About: Clinical characteristics of fatal and recovered cases of coronavirus disease 2019 in Wuhan, China: a retrospective study

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An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Clinical characteristics of fatal and recovered cases of coronavirus disease 2019 in Wuhan, China: a retrospective study
Creator	Wang, Ke Zhou, Ling Liu, Wei Liu, Kui Chen, Lei Liu, Hui-Guo Deng, Yan Fang, Yuan-Yuan Liu, Wei, Shuang Hui-Guo, Leng, Fan Shang, Jin
Source	Medline; PMC; WHO
abstract	BACKGROUND: The 2019 novel coronavirus has caused the outbreak of the acute respiratory disease in Wuhan, Hubei Province of China since December 2019. This study was performed to analyze the clinical characteristics of patients who succumbed to and who recovered from 2019 novel coronavirus disease (COVID-19). METHODS: Clinical data were collected from two tertiary hospitals in Wuhan. A retrospective investigation was conducted to analyze the clinical characteristics of fatal cases of COVID-19 (death group) and we compare them with recovered patients (recovered group). Continuous variables were analyzed using the Mann-Whitney U test. Categorical variables were analyzed by χ(2) test or Fisher exact test as appropriate. RESULTS: Our study enrolled 109 COVID-19 patients who died during hospitalization and 116 recovered patients. The median age of the death group was older than the recovered group (69 [62, 74] vs. 40 [33, 57] years, Z = 9.738, P < 0.001). More patients in the death group had underlying diseases (72.5% vs. 41.4%, χ(2) = 22.105, P < 0.001). Patients in the death group had a significantly longer time of illness onset to hospitalization (10.0 [6.5, 12.0] vs. 7.0 [5.0, 10.0] days, Z = 3.216, P = 0.001). On admission, the proportions of patients with symptoms of dyspnea (70.6% vs. 19.0%, χ(2) = 60.905, P < 0.001) and expectoration (32.1% vs. 12.1%, χ(2) = 13.250, P < 0.001) were significantly higher in the death group. The blood oxygen saturation was significantly lower in the death group (85 [77, 91]% vs. 97 [95, 98]%, Z = 10.625, P < 0.001). The white blood cell (WBC) in death group was significantly higher on admission (7.23 [4.87, 11.17] vs. 4.52 [3.62, 5.88] ×10(9)/L, Z = 7.618, P < 0.001). Patients in the death group exhibited significantly lower lymphocyte count (0.63 [0.40, 0.79] vs. 1.00 [0.72, 1.27] ×10(9)/L, Z = 8.037, P < 0.001) and lymphocyte percentage (7.10 [4.45, 12.73]% vs. 23.50 [15.27, 31.25]%, Z = 10.315, P < 0.001) on admission, and the lymphocyte percentage continued to decrease during hospitalization (7.10 [4.45, 12.73]% vs. 2.91 [1.79, 6.13]%, Z = 5.242, P < 0.001). Alanine transaminase (22.00 [15.00, 34.00] vs. 18.70 [13.00, 30.38] U/L, Z = 2.592, P = 0.010), aspartate transaminase (34.00 [27.00, 47.00] vs. 22.00 [17.65, 31.75] U/L, Z = 7.308, P < 0.001), and creatinine levels (89.00 [72.00, 133.50] vs. 65.00 [54.60, 78.75] μmol/L, Z = 6.478, P < 0.001) were significantly higher in the death group than those in the recovered group. C-reactive protein (CRP) levels were also significantly higher in the death group on admission (109.25 [35.00, 170.28] vs. 3.22 [1.04, 21.80] mg/L, Z = 10.206, P < 0.001) and showed no significant improvement after treatment (109.25 [35.00, 170.28] vs. 81.60 [27.23, 179.08] mg/L, Z = 1.219, P = 0.233). The patients in the death group had more complications such as acute respiratory distress syndrome (ARDS) (89.9% vs. 8.6%, χ(2) = 148.105, P < 0.001), acute cardiac injury (59.6% vs. 0.9%, χ(2) = 93.222, P < 0.001), acute kidney injury (18.3% vs. 0%, χ(2) = 23.257, P < 0.001), shock (11.9% vs. 0%, χ(2) = 14.618, P < 0.001), and disseminated intravascular coagulation (DIC) (6.4% vs. 0%, χ(2) = 7.655, P = 0.006). CONCLUSIONS: Compared to the recovered group, more patients in the death group exhibited characteristics of advanced age, pre-existing comorbidities, dyspnea, oxygen saturation decrease, increased WBC count, decreased lymphocytes, and elevated CRP levels. More patients in the death group had complications such as ARDS, acute cardiac injury, acute kidney injury, shock, and DIC.
has issue date	2020-06-05(xsd:dateTime)
bibo:doi	10.1097/cm9.0000000000000824
bibo:pmid	32209890
has license	cc-by-nc-nd
sha1sum (hex)	53bc674e5723dc742dbdad40c2ceb0a31a4d62e6
schema:url	https://doi.org/10.1097/cm9.0000000000000824
resource representing a document's title	Clinical characteristics of fatal and recovered cases of coronavirus disease 2019 in Wuhan, China: a retrospective study
has PubMed Central identifier	PMC7289311
has PubMed identifier	32209890
schema:publication	Chin Med J (Engl)
resource representing a document's body	covid:53bc674e5723dc742dbdad40c2ceb0a31a4d62e6#body_text
is schema:about of	named entity 'patients' named entity 'Patients' named entity '[62' named entity 'group' named entity 'dyspnea' named entity 'COVID-19' named entity 'group' named entity 'Wuhan' named entity 'respiratory disease' named entity 'fatal' named entity 'test' named entity '2019' named entity 'group' named entity 'COVID-19' named entity 'Our' named entity 'variables' named entity 'Wuhan' named entity 'hospitalization' named entity 'Methods' named entity 'recovered' named entity 'recovered' named entity 'WBC' named entity 'clinical characteristics' named entity 'lymphocyte' named entity 'expectoration' named entity 'clinical characteristics' named entity 'respiratory disease' named entity 'aspartate transaminase' named entity 'Wuhan' named entity 'Wuhan' named entity 'Clinical characteristics' named entity 'Mann-Whitney U test' named entity 'COVID-19' named entity 'SARS' named entity 'pulmonary fibrosis' named entity 'critically ill patients' named entity 'hepatic' named entity 'antibiotics' named entity 'respiratory rate' named entity 'Tongji Medical College' named entity 'treatment regimens' named entity 'comorbidity' named entity 'mortality rate' named entity 'blood oxygen saturation' named entity 'blood cell count' named entity 'AST' named entity 'coronaviruses' named entity 'corticosteroids' named entity 'drug treatment' named entity 'corticosteroid therapy' named entity 'cardiovascular diseases' named entity 'ARDS' named entity 'blood oxygen saturation' named entity 'pulmonary fibrosis' named entity 'SARS' named entity 'protein' named entity 'Chinese Medical Journal' named entity '2019-nCoV' named entity 'anti-viral drugs' named entity 'Laboratory tests' named entity 'SPSS' named entity 'creatinine' named entity 'pulmonary diseases' named entity 'Wuhan' named entity '2019-nCoV' named entity 'ARDS' named entity 'expectoration' named entity 'medical care' named entity 'lymphocyte'

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