About: Synthesis and antiviral evaluation of acyclic azanucleosides developed from sulfanilamide as a lead structure

Facets (new session)
Description
Metadata
Settings
- owl:sameAs
- Inference Rule:

About: Synthesis and antiviral evaluation of acyclic azanucleosides developed from sulfanilamide as a lead structure Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
title	Synthesis and antiviral evaluation of acyclic azanucleosides developed from sulfanilamide as a lead structure
Creator	De Clercq, Erik Naesens, Lieve Gawin, Rafał Koszytkowska-Stawiń Ska, Mariola
topic	covid:533c42ebe8e0f65ba71ac16d1be41674a674bf49#this
source	Elsevier; Medline; PMC
abstract	Abstract The acyclic azanucleosides with 2-, 3-, or 4-aminobenzenesulfonyl function at the nitrogen atom of the sugar mimic were prepared by coupling of 2-, 3-, or 4-nitro-N-(2-pivaloyloxyethyl)-N-(pivaloyloxymethyl)benzenesulfonamide with the silylated pyrimidine nucleobases followed by the reduction of the nitro group with sodium dithionite in aqueous solution or the palladium-catalysed transfer hydrogenation. The azanucleosides were evaluated for, but found to be devoid of, activity against several RNA- and DNA-viruses in vitro.
has issue date	2008-09-15(xsd:dateTime)
bibo:doi	10.1016/j.bmc.2008.08.041
bibo:pmid	18778942
has license	els-covid
sha1sum (hex)	533c42ebe8e0f65ba71ac16d1be41674a674bf49
schema:url	https://doi.org/10.1016/j.bmc.2008.08.041
resource representing a document's title	Synthesis and antiviral evaluation of acyclic azanucleosides developed from sulfanilamide as a lead structure
has PubMed Central identifier	PMC7127773
has PubMed identifier	18778942
schema:publication	Bioorganic & Medicinal Chemistry
resource representing a document's body	covid:533c42ebe8e0f65ba71ac16d1be41674a674bf49#body_text
is http://vocab.deri.ie/void#inDataset of	proxy:http/ns.inria.fr/covid19/533c42ebe8e0f65ba71ac16d1be41674a674bf49
is schema:about of	named entity 'SUGAR' named entity 'NITRO' named entity 'FOLLOWED BY' named entity 'FOUND' named entity 'IN VITRO' named entity 'NITROGEN ATOM' named entity '282' named entity 'SYNTHESIS' named entity 'PREPARED' named entity 'ACYCLIC' named entity 'ACYCLIC' named entity 'REDUCTION' named entity 'SODIUM DITHIONITE' named entity 'EVALUATED' named entity 'PALLADIUM' named entity 'NITRO GROUP' named entity 'RNA' named entity 'FUNCTION' named entity 'COUPLING' named entity 'LEAD' named entity 'ANTIVIRAL' named entity 'TRANSFER HYDROGENATION' named entity 'ACTIVITY' named entity 'EVALUATION' named entity 'PYRIMIDINE NUCLEOBASES' named entity 'SULFANILAMIDE' named entity 'BUT' named entity 'STRUCTURE' named entity 'AQUEOUS SOLUTION' named entity 'MIMIC' named entity 'pivaloyloxymethyl' named entity 'nitrogen atom' named entity 'transfer hydrogenation' named entity 'palladium' named entity 'RNA' named entity 'lead structure' named entity 'sodium dithionite' named entity 'uracil' named entity 'RNA' named entity 'cytopathic effect' named entity 'mmol' named entity 'cell morphology' named entity 'nitro' named entity 'NH 2' named entity 'acetic acid' named entity 'acetone' named entity 'pivalate' named entity 'acyl' named entity 'uracil' named entity 'mmol' named entity 'nitro' named entity 'chloroform' named entity 'mmol' named entity 'Chromatographic purification' named entity 'hydrogenation' named entity 'amorphous solid' named entity 'biological activities' named entity 'ammonium hydroxide' named entity 'silica gel' named entity 'column chromatography' named entity 'nickel(II) chloride' named entity 'acetone' named entity 'brine' named entity 'chloride' named entity 'nucleobase' named entity 'pivaloyl chloride' named entity 'ammonolysis' named entity 'acetamido' named entity '5-fluorouracil' named entity 'sulfonamides' named entity 'cyclohexene' named entity 'sodium dithionite' named entity 'viruses' named entity 'acetamido' named entity 'hexane' named entity 'nitro'

Faceted Search & Find service v1.13.91 as of Mar 24 2020

Alternative Linked Data Documents: Sponger | ODE Content Formats:

RDF

ODATA

Microdata

About

OpenLink Virtuoso version 07.20.3229 as of Jul 10 2020, on Linux (x86_64-pc-linux-gnu), Single-Server Edition (94 GB total memory)
Data on this page belongs to its respective rights holders.
Virtuoso Faceted Browser Copyright © 2009-2025 OpenLink Software