About: The peripheral blood immune cell profile in a teriflunomide-treated multiple sclerosis patient with COVID-19 pneumonia

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About: The peripheral blood immune cell profile in a teriflunomide-treated multiple sclerosis patient with COVID-19 pneumonia Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
title	The peripheral blood immune cell profile in a teriflunomide-treated multiple sclerosis patient with COVID-19 pneumonia
Creator	Ciardi, Maria Conte, Antonella Mastroianni, Claudio Pasculli, Patrizia Perri, Valentina Russo, Gianluca Tartaglia, Matteo Valeri, Serena Zingaropoli, Maria
source	Elsevier; Medline; PMC
abstract	A teriflunomide-treated multiple sclerosis patient with COVID-19 pneumonia was hospitalized and recovered in 15 days. The immunophenotyping analysis of peripheral blood cells was performed in two time points: the first was 1 month before (pre-infection) while the second was during COVID-19 pneumonia (infection). At the infection time point, no differences in the percentages of immune activation and immunesenescence of CD4+ and CD8+ T-cells were observed compared to the pre-infection time point. Our evaluation seems to confirm that teriflunomide control T-cells immune activation and immunosenescence suggesting that teriflunomide should not be discontinued in MS patients with an active COVID-19 pneumonia.
has issue date	2020-07-15(xsd:dateTime)
bibo:doi	10.1016/j.jneuroim.2020.577323
bibo:pmid	32688146
has license	no-cc
sha1sum (hex)	549c8af36570048f2e8b7cffa3e107d58a93147d
schema:url	https://doi.org/10.1016/j.jneuroim.2020.577323
resource representing a document's title	The peripheral blood immune cell profile in a teriflunomide-treated multiple sclerosis patient with COVID-19 pneumonia
has PubMed Central identifier	PMC7361089
has PubMed identifier	32688146
schema:publication	J Neuroimmunol
resource representing a document's body	covid:549c8af36570048f2e8b7cffa3e107d58a93147d#body_text
is schema:about of	named entity 'patient' named entity 'pneumonia' named entity 'performed' named entity 'monocytes' named entity 'teriflunomide' named entity 'immune cell' named entity 'COVID-19' named entity 'total' named entity 'time point' named entity 'time' named entity 'COVID-19' named entity 'Journal' named entity 'control' named entity 'profile' named entity 'discontinued' named entity 'immune' named entity 'profile' named entity 'immune cell' named entity 'peripheral blood' named entity 'CD4+' named entity 'COVID-19' named entity 'COVID-19' named entity 'multiple sclerosis' named entity 'infection' named entity 'NKT' named entity 'peripheral blood' named entity 'M.R.' named entity 'Empiric antibiotic therapy' named entity 'Sapienza University of Rome' named entity 'fever' named entity 'host response' named entity 'partial pressure' named entity 'lymphopenia' named entity 'respiratory syncytial virus' named entity 'protein' named entity 'HLA-DR' named entity 'bronchial wall thickening' named entity 'Hologic' named entity 'plasma levels' named entity 'Clostridium difficile infection' named entity 'viral infections' named entity 'Teriflunomide' named entity 'pneumonia' named entity 'respiratory rate' named entity 'CD16' named entity 'T-cells' named entity 'natural killer (NK) cell' named entity 'pneumonia' named entity 'Merino' named entity 'Tcell' named entity 'Medina' named entity 'down-regulating' named entity 'pneumonia' named entity 'acute respiratory distress syndrome' named entity 'peripheral blood cell' named entity 'teriflunomide' named entity 'teriflunomide' named entity 'immunocompetent individuals' named entity 'COVID-19 outbreak' named entity 'immunomodulatory' named entity 'teriflunomide' named entity 'T-cell' named entity 'risk factors' named entity 'clinical indication' named entity 'monocytes' named entity 'Blood gas analysis' named entity 'COVID' named entity 'viral infection' named entity 'Italian' named entity 'infection' named entity 'T-cells' named entity 'SARS-CoV-2' named entity 'reversibly inhibits'

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