About: Rapid systematic review of neonatal COVID-19 including a case of presumed vertical transmission

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An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
title	Rapid systematic review of neonatal COVID-19 including a case of presumed vertical transmission
Creator	Ahmed, M Gordon, Gordon, Morris Rawlingson, Chris Rezk, Karim Guleri, Dr Taher Kagalwala,
source	Medline; PMC
abstract	OBJECTIVE: To carry out a systematic review of the available studies on COVID-19 (coronavirus disease 2019) in neonates seen globally since the onset of the COVID-19 global pandemic in 2020. The paper also describes a premature baby with reverse transcription (RT)-PCR-positive COVID-19 seen at the Blackpool Teaching Hospitals NHS Foundation Trust, UK. DESIGN: We conducted a multifaceted search of the Cumulative Index to Nursing and Allied Health Literature, Embase, Medline and PubMed from 1 December 2019 to 12 May 2020 to harvest articles from medical journals and publications reporting cases of COVID-19 in neonates from anywhere in the world. Additional searches were also done so as not to miss any important publications. Write-up was in line with the Preferred Reporting Items for Systematic Reviews and Meta-Analyses, the protocol for the review was registered with International Prospective Register of Systematic Reviews (PROSPERO), and risk of bias was analysed with the Newcastle-Ottawa tool. Additionally, the preterm neonate with COVID-19 from our hospital is also reported. RESULTS: The systematic review has revealed eight studies where neonates have been described to have confirmed COVID-19, with low risk of bias. Of the 10 reported cases elsewhere, only three are likely to be vertically transmitted, while seven occurred in the postperinatal period and are likely to have been postnatally acquired. All neonates had a mild course, recovered fully and were negative on retesting. Our case of COVID-19 in a 32-week premature baby from the UK was delivered by emergency caesarean section, with the mother wearing a face mask and the family having no contact with the neonate, suggesting vertical transmission. On day 33, the neonate was asymptomatic but was still RT-PCR-positive on nasopharyngeal airway swab. CONCLUSIONS: Neonatal infection is uncommon, with only two previously reported cases likely to be of vertical transmission. The case we report is still RT-PCR-positive on day 28 and is asymptomatic. Ongoing research is needed to ascertain the epidemiology of COVID-19 in neonates.
has issue date	2020-05-25(xsd:dateTime)
bibo:doi	10.1136/bmjpo-2020-000718
bibo:pmid	32574345
has license	cc-by-nc
sha1sum (hex)	535c6325c2bb98fdb51afb3978ae3851a34f0b26
schema:url	https://doi.org/10.1136/bmjpo-2020-000718
resource representing a document's title	Rapid systematic review of neonatal COVID-19 including a case of presumed vertical transmission
has PubMed Central identifier	PMC7252972
has PubMed identifier	32574345
schema:publication	BMJ Paediatr Open
resource representing a document's body	covid:535c6325c2bb98fdb51afb3978ae3851a34f0b26#body_text
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