About: Presentation and outcome of Middle East respiratory syndrome in Saudi intensive care unit patients

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About: Presentation and outcome of Middle East respiratory syndrome in Saudi intensive care unit patients Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Presentation and outcome of Middle East respiratory syndrome in Saudi intensive care unit patients
Creator	Mandourah, Yasser Abudayah, Abdullah Aldaghestani, Tareef Alghamedi, Adnan Alwan, Abid Hassan, Sahar Mustafa, Mohamed Sakr, Yasser Talag, Ali Omrani, Ali Albarrak, Mohammed Almekhlafi, Ghaleb Malik, Muhammad
Source	Medline; PMC
abstract	BACKGROUND: Middle East respiratory syndrome coronavirus infection is associated with high mortality rates but limited clinical data have been reported. We describe the clinical features and outcomes of patients admitted to an intensive care unit (ICU) with Middle East respiratory syndrome coronavirus (MERS-CoV) infection. METHODS: Retrospective analysis of data from all adult (>18 years old) patients admitted to our 20-bed mixed ICU with Middle East respiratory syndrome coronavirus infection between October 1, 2012 and May 31, 2014. Diagnosis was confirmed in all patients using real-time reverse transcription polymerase chain reaction on respiratory samples. RESULTS: During the observation period, 31 patients were admitted with MERS-CoV infection (mean age 59 ± 20 years, 22 [71 %] males). Cough and tachypnea were reported in all patients; 22 (77.4 %) patients had bilateral pulmonary infiltrates. Invasive mechanical ventilation was applied in 27 (87.1 %) and vasopressor therapy in 25 (80.6 %) patients during the intensive care unit stay. Twenty-three (74.2 %) patients died in the ICU. Nonsurvivors were older, had greater APACHE II and SOFA scores on admission, and were more likely to have received invasive mechanical ventilation and vasopressor therapy. After adjustment for the severity of illness and the degree of organ dysfunction, the need for vasopressors was an independent risk factor for death in the ICU (odds ratio = 18.33, 95 % confidence interval: 1.11–302.1, P = 0.04). CONCLUSIONS: MERS-CoV infection requiring admission to the ICU is associated with high morbidity and mortality. The need for vasopressor therapy is the main risk factor for death in these patients. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (doi:10.1186/s13054-016-1303-8) contains supplementary material, which is available to authorized users.
has issue date	2016-05-07(xsd:dateTime)
bibo:doi	10.1186/s13054-016-1303-8
bibo:pmid	27153800
has license	cc-by
sha1sum (hex)	53d4dd6acd3501c47b364dbae1ba3dd2083b895a
schema:url	https://doi.org/10.1186/s13054-016-1303-8
resource representing a document's title	Presentation and outcome of Middle East respiratory syndrome in Saudi intensive care unit patients
has PubMed Central identifier	PMC4859954
has PubMed identifier	27153800
schema:publication	Crit Care
resource representing a document's body	covid:53d4dd6acd3501c47b364dbae1ba3dd2083b895a#body_text
is schema:about of	named entity 'data' named entity 'tachypnea' named entity 'infection' named entity 'real-time' named entity 'After' named entity 'ICU' named entity 'samples' named entity 'Middle East respiratory syndrome' named entity 'Invasive' named entity 'OUTCOME' named entity 'USING' named entity 'RATIO' named entity 'CONFIRMED' named entity 'SCORES' named entity 'BILATERAL PULMONARY INFILTRATES' named entity '2880' named entity 'PATIENTS' named entity 'INTENSIVE CARE UNIT' named entity 'OUR' named entity 'RESPIRATORY SAMPLES' named entity 'VASOPRESSOR' named entity 'THESE' named entity 'APPLIED' named entity 'ADJUSTMENT' named entity 'MIXED' named entity 'SOFA' named entity 'DATA' named entity 'TACHYPNEA' named entity 'ASSOCIATED WITH' named entity 'DEGREE' named entity 'ADULT' named entity 'MIDDLE EAST RESPIRATORY SYNDROME CORONAVIRUS' named entity 'BACKGROUND' named entity 'APACHE II' named entity 'RISK FACTOR' named entity 'LIMITED' named entity 'DIAGNOSIS' named entity 'THERAPY' named entity 'TWENTY-THREE' named entity 'CONCLUSIONS' named entity 'OCTOBER' named entity 'MORBIDITY AND MORTALITY' named entity 'HIGH' named entity 'OLD' named entity '0.04' named entity 'REPORTED' named entity 'OBSERVATION' named entity 'NEED FOR' named entity 'INFECTION' named entity 'ICU' named entity 'CLINICAL FEATURES' named entity 'AGE' named entity 'INTENSIVE CARE UNIT STAY' named entity 'BUT' named entity 'OUTCOMES' named entity 'ADMISSION' named entity 'SAUDI' named entity 'INTENSIVE CARE UNIT' named entity 'PRESENTATION' named entity 'PATIENTS' named entity 'MIDDLE EAST RESPIRATORY SYNDROME ' named entity 'REAL-TIME REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION' named entity 'COUGH' named entity 'VASOPRESSORS' named entity 'RETROSPECTIVE ANALYSIS' named entity '2887' named entity 'DEATH' named entity 'METHODS' named entity 'GREATER'

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