About: Cathepsin L is required for ecotropic murine leukemia virus infection in NIH3T3 cells

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About: Cathepsin L is required for ecotropic murine leukemia virus infection in NIH3T3 cells Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

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type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
title	Cathepsin L is required for ecotropic murine leukemia virus infection in NIH3T3 cells
Creator	Yamamoto, Naoki Kubo, Yoshinao Kamiyama, Haruka Goto, Kensuke Katunuma, Nobuhiko Oishi, Kazunori Yoshii, Hiroaki Minematsu, Kazuo Mizota, Tsutomu
source	Elsevier; Medline; PMC
abstract	Abstract Recently it has been reported that a cathepsin B inhibitor, CA-074Me, attenuates ecotropic murine leukemia virus (Eco-MLV) infection in NIH3T3 cells, suggesting that cathepsin B is required for the Eco-MLV infection. However, cathepsin B activity was negative or extremely low in NIH3T3 cells. How did CA-074Me attenuate the Eco-MLV infection? The CA-074Me treatment of NIH3T3 cells inhibited cathepsin L activity, and a cathepsin L specific inhibitor, CLIK148, attenuated the Eco-MLV vector infection. These results indicate that the suppression of cathepsin L activity by CA-074Me induces the inhibition of Eco-MLV infection, suggesting that cathepsin L is required for the Eco-MLV infection in NIH3T3 cells. The CA-074Me treatment inhibited the Eco-MLV infection in human cells expressing the exogenous mouse ecotropic receptor and endogenous cathepsins B and L, but the CLIK148 treatment did not, showing that only the cathepsin L suppression by CLIK148 is not enough to prevent the Eco-MLV infection in cells expressing both of cathepsins B and L, and CA-074Me inhibits the Eco-MLV infection by suppressing both of cathepsins B and L. These results suggest that either cathepsin B or L is sufficient for the Eco-MLV infection.
has issue date	2009-11-25(xsd:dateTime)
bibo:doi	10.1016/j.virol.2009.08.045
bibo:pmid	19781728
has license	els-covid
sha1sum (hex)	52c71df13561ced6eeb229ce7dcab93388b83d2f
schema:url	https://doi.org/10.1016/j.virol.2009.08.045
resource representing a document's title	Cathepsin L is required for ecotropic murine leukemia virus infection in NIH3T3 cells
has PubMed Central identifier	PMC7111982
has PubMed identifier	19781728
schema:publication	Virology
resource representing a document's body	covid:52c71df13561ced6eeb229ce7dcab93388b83d2f#body_text
is schema:about of	named entity 'CATHEPSIN L' named entity 'cathepsins' named entity 'extremely' named entity 'attenuate' named entity 'vector' named entity 'cathepsin B' named entity 'infection' named entity 'infection' named entity 'MURINE LEUKEMIA VIRUS' named entity 'SUPPRESSION' named entity 'EXTREMELY' named entity 'TREATMENT' named entity 'EITHER' named entity 'INFECTION' named entity 'THESE' named entity 'CATHEPSIN L' named entity 'NEGATIVE' named entity 'SPECIFIC' named entity 'ENDOGENOUS' named entity 'CATHEPSIN L ACTIVITY' named entity 'DID' named entity 'ATTENUATE' covid:arg/52c71df13561ced6eeb229ce7dcab93388b83d2f named entity 'RESULTS' named entity 'INHIBITOR' named entity 'SUGGEST' named entity 'VIRUS INFECTION' named entity 'REQUIRED' named entity 'NIH3T3' named entity 'CELLS' named entity 'INHIBITION' named entity 'NIH3T3' named entity 'HUMAN CELLS' named entity 'ECO' named entity 'CELLS' named entity 'REQUIRED' named entity 'CATHEPSIN B' named entity 'SUFFICIENT' named entity 'ATTENUATED' named entity 'MURINE LEUKEMIA VIRUS' named entity 'TO PREVENT' named entity 'SUPPRESSING' named entity 'MLV' named entity 'NOT ENOUGH' named entity 'MOUSE' named entity 'RECEPTOR' named entity 'INHIBITED' named entity 'RECENTLY' named entity 'VECTOR' named entity 'REPORTED' named entity 'BUT' named entity 'LOW' named entity 'HOW' named entity 'CATHEPSIN B INHIBITOR' named entity 'EXOGENOUS' named entity 'CATHEPSIN B ACTIVITY' named entity 'infection' named entity 'specific' named entity 'cathepsin B' named entity 'cathepsin' named entity 'cathepsin' named entity 'cathepsin' named entity 'rat' named entity 'Env' named entity 'Nucleotide sequences' named entity 'cathepsin' named entity 'vector' named entity 'Env' named entity 'These' named entity 'expressing' named entity 'cells' named entity 'cathepsin' named entity 'cathepsin'

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