About: Genetic resistance - an alternative for controlling PRRS?

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An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Genetic resistance - an alternative for controlling PRRS?
Creator	Reiner, Gerald
Source	PMC
abstract	PRRS is one of the most challenging diseases for world-wide pig production. Attempts for a sustainable control of this scourge by vaccination have not yet fully satisfied. With an increasing knowledge and methodology in disease resistance, a new world-wide endeavour has been started to support the combat of animal diseases, based on the existence of valuable gene variants with regard to any host-pathogen interaction. Several groups have produced a wealth of evidence for natural variability in resistance/susceptibility to PRRS in our commercial breeding lines. However, up to now, exploiting existing variation has failed because of the difficulty to detect the carriers of favourable and unfavourable alleles, especially with regard to such complex polygenic traits like resistance to PRRS. New hope comes from new genomic tools like next generation sequencing which have become extremely fast and low priced. Thus, research is booming world-wide and the jigsaw puzzle is filling up – slowly but steadily. On the other hand, knowledge from virological and biomedical basic research has opened the way for an “intervening way”, i.e. the modification of identified key genes that occupy key positions in PRRS pathogenesis, like CD163. CD163 was identified as the striking receptor in PRRSV entry and its knockout from the genome by gene editing has led to the production of pigs that were completely resistant to PRRSV – a milestone in modern pig breeding. However, at this early step, concerns remain about the acceptance of societies for gene edited products and regulation still awaits upgrading to the new technology. Further questions arise with regard to upcoming patents from an ethical and legal point of view. Eventually, the importance of CD163 for homeostasis, defence and immunity demands for more insight before its complete or partial silencing can be answered. Whatever path will be followed, even a partial abolishment of PRRSV replication will lead to a significant improvement of the disastrous herd situation, with a significant impact on welfare, performance, antimicrobial consumption and consumer protection. Genetics will be part of a future solution.
has issue date	2016-11-16(xsd:dateTime)
bibo:doi	10.1186/s40813-016-0045-y
bibo:pmid	28405453
has license	cc-by
sha1sum (hex)	5390aefc8bb1a06635a321c0cd82589e2b91c9ee
schema:url	https://doi.org/10.1186/s40813-016-0045-y
resource representing a document's title	Genetic resistance - an alternative for controlling PRRS?
has PubMed Central identifier	PMC5382513
has PubMed identifier	28405453
schema:publication	Porcine Health Manag
resource representing a document's body	covid:5390aefc8bb1a06635a321c0cd82589e2b91c9ee#body_text
is schema:about of	named entity 'defence' named entity 'performance' named entity 'resistance' named entity 'regard' named entity 'PRRS' named entity 'variation' named entity 'susceptibility' named entity 'resistance' named entity 'diseases' named entity 'breeding' named entity 'PRRS' named entity 'evidence' named entity 'alternative' named entity 'PRRS' named entity 'GENETIC RESISTANCE' named entity 'NATURAL' named entity 'STEP' named entity 'VARIANTS' named entity 'WAY' named entity 'HOMEOSTASIS' named entity 'PART OF' named entity 'GENETICS' named entity 'WELFARE' named entity 'POINT OF VIEW' named entity 'ONE OF' named entity 'METHODOLOGY' named entity 'SOCIETIES' named entity 'HOST-PATHOGEN INTERACTION' named entity 'PRODUCTS' named entity 'SITUATION' named entity 'PRODUCTION' named entity 'VARIATION' named entity 'RESISTANT TO' named entity 'MODIFICATION' named entity 'EDITED' named entity 'PIGS' named entity 'TOOLS' named entity 'GENE' named entity 'SATISFIED' named entity 'SCOURGE' named entity 'NEXT GENERATION SEQUENCING' named entity 'OPENED' named entity 'LINES' named entity 'GENE EDITING' named entity 'SIGNIFICANT' named entity 'KNOCKOUT' named entity 'CONSUMER PROTECTION' named entity 'TO DETECT' named entity 'DIFFICULTY' named entity 'STRIKING' named entity 'OUR' named entity 'REGARD' named entity 'RESISTANCE TO' named entity 'COMMERCIAL' named entity 'GENOMIC' named entity 'DISEASES' named entity 'PRRS' named entity 'RECEPTOR' named entity 'OF EVIDENCE' named entity 'BREEDING' named entity 'EXTREMELY' named entity 'SOLUTION' named entity 'BASED' named entity 'EARLY' named entity 'RESISTANCE' named entity 'LEGAL' named entity 'GROUPS' named entity 'CONCERNS' named entity 'ACCEPTANCE' named entity 'LOW' named entity 'PARTIAL' named entity 'LEAD' named entity 'HAND' named entity 'SIGNIFICANT IMPROVEMENT' named entity 'ALLELES' named entity 'HOPE' named entity 'ITS' named entity 'FAILED' named entity 'JIGSAW PUZZLE' named entity 'DEMANDS' named entity 'STARTED'

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