About: Identification of Mouse Hepatitis Coronavirus A59 Nucleocapsid Protein Phosphorylation Sites

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An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Identification of Mouse Hepatitis Coronavirus A59 Nucleocapsid Protein Phosphorylation Sites
Creator	Hogue, Brenda Yi, Zhengping White, Tiana
Source	Elsevier; Medline; PMC
abstract	The coronavirus nucleocapsid (N) is a multifunctional phosphoprotein that encapsidates the genomic RNA into a helical nucleocapsid within the mature virion. The protein also plays roles in viral RNA transcription and/or replication and possibly viral mRNA translation. Phosphorylation is one of the most common post-translation modifications that plays important regulatory roles in modulating protein functions. It has been speculated for sometime that phosphorylation could play an important role in regulation of coronavirus N protein functions. As a first step toward positioning to address this we have identified the amino acids that are phosphorylated on the mouse hepatitis coronavirus (MHV) A59 N protein. High performance liquid chromatography coupled with electrospray ionization tandem mass spectrometry (HPLC-ESI-MS/MS) was used to identify phosphorylated sites on the N protein from both infected cells and purified extracellular virions. A total of six phosphorylated sites (S162, S170, T177, S389, S424 and T428) were identified on the protein from infected cells. The same six sites were also phosphorylated on the extracellular mature virion N protein. This is the first identification of phosphorylated sites for a group II coronavirus N protein.
has issue date	2007-06-01(xsd:dateTime)
bibo:doi	10.1016/j.virusres.2007.02.008
bibo:pmid	17367888
has license	bronze-oa
sha1sum (hex)	5411f11bad3be63f36da71eeb6e16b09140ce199
schema:url	https://doi.org/10.1016/j.virusres.2007.02.008
resource representing a document's title	Identification of Mouse Hepatitis Coronavirus A59 Nucleocapsid Protein Phosphorylation Sites
has PubMed Central identifier	PMC2001268
has PubMed identifier	17367888
schema:publication	Virus Research
resource representing a document's body	covid:5411f11bad3be63f36da71eeb6e16b09140ce199#body_text
is schema:about of	named entity 'Phosphorylation' named entity 'High performance liquid chromatography' named entity 'coronavirus' named entity 'NUCLEOCAPSID PROTEIN' named entity 'PHOSPHOPROTEIN' named entity 'SITES' named entity 'COUPLED' named entity 'MOUSE HEPATITIS' named entity 'PLAY' named entity 'A59' named entity 'MODULATING' named entity 'LIQUID CHROMATOGRAPHY ' named entity 'GROUP II' named entity 'TRANSCRIPTION' named entity 'FUNCTIONS' named entity 'CELLS' named entity 'HIGH PERFORMANCE LIQUID CHROMATOGRAPHY' named entity 'REGULATION' named entity 'A59' named entity 'IDENTIFICATION' named entity 'ESI-MS' named entity 'REGULATORY' named entity 'CORONAVIRUS' named entity 'PHOSPHORYLATION SITES' named entity 'INFECTED' named entity 'POST-TRANSLATION MODIFICATIONS' named entity 'A GROUP' named entity 'COMMON' named entity 'FIRST STEP' named entity 'AMINO ACIDS' named entity 'ADDRESS' named entity 'VIRAL RNA' named entity 'POSITIONING' named entity 'VIRAL MRNA TRANSLATION' named entity 'CORONAVIRUS' named entity 'USED' named entity 'PLAYS' named entity 'ROLES' named entity 'ELECTROSPRAY IONIZATION' named entity 'VIRION' named entity 'EXTRACELLULAR' named entity 'N PROTEIN' named entity 'IDENTIFIED' named entity 'REPLICATION' named entity 'MOUSE HEPATITIS' named entity 'TO IDENTIFY' named entity 'IMPORTANT' named entity 'MATURE' named entity 'TANDEM MASS SPECTROMETRY' named entity 'TOTAL' named entity 'PROTEIN ' named entity 'HAVE' named entity 'PURIFIED' named entity 'HELICAL' named entity 'ROLE' named entity 'VIRIONS' named entity 'RNA' named entity 'PHOSPHORYLATION' named entity 'NUCLEOCAPSID' named entity 'GENOMIC' named entity 'IDENTIFICATION' named entity 'PHOSPHORYLATED' named entity 'PROTEIN PHOSPHORYLATION' named entity 'IS A' named entity 'ONE OF' named entity 'POSSIBLY' named entity 'speculated' named entity 'modulating' named entity 'identified' named entity 'viral' named entity 'virion' named entity 'protein' named entity 'phosphorylated' named entity 'replication' named entity 'protein' named entity 'identify' named entity 'phosphorylated' named entity 'phosphoprotein' named entity 'nucleocapsid'

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