About: Antiviral activity of carbohydrate-binding agents against Nidovirales in cell culture

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About: Antiviral activity of carbohydrate-binding agents against Nidovirales in cell culture Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

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type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Antiviral activity of carbohydrate-binding agents against Nidovirales in cell culture
Creator	Balzarini, J De Haan, C Egberink, H Delputte, P Haijema, B Peumans, W Schuurman, N Van Damme, E Van Der Meer, F
Source	Elsevier; Medline; PMC
abstract	Abstract Coronaviruses are important human and animal pathogens, the relevance of which increased due to the emergence of new human coronaviruses like SARS-CoV, HKU1 and NL63. Together with toroviruses, arteriviruses, and roniviruses the coronaviruses belong to the order Nidovirales. So far antivirals are hardly available to combat infections with viruses of this order. Therefore, various antiviral strategies to counter nidoviral infections are under evaluation. Lectins, which bind to N-linked oligosaccharide elements of enveloped viruses, can be considered as a conceptionally new class of virus inhibitors. These agents were recently evaluated for their antiviral activity towards a variety of enveloped viruses and were shown in most cases to inhibit virus infection at low concentrations. However, limited knowledge is available for their efficacy towards nidoviruses. In this article the application of the plant lectins Hippeastrum hybrid agglutinin (HHA), Galanthus nivalis agglutinin (GNA), Cymbidium sp. agglutinin (CA) and Urtica dioica agglutinin (UDA) as well as non-plant derived pradimicin-A (PRM-A) and cyanovirin-N (CV-N) as potential antiviral agents was evaluated. Three antiviral tests were compared based on different evaluation principles: cell viability (MTT-based colorimetric assay), number of infected cells (immunoperoxidase assay) and amount of viral protein expression (luciferase-based assay). The presence of carbohydrate-binding agents strongly inhibited coronaviruses (transmissible gastroenteritis virus, infectious bronchitis virus, feline coronaviruses serotypes I and II, mouse hepatitis virus), arteriviruses (equine arteritis virus and porcine respiratory and reproductive syndrome virus) and torovirus (equine Berne virus). Remarkably, serotype II feline coronaviruses and arteriviruses were not inhibited by PRM-A, in contrast to the other viruses tested.
has issue date	2007-10-31(xsd:dateTime)
bibo:doi	10.1016/j.antiviral.2007.04.003
bibo:pmid	17560666
has license	els-covid
sha1sum (hex)	54440a66bfd06044fbfdf583650fbc4cebf21241
schema:url	https://doi.org/10.1016/j.antiviral.2007.04.003
resource representing a document's title	Antiviral activity of carbohydrate-binding agents against Nidovirales in cell culture
has PubMed Central identifier	PMC7132385
has PubMed identifier	17560666
schema:publication	Antiviral Research
resource representing a document's body	covid:54440a66bfd06044fbfdf583650fbc4cebf21241#body_text
is schema:about of	named entity 'virus' named entity 'feline' named entity 'pathogens' named entity 'evaluation' named entity 'inhibited' named entity 'agglutinin' named entity 'regarded' named entity 'linear' named entity 'viability' named entity 'Galanthus nivalis' named entity 'envelopes' named entity 'drugs' named entity 'application' named entity 'cell culture' named entity 'EVALUATION' named entity 'DRUGS' named entity 'DIFFERENT' named entity 'POTENTIAL' named entity 'LECTINS' named entity 'BINDING' named entity 'MEMBER OF' named entity 'RELEVANCE' named entity 'GASTROENTERITIS' named entity 'HAVE' named entity 'SPECIFIC' named entity 'CYANOVIRIN-N' named entity 'GALANTHUS NIVALIS' named entity 'CARBOHYDRATE' named entity 'COMPARED' named entity 'SEROTYPES' named entity 'IMPORTANT' named entity 'VARIOUS' named entity 'HYBRID' named entity 'PLANT' named entity 'NIDOVIRALES' named entity 'INFECTED' named entity 'PROTECTION' named entity 'ELEMENTS' named entity 'ORDER' named entity 'CLASS' named entity 'NIDOVIRALES' named entity 'CELL CULTURE' named entity 'BINDING' named entity 'ANTIVIRAL ACTIVITY' named entity 'COUNTER' named entity 'PRADIMICIN' named entity 'DUE TO' named entity 'OLIGOSACCHARIDE' named entity 'NUMBER OF' named entity 'INCREASED' named entity 'THEIR' named entity 'TO INHIBIT' named entity 'LIKE' named entity 'EFFICACY' named entity 'VACCINES' named entity 'CELL VIABILITY' named entity 'STRATEGIES' named entity 'PROTEIN EXPRESSION' named entity 'ANTIVIRALS' named entity 'ANTIVIRAL AGENTS' named entity 'INFECTIOUS BRONCHITIS VIRUS' named entity 'RELIANCE' named entity 'GROUP' named entity 'VIRAL PROTEIN' named entity 'LIMITED' named entity 'VIRUS' named entity 'ARTICLE' named entity 'POSSIBLE' named entity 'THESE' named entity 'HARDLY' named entity 'NON-' named entity 'CARBOHYDRATE' named entity 'SARS-COV'

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