About: Multicenter Evaluation of the BioFire FilmArray Pneumonia/Pneumonia Plus Panel for Detection and Quantification of Agents of Lower Respiratory Tract Infection

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About: Multicenter Evaluation of the BioFire FilmArray Pneumonia/Pneumonia Plus Panel for Detection and Quantification of Agents of Lower Respiratory Tract Infection Goto Sponge NotDistinct Permalink

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type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
title	Multicenter Evaluation of the BioFire FilmArray Pneumonia/Pneumonia Plus Panel for Detection and Quantification of Agents of Lower Respiratory Tract Infection
Creator	Rogatcheva, Margarita Leber, Amy Everhart, Kathy Harrington, Amanda Kwong, Christina Naccache, Samia Relich, Ryan Bourzac, Kevin Humphries, Romney Bard, Jennifer Jones, Barbara Buchan, Blake Akerele, Oluseun Bonwit, Andrew Buccambuso, Maggie Buckner, Rebecca Campeau, Shelly Carroll, Amanda Chandrasekaran, Suki Clark, Angela Fowler, Randal Graue, Corrin Hopp, Amanda Huse, Holly Miquel Balada-Llasat, Joan Murphy, Caitlin Rindlisbacher, Cory Ronen, Shira Stone, Hanna Warren, Del Windham, Sam Zimmerman, Cynthia
source	Medline; PMC
abstract	The ability to provide timely identification of the causative agents of lower respiratory tract infections can promote better patient outcomes and support antimicrobial stewardship efforts. Current diagnostic testing options include culture, molecular testing, and antigen detection. These methods may require collection of various specimens, involve extensive sample treatment, and can suffer from low sensitivity and long turnaround times. This study assessed the performance of the BioFire FilmArray Pneumonia Panel (PN panel) and Pneumonia Plus Panel (PNplus panel), an FDA-cleared sample-to-answer assay that enables the detection of viruses, atypical bacteria, bacteria, and antimicrobial resistance marker genes from lower respiratory tract specimens (sputum and bronchoalveolar lavage [BAL] fluid). Semiquantitative results are also provided for the bacterial targets. This paper describes selected analytical and clinical studies that were conducted to evaluate performance of the panel for regulatory clearance. Prospectively collected respiratory specimens (846 BAL and 836 sputum specimens) evaluated with the PN panel were also tested by quantitative reference culture and molecular methods for comparison. The PN panel showed a sensitivity of 100% for 15/22 etiologic targets using BAL specimens and for 10/24 using sputum specimens. All other targets had sensitivities of ≥75% or were unable to be calculated due to low prevalence in the study population. Specificity for all targets was ≥87.2%, with many false-positive results compared to culture that were confirmed by alternative molecular methods. Appropriate adoption of this test could provide actionable diagnostic information that is anticipated to impact patient care and antimicrobial stewardship decisions.
has issue date	2020-06-24(xsd:dateTime)
bibo:doi	10.1128/jcm.00128-20
bibo:pmid	32350043
has license	cc-by
sha1sum (hex)	53350e9c4aca69dcb9ff9c5339ada938a9066ef7
schema:url	https://doi.org/10.1128/jcm.00128-20
resource representing a document's title	Multicenter Evaluation of the BioFire FilmArray Pneumonia/Pneumonia Plus Panel for Detection and Quantification of Agents of Lower Respiratory Tract Infection
has PubMed Central identifier	PMC7315029
has PubMed identifier	32350043
schema:publication	J Clin Microbiol
resource representing a document's body	covid:53350e9c4aca69dcb9ff9c5339ada938a9066ef7#body_text
is schema:about of	named entity 'detection' named entity 'performance' named entity 'Pneumonia' named entity 'study population' named entity 'evaluated' covid:arg/53350e9c4aca69dcb9ff9c5339ada938a9066ef7 named entity 'panel' named entity 'causative' named entity 'culture' named entity 'bacterial' named entity 'specimens' named entity 'quantitative' named entity 'respiratory tract' named entity 'bacteria' named entity 'adoption' named entity 'sputum' named entity 'Panel' named entity 'bacteria' named entity 'molecular testing' named entity 'antimicrobial stewardship' named entity 'diagnostic testing' named entity 'Pneumonia' named entity 'care' named entity 'chromosomally' named entity 'ventilator-associated pneumonia' named entity 'gene markers' named entity 'true positive' named entity 'organism' named entity 'CTX-M' named entity 'phenotypes' named entity 'E. coli' named entity 'SCCmec' named entity 'AST' named entity 'coronavirus' named entity '3.5' named entity 'expectorated' named entity 'nucleic acid' named entity 'Staphylococcus aureus' named entity 'HRV' named entity 'multiplex PCR' named entity 'bacteria' named entity 'epidemiological' named entity 'antibiotics' named entity 'Roche Diagnostics' named entity 'lower respiratory tract' named entity 'sterile physiological saline' named entity 'panel testing' named entity 'methicillin' named entity 'pathogens' named entity 'false-positive'

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