About: Proenkephalin, Neutrophil Gelatinase-Associated Lipocalin, and Estimated Glomerular Filtration Rates in Patients With Sepsis

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About: Proenkephalin, Neutrophil Gelatinase-Associated Lipocalin, and Estimated Glomerular Filtration Rates in Patients With Sepsis Goto Sponge NotDistinct Permalink

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type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
title	Proenkephalin, Neutrophil Gelatinase-Associated Lipocalin, and Estimated Glomerular Filtration Rates in Patients With Sepsis
Creator	Bergmann, Andreas Cardelli, Patrizia Hartmann, Oliver Hur, Mina Kim, Hanah Lee, Seungho Magrini, Laura Marino, Rossella Struck, Joachim Rome, La Somma, Salvatore
source	PMC
abstract	BACKGROUND: Proenkephalin (PENK) has been suggested as a novel biomarker for kidney function. We investigated the diagnostic and prognostic utility of plasma PENK in comparison with neutrophil gelatinase-associated lipocalin (NGAL) and estimated glomerular filtration rates (eGFR) in septic patients. METHODS: A total of 167 septic patients were enrolled: 99 with sepsis, 37 with septic shock, and 31 with suspected sepsis. PENK and NGAL concentrations were measured and GFR was estimated by using the isotope dilution mass spectrometry traceable-Modification of Diet in Renal Disease (MDRD) Study and three Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI) equations: CKD-EPI(Cr), CDK-EPI(CysC), and CKD-EPI(Cr-CysC). The PENK, NGAL, and eGFR results were compared according to sepsis severity, presence or absence of acute kidney injury (AKI), and clinical outcomes. RESULTS: The PENK, NGAL, and eGFR results were significantly associated with sepsis severity and differed significantly between patients with and without AKI only in the sepsis group (all P<0.05). PENK was superior to NGAL in predicting AKI (P=0.022) and renal replacement therapy (RRT) (P=0.0085). Regardless of the variable GFR category by the different eGFR equations, PENK showed constant and significant associations with all eGFR equations. Unlike NGAL, PENK was not influenced by inflammation and predicted the 30-day mortality. CONCLUSIONS: PENK is a highly sensitive and objective biomarker of AKI and RRT and is useful for prognosis prediction in septic patients. With its diagnostic robustness and predictive power for survival, PENK constitutes a promising biomarker in critical care settings including sepsis.
has issue date	2017-06-20(xsd:dateTime)
bibo:doi	10.3343/alm.2017.37.5.388
bibo:pmid	28643487
has license	cc-by-nc
sha1sum (hex)	533f8d39de2e16fb92614d2441621e8fddd85bbe
schema:url	https://doi.org/10.3343/alm.2017.37.5.388
resource representing a document's title	Proenkephalin, Neutrophil Gelatinase-Associated Lipocalin, and Estimated Glomerular Filtration Rates in Patients With Sepsis
has PubMed Central identifier	PMC5500737
has PubMed identifier	28643487
schema:publication	Ann Lab Med
resource representing a document's body	covid:533f8d39de2e16fb92614d2441621e8fddd85bbe#body_text
is schema:about of	named entity 'ESTIMATED' named entity 'ARTICLE' named entity 'GLOMERULAR FILTRATION' named entity 'RATES' named entity 'PENK' named entity 'PROGNOSTIC' named entity 'PATIENTS' named entity 'NEUTROPHIL GELATINASE-ASSOCIATED LIPOCALIN' named entity 'RATES' named entity 'PROENKEPHALIN' named entity 'PROENKEPHALIN' named entity 'NOVEL' named entity 'DIAGNOSTIC' named entity 'ESTIMATED' named entity 'NEUTROPHIL GELATINASE-ASSOCIATED LIPOCALIN' named entity 'SEPSIS' named entity 'GLOMERULAR FILTRATION' named entity 'KIDNEY FUNCTION' named entity 'COMPARISON' named entity 'SEPTIC' named entity 'BACKGROUND' named entity 'INVESTIGATED' named entity 'CLINICAL CHEMISTRY' named entity 'PLASMA' named entity 'ORIGINAL' named entity 'PATIENTS' named entity 'UTILITY' named entity 'BIOMARKER' covid:arg/533f8d39de2e16fb92614d2441621e8fddd85bbe named entity 'neutrophil gelatinase-associated lipocalin' named entity 'prognostic' named entity 'eGFR' named entity 'eGFR' named entity 'NGAL' named entity 'oxidant stress' named entity 'eGFR' named entity 'glomerular filtration rate' named entity 'cut-offs' named entity 'Surviving Sepsis Campaign' named entity 'NGAL' named entity 'MDRD' named entity 'proenkephalin' named entity 'pmol/L' named entity 'eGFR' named entity 'eGFR' named entity 'multiple comparisons' named entity 'ROC curves' named entity 'eGFR' named entity 'critical care' named entity 'sepsis' named entity 'AKI' named entity 'NGAL' named entity 'reference method' named entity 'NGAL' named entity 'ROC curves' named entity 'dialyzed' named entity 'gene' named entity 'ROC curve' named entity 'AKI' named entity 'sepsis' named entity 'RRT' named entity 'biomarker' named entity 'significant difference' named entity 'septic shock' named entity 'life-threatening' named entity 'RRT' named entity 'NGAL' named entity 'GFR' named entity 'Serum' named entity 'chronic renal insufficiency' named entity 'eGFR'

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