About: PA-X-associated early alleviation of the acute lung injury contributes to the attenuation of a highly pathogenic H5N1 avian influenza virus in mice

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About: PA-X-associated early alleviation of the acute lung injury contributes to the attenuation of a highly pathogenic H5N1 avian influenza virus in mice Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
title	PA-X-associated early alleviation of the acute lung injury contributes to the attenuation of a highly pathogenic H5N1 avian influenza virus in mice
Creator	Liu, Xiufan Chen, Sujuan Gu, Min Hu, Jiao Hu, Shunlin Liu, Huimou Liu, Wenbo Wang, Xiaoquan Liu, · Cheng, Xin Gao, Zhao Liang, Yanyan Mo, Yiqun Peng, Daxing
source	Medline; PMC
abstract	PA-X is a novel discovered accessory protein encoded by the PA mRNA. Our previous study demonstrated that PA-X decreases the virulence of a highly pathogenic H5N1 strain A/Chicken/Jiangsu/k0402/2010 in mice. However, the underlying mechanism of virulence attenuation associated with PA-X is still unknown. In this study, we compared two PA-X-deficient mutant viruses and the parental virus in terms of induction of pathology and manipulation of host response in the mouse lung, stimulation of cell death and PA nuclear accumulation. We first found that down-regulated PA-X expression markedly aggravated the acute lung injury of the infected mice early on day 1 post-infection (p.i.). We then determined that loss of PA-X expression induced higher levels of cytokines, chemokines and complement-derived peptides (C3a and C5a) in the lung, especially at early time point’s p.i. In addition, in vitro assays showed that the PA-X-deficient viruses enhanced cell death and increased expression of reactive oxygen species (ROS) in mammalian cells. Moreover, we also found that PA nuclear accumulation of the PA-X-null viruses accelerated in MDCK cells. These results demonstrate that PA-X decreases the level of complement components, ROS, cell death and inflammatory response, which may together contribute to the alleviated lung injury and the attenuation of the virulence of H5N1 virus in mice.
has issue date	2016-06-11(xsd:dateTime)
bibo:doi	10.1007/s00430-016-0461-2
bibo:pmid	27289459
has license	no-cc
sha1sum (hex)	5449838ef0bf7f54cd73511546132a1c6c275f5e
schema:url	https://doi.org/10.1007/s00430-016-0461-2
resource representing a document's title	PA-X-associated early alleviation of the acute lung injury contributes to the attenuation of a highly pathogenic H5N1 avian influenza virus in mice
has PubMed Central identifier	PMC7086737
has PubMed identifier	27289459
schema:publication	Med Microbiol Immunol
resource representing a document's body	covid:5449838ef0bf7f54cd73511546132a1c6c275f5e#body_text
is schema:about of	named entity 'virus' named entity 'attenuation' named entity 'avian influenza' named entity 'MICE' named entity 'ATTENUATION' named entity 'VIRULENCE' covid:arg/5449838ef0bf7f54cd73511546132a1c6c275f5e named entity 'EARLY' named entity 'AVIAN INFLUENZA VIRUS' named entity 'H5N1' named entity 'CONTRIBUTE ' named entity 'HIGHLY' named entity 'PATHOGENIC' named entity 'ATTENUATION' named entity 'PA-X' named entity 'MICE' named entity 'ASSOCIATED' named entity 'ACUTE LUNG INJURY' named entity 'LUNG INJURY' named entity 'H5N1 VIRUS' named entity 'mice' named entity 'mice' named entity 'virus' named entity 'acute lung injury' named entity 'cell death' named entity 'Viral replication' named entity 'MDCK' named entity 'cell apoptosis' named entity 'formalin' named entity '2009 H1N1' named entity 'ARDS' named entity 'influenza virus' named entity 'IFN-γ' named entity 'virus' named entity 'Jiangsu' named entity '0.01' named entity 'C5a' named entity 'genetic variability' named entity 'CCL3' named entity 'C3a' named entity 'influenza virus' named entity 'cell death' named entity 'virus' named entity 'innate immunity' named entity 'mice' named entity 'cytokines' named entity 'C5a' named entity 'H5N1' named entity 'ROS' named entity 'MDCK' named entity 'nuclear localization' named entity 'viral titers' named entity 'ROS' named entity 'pathogenesis' named entity 'virus' named entity 'PBS' named entity 'necrosis' named entity 'host cell' named entity 'viral replication' named entity 'polymerase' named entity 'complement' named entity 'chemokines' named entity 'protein' named entity 'PBS' named entity 'viral replication' named entity 'H&E' named entity 'A549' named entity 'host response'

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