About: Phenotypic heterogeneity of antigen‐specific CD4 T cells under different conditions of antigen persistence and antigen load

Facets (new session)
Description
Metadata
Settings
- owl:sameAs
- Inference Rule:

About: Phenotypic heterogeneity of antigen‐specific CD4 T cells under different conditions of antigen persistence and antigen load Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Phenotypic heterogeneity of antigen‐specific CD4 T cells under different conditions of antigen persistence and antigen load
Creator	Harari, Alexandre Pantaleo, Giuseppe Vallelian, Florence
Source	Medline; PMC
abstract	The factors responsible for the phenotypic heterogeneity of memory CD4 T cells are unclear. In the present study, we have identified a third population of memory CD4 T cells characterized as CD45RA(+)CCR7(–) that, based on its replication history and the homeostatic proliferative capacity, was at an advanced stage of differentiation. Three different phenotypic patterns of memory CD4 T cell responses were delineated under different conditions of antigen (Ag) persistence and load using CD45RA and CCR7 as markers of memory T cells. Mono‐phenotypic CD45RA(–)CCR7(+) or CD45RA(–)CCR7(–) CD4 T cell responses were associated with conditions of Ag clearance (tetanus toxoid‐specific CD4 T cell response) or Ag persistence and high load (chronic HIV‐1 and primary CMV infections), respectively. Multi‐phenotypic CD45RA(–)CCR7(+), CD45RA(–)CCR7(–) and CD45RA(+)CCR7(–) CD4 T cell responses were associated with protracted Ag exposure and low load (chronic CMV, EBV and HSV infections and HIV‐1 infection in long‐term nonprogressors). The mono‐phenotypic CD45RA(–)CCR7(+) response was typical of central memory (T(CM)) IL‐2‐secreting CD4 T cells, the mono‐phenotypic CD45RA(–)CCR7(–) response of effector memory (T(EM)) IFN‐γ‐secreting CD4 T cells and the multi‐phenotypic response of both IL‐2‐ and IFN‐γ‐secreting cells. The present results indicate that the heterogeneity of different Ag‐specific CD4 T cell responses is regulated by Ag exposure and Ag load.
has issue date	2004-10-14(xsd:dateTime)
bibo:doi	10.1002/eji.200425324
bibo:pmid	15484193
has license	no-cc
sha1sum (hex)	52e49eb8d12486be2f346629cca186fb6b6368cc
schema:url	https://doi.org/10.1002/eji.200425324
resource representing a document's title	Phenotypic heterogeneity of antigen‐specific CD4 T cells under different conditions of antigen persistence and antigen load
has PubMed Central identifier	PMC7163537
has PubMed identifier	15484193
schema:publication	Eur J Immunol
resource representing a document's body	covid:52e49eb8d12486be2f346629cca186fb6b6368cc#body_text
is schema:about of	named entity 'tetanus' named entity 'HIV-1 infection' named entity 'factors' named entity 'conditions' named entity 'central' named entity 'Phenotypic' named entity 'T CELLS' named entity 'HISTORY' named entity 'LONG-TERM' named entity 'CCR7' named entity 'CD4' named entity 'RESPONSES' named entity 'HIGH' named entity 'CMV' named entity 'MEMORY' named entity 'T CELL RESPONSE' named entity 'MULTI' named entity 'DELINEATED' named entity 'PATTERNS' named entity 'EXPOSURE' named entity 'TYPICAL' named entity 'CD4' named entity 'infections' named entity 'long-term nonprogressors' named entity 'memory' named entity 'CD4' named entity 'responses' named entity 'memory' named entity 'load' named entity 'CD4' named entity 'HSV' named entity 'memory' named entity 'CD4 T cells' named entity 'advanced stage' named entity 'HSV' named entity 'CMV' named entity 'HIV-1' named entity 'CD4 T cells' named entity 'IFN' named entity 'central memory' named entity 'IL-2' named entity 'IFN' named entity 'memory T cells' named entity 'antigen' named entity 'persistence' named entity 'HIV-1 infection' named entity 'CD4 T cells' named entity 'EBV' named entity 'CCR7' named entity 'Columbia, MD' named entity 'CD4' named entity 'Epstein-Barr virus' named entity 'CD7' named entity 'eji' named entity 'IFN' named entity 'CCR7' named entity 'phenotypic' named entity 'RPMI 1640' named entity 'tetanus toxoid' named entity 'HIV-1 infection' named entity 'Aventis Pasteur' named entity 'HSV' named entity 'CD4 T cell' named entity 'Institutional Review Board' named entity 'San Diego' named entity 'phenotypic heterogeneity' named entity 'HIV-1 infection' named entity 'terminally differentiated' named entity 'IFN' named entity 'Intracellular' named entity 'memory T cells' named entity 'phenotypically' named entity 'memory T cell' named entity 'randomly selected' named entity 'FITC' named entity 'viremia' named entity 'CD4 T cells' named entity 'phenotypically' named entity 'HIV-1 infection'

Faceted Search & Find service v1.13.91 as of Mar 24 2020

Alternative Linked Data Documents: Sponger | ODE Content Formats:

RDF

ODATA

Microdata

About

OpenLink Virtuoso version 07.20.3229 as of Jul 10 2020, on Linux (x86_64-pc-linux-gnu), Single-Server Edition (94 GB total memory)
Data on this page belongs to its respective rights holders.
Virtuoso Faceted Browser Copyright © 2009-2024 OpenLink Software