About: Aging increases the systemic molecular degree of inflammatory perturbation in patients with tuberculosis

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About: Aging increases the systemic molecular degree of inflammatory perturbation in patients with tuberculosis Goto Sponge NotDistinct Permalink

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Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Aging increases the systemic molecular degree of inflammatory perturbation in patients with tuberculosis
Creator	Kumar, Pavan Andrade, Bruno Fukutani, Kiyoshi Babu, Subash Arriaga, María Oliveira-De-Souza, Deivide Queiroz, Artur Vinhaes, Caian
Source	Medline; PMC
abstract	Tuberculosis (TB) is a chronic infection that can affect individuals of all ages. The description of determinants of immunopathogenesis in TB is of tremendous interest due to the perspective of finding a reliable host-directed therapy to reduce disease burden. The association between specific biomarker profiles related to inflammation and the diverse clinical disease presentations in TB has been extensively studied in adults. However, relatively scarce data on profiling the inflammatory responses in pediatric TB are available. Here, we employed the molecular degree of perturbation (MDP) score adapted to plasma biomarkers in two distinct databanks from studies that examined either adults or children presenting with pulmonary or extrapulmonary disease. We used multidimensional statistical analyses to characterize the impact of age on the overall changes in the systemic inflammation profiles in subpopulation of TB patients. Our findings indicate that TB results in significant increases in molecular perturbation, with the highest values being detected in adult patients. Furthermore, there were unique differences in the biomarker perturbation patterns and the overall degree of inflammation according to disease site and age. Importantly, the molecular degree of perturbation was not influenced by sex. Our results revealed that aging is an important determinant of the differences in quality and magnitude of systemic inflammatory perturbation in distinct clinical forms of TB.
has issue date	2020-07-09(xsd:dateTime)
bibo:doi	10.1038/s41598-020-68255-0
bibo:pmid	32647178
has license	cc-by
sha1sum (hex)	54a8f6930016177742dccdc4df233d483a7774f0
schema:url	https://doi.org/10.1038/s41598-020-68255-0
resource representing a document's title	Aging increases the systemic molecular degree of inflammatory perturbation in patients with tuberculosis
has PubMed Central identifier	PMC7347549
has PubMed identifier	32647178
schema:publication	Sci Rep
resource representing a document's body	covid:54a8f6930016177742dccdc4df233d483a7774f0#body_text
is schema:about of	named entity 'analyses' named entity 'degree' named entity 'systemic' named entity 'SYSTEMIC INFLAMMATION' named entity 'INFLAMMATORY' named entity 'HIGHEST' named entity 'TO CHARACTERIZE' named entity 'SYSTEMIC' named entity 'OUR' named entity 'PERTURBATION' named entity 'INFLAMMATION' named entity 'inflammatory responses' named entity 'TB.' named entity 'Our' named entity 'inflammation' named entity 'influenced' named entity 'perturbation' named entity 'data' named entity 'disease' named entity 'inflammation' named entity 'IFN-γ' named entity 'ad hoc test' named entity 'vaccination' named entity 'BCG' named entity 'Scientific RepoRtS' named entity 'MMP-8' named entity 'Pearson's chi-square test' named entity 'tuberculosis' named entity 'MMP-8' named entity 'molecular markers' named entity 'pediatric' named entity 'immunological' named entity 'biomarkers' named entity 'extrapulmonary' named entity 'batch effects' named entity 'pathogenesis' named entity 'biomarkers' named entity 'immune response' named entity 'tissue remodeling' named entity 'pediatric' named entity 'plasma' named entity 'tissue remodeling' named entity 'HO-1' named entity 'ComBat' named entity 'peripheral blood' named entity 'critical role' named entity 'TIMP' named entity 'IL-1β' named entity 'innate immune responses' named entity 'pediatric' named entity 'intracellular pathogens' named entity 'infection' named entity 'z-score' named entity 'TIMP' named entity 'pandemics' named entity 'force-directed graph drawing' named entity 'clinical investigations' named entity 'IFN' named entity 'statistically significant' named entity 'systemic inflammatory response' named entity 'vascular endothelial growth factor' named entity 'MMP-8' named entity 'IL-1β' named entity 'cytokines' named entity 'Spearman correlation' named entity 'BCG' named entity 'TIMP-1' named entity 'HO-1' named entity 'India' named entity 'IL-1β' named entity 'HO-1' named entity 'inversely correlated' named entity 'biomarker' named entity 'pathogenesis'

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