About: Central Role of Ubiquitination in Genome Maintenance: DNA Replication and Damage Repair

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An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
title	Central Role of Ubiquitination in Genome Maintenance: DNA Replication and Damage Repair
Creator	Ghosh, Soma Saha, Tapas Montecucco, A Azzalin, C Heus, H
source	Medline; PMC
abstract	Faithful transmission of genetic information through generations ensures genomic stability and integrity. However, genetic alterations occur every now and then during the course of genome duplication. In order to repair these genetic defects and lesions, nature has devised several repair pathways which function promptly to prevent the cell from accumulating permanent mutations. These repair mechanisms seem to be significantly impacted by posttranslational modifications of proteins like phosphorylation and ubiquitination. Protein ubiquitination is emerging as a critical regulatory mechanism of DNA damage response. Non-proteolytic, proteasome-independent functions of ubiquitin involving monoubiquitination and polyubiquitination of DNA repair proteins contribute significantly to the signaling of DNA repair pathways. In this paper, we will particularly highlight the work on ubiquitin-mediated signaling in the repair processes involving the Fanconi anemia pathway, translesional synthesis, nucleotide excision repair, and repair of double-strand breaks. We will also discuss the role of ubiquitin ligases in regulating checkpoint mechanisms, the role of deubiquitinating enzymes, and the growing possibilities of therapeutic intervention in this ubiquitin-conjugation system.
has issue date	2012-02-08(xsd:dateTime)
bibo:doi	10.5402/2012/146748
bibo:pmid	27398234
has license	cc-by
sha1sum (hex)	52bf83ff771d92f697a4ab0cfe70a99503940050
schema:url	https://doi.org/10.5402/2012/146748
resource representing a document's title	Central Role of Ubiquitination in Genome Maintenance: DNA Replication and Damage Repair
has PubMed Central identifier	PMC4908256
has PubMed identifier	27398234
schema:publication	ISRN Mol Biol
resource representing a document's body	covid:52bf83ff771d92f697a4ab0cfe70a99503940050#body_text
is schema:about of	named entity 'DNA REPLICATION' named entity 'UBIQUITINATION' named entity 'THE CELL' named entity 'DUPLICATION' named entity 'PROTEIN UBIQUITINATION' named entity 'MONOUBIQUITINATION' named entity 'WORK' named entity 'CHECKPOINT' named entity 'DISCUSS' named entity 'PROTEOLYTIC' named entity 'ACCUMULATING' named entity 'REGULATORY' named entity 'THERAPEUTIC INTERVENTION' named entity 'PATHWAYS' named entity 'NUCLEOTIDE EXCISION REPAIR' named entity 'MECHANISM' named entity 'NOW AND THEN' named entity 'GENETIC' named entity 'LIKE' named entity 'SYSTEM' named entity 'PERMANENT' named entity 'TO PREVENT' named entity 'TRANSMISSION' named entity 'GENETIC INFORMATION' named entity 'FUNCTION' named entity 'SIGNALING' named entity 'PROCESSES' named entity 'GENOME' named entity 'ORDER' named entity 'CRITICAL' named entity 'GENOMIC STABILITY' named entity 'COURSE' named entity 'STRAND BREAKS' named entity 'NATURE' named entity 'DOUBLE' named entity 'REPAIR' named entity 'GROWING' named entity 'LESIONS' named entity 'PAPER' named entity 'PHOSPHORYLATION' named entity 'GENERATIONS' named entity 'POSTTRANSLATIONAL' named entity 'GENOME MAINTENANCE' named entity 'SYNTHESIS' named entity 'FUNCTIONS' named entity 'REPAIR' named entity 'DAMAGE' named entity 'CENTRAL' named entity 'UBIQUITINATION' named entity 'ROLE' named entity 'NON-' named entity 'ROLE' named entity 'ENSURES' named entity 'OCCUR' named entity 'PROTEASOME' named entity 'ALTERATIONS' named entity 'DNA REPAIR' named entity 'INTEGRITY' named entity 'REGULATING' named entity 'CONTRIBUTE ' named entity 'MUTATIONS' named entity 'UBIQUITIN' named entity 'THESE' named entity 'INVOLVING' named entity 'CONJUGATION' named entity 'INDEPENDENT' named entity 'IMPACTED' named entity 'DEUBIQUITINATING ENZYMES' named entity 'MECHANISMS' named entity 'PROTEINS' named entity 'POLYUBIQUITINATION' named entity 'FANCONI ANEMIA PATHWAY' named entity 'UBIQUITIN LIGASES' named entity 'DNA DAMAGE RESPONSE' covid:arg/52bf83ff771d92f697a4ab0cfe70a99503940050 named entity 'DNA repair pathways' named entity 'proteolytic'

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