About: Generation of inner ear hair cells by direct lineage conversion of primary somatic cells

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An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
title	Generation of inner ear hair cells by direct lineage conversion of primary somatic cells
Creator	Lee, James Gopalakrishnan, Suhasni Huang, Chichou Ichida, Justin Kalluri, Radha Llamas, Juan Markowitz, Alexander Menendez, Louise Segil, Neil Tao, Litao Trecek, Talon Wang, Xizi Yu, Haoze
source	PMC
abstract	The mechanoreceptive sensory hair cells in the inner ear are selectively vulnerable to numerous genetic and environmental insults. In mammals, hair cells lack regenerative capacity, and their death leads to permanent hearing loss and vestibular dysfunction. Their paucity and inaccessibility has limited the search for otoprotective and regenerative strategies. Growing hair cells in vitro would provide a route to overcome this experimental bottleneck. We report a combination of four transcription factors (Six1, Atoh1, Pou4f3, and Gfi1) that can convert mouse embryonic fibroblasts, adult tail-tip fibroblasts and postnatal supporting cells into induced hair cell-like cells (iHCs). iHCs exhibit hair cell-like morphology, transcriptomic and epigenetic profiles, electrophysiological properties, mechanosensory channel expression, and vulnerability to ototoxin in a high-content phenotypic screening system. Thus, direct reprogramming provides a platform to identify causes and treatments for hair cell loss, and may help identify future gene therapy approaches for restoring hearing.
has issue date	2020-06-30(xsd:dateTime)
bibo:doi	10.7554/elife.55249
bibo:pmid	32602462
has license	cc-by
sha1sum (hex)	5418783a26f473cec99e73bb7adb2e7ec375c794
schema:url	https://doi.org/10.7554/elife.55249
resource representing a document's title	Generation of inner ear hair cells by direct lineage conversion of primary somatic cells
has PubMed Central identifier	PMC7326493
has PubMed identifier	32602462
resource representing a document's body	covid:5418783a26f473cec99e73bb7adb2e7ec375c794#body_text
is schema:about of	named entity 'permanent' named entity 'hair cells' named entity 'vestibular' named entity 'transcriptomic' named entity 'somatic cells' named entity 'MECHANOSENSORY' named entity 'APPROACHES' named entity 'VULNERABILITY' named entity 'TREATMENTS' named entity 'MAMMALS' named entity 'PLATFORM' named entity 'convert' named entity 'ear' named entity 'vulnerability' named entity 'hair' named entity 'fibroblasts' named entity 'capacity' named entity 'Thus' named entity 'hair cells' named entity 'Gfi1' named entity 'expression' named entity 'loss' named entity 'restoring' named entity 'regenerative' named entity 'postnatal' named entity 'hearing loss' named entity 'phenotypic screening' named entity 'Generation' named entity 'Pou4f3' named entity 'Sigma-Aldrich' named entity 'transdifferentiation' named entity 'Atoh1' named entity 'Whrn' named entity 'hair cells' named entity 'hearing loss' named entity 'GTTR' named entity 'hair cells' named entity 'Gene ontology' named entity 'gentamicin' named entity 'Gene Ontology' named entity 'Parvalbumin' named entity 'degrees Celsius' named entity 'Pou4f3' named entity 'hair cell' named entity 'environmental stress' named entity 'eLife' named entity 'enhancer' named entity 'gene' named entity 'hair cells' named entity 'Wild type' named entity 'transduced' named entity 'downregulated' named entity 'enhancers' named entity 'Atoh1' named entity 'hair cell' named entity 'hair cells' named entity 'HCs' named entity 'ATAC' named entity 'hair cell' named entity 'one-way ANOVA' named entity 'Texas Red' named entity 'FACS' named entity 'GSEA' named entity 'Atoh1' named entity 'autosomal chromosomes' named entity 'protein coding' named entity 'Rhodamine' named entity 'tissue culture' named entity 'single cell' named entity 'Dallos'

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