATED' named entity 'CELLS' named entity 'SUBCELLULAR LOCATION' named entity 'INFECTED' covid:arg/52abe7d93fad5d266e6ceecb808d9e55e37e7e48 named entity 'CONCLUSION' named entity 'REGULATED' named entity 'VESICLES' named entity 'CHARACTERIZED' named entity 'MAMMALS' named entity 'HOST' named entity 'HOMOLOGUE' named entity 'SCATTERING' named entity 'CLONED' named entity 'WHAT' named entity 'BLACK CARP' named entity 'DOSE' named entity 'NUCLEOTIDES' named entity 'MOLECULES' named entity 'IFN' named entity 'IMMUNOBLOT ANALYSIS' named entity 'INTERFERON ' named entity 'FACTOR' named entity 'STUDY' named entity '574' named entity 'IMMUNE ACTIVATION' named entity 'KDA' named entity 'TYPE I INTERFERON' named entity 'ANTIVIRAL ACTIVITY' named entity 'DEPENDENT' named entity 'ANTIVIRAL' named entity 'GENERATED' named entity 'THESE' named entity 'CONSIDERED' named entity 'AGGREGATES' named entity 'MAIN' named entity 'TUMOR NECROSIS FACTOR RECEPTOR' named entity 'DATA' named entity 'OVERLAPPED' named entity 'TAKEN' named entity 'ANTI-INFLAMMATORY' named entity 'TRAF3' named entity 'ASSOCIATED WITH' named entity 'ASSOCIATION' named entity 'INDUCE' named entity 'ENHANCED' named entity 'BLACK CARP' named entity 'SIGNALING' named entity 'TRAF3' named entity 'ANTIVIRAL' named entity 'FUNCTION' named entity 'PAPER' named entity 'ASSOCIATED' named entity 'CONTAINS' named entity 'NON-' named entity 'REGULATE' named entity 'PRODUCTION' named entity 'CYTOPLASM' named entity 'REGULATOR' named entity 'AMINO ACIDS'

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