About: Anticancer Activity of Tetrandrine by Inducing Apoptosis in Human Breast Cancer Cell Line MDA-MB-231 In Vivo

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An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

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type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
title	Anticancer Activity of Tetrandrine by Inducing Apoptosis in Human Breast Cancer Cell Line MDA-MB-231 In Vivo
Creator	Guo, Yu-Bo Pei, Xiao-Hua Shen, Jing Wang, Chun-Hui Yang, Jia-Min
source	PMC
abstract	Tetrandrine (TET) is an alkaloid extracted from a traditional Chinese medicinal plant. It exerts remarkable anticancer activity and induces apoptotic cell death in various human cancer cells. The present study aimed to investigate the effects of TET on the inhibition of tumor growth and the induction of apoptosis in MDA-MB-231 breast cancer in xenograft mice. Tumor weight and volume were measured. The histopathological changes in the tumor tissue were observed. Immunohistochemistry analysis of Bcl-2-associated X protein (Bax) and B-cell lymphoma/leukemia-2 (Bcl-2) was carried out. The expression of apoptosis-associated genes and proteins, such as cysteine aspartic acid-specific protease-3 (Caspase-3), Survivin, Bax, Bcl-2, BH3-interacting domain death agonist (Bid), and poly ADP-ribose polymerase (PARP), was measured by reverse transcription-polymerase chain reaction (RT-PCR) and Western blotting, respectively. TET inhibited tumor growth and induced apoptosis in TNBC cell line MDA-MB-231. The mechanism underlying this effect might be mediated by TET-upregulated Caspase-3, Bax, and Bid and downregulated by Bcl-2, Survivin, and PARP. Taken together, this study supported the fact that TET is a promising therapeutic agent for the treatment of TNBC, thereby providing experimental evidence for its use in the treatment of breast cancer.
has issue date	2020-06-30(xsd:dateTime)
bibo:doi	10.1155/2020/6823520
bibo:pmid	32714412
has license	cc-by
sha1sum (hex)	54f41a7bafd860797a48cbb9c148d94ca63449e8
schema:url	https://doi.org/10.1155/2020/6823520
resource representing a document's title	Anticancer Activity of Tetrandrine by Inducing Apoptosis in Human Breast Cancer Cell Line MDA-MB-231 In Vivo
has PubMed Central identifier	PMC7345956
has PubMed identifier	32714412
schema:publication	Evid Based Complement Alternat Med
resource representing a document's body	covid:54f41a7bafd860797a48cbb9c148d94ca63449e8#body_text
is schema:about of	named entity 'RT-PCR' named entity 'BH3' named entity 'apoptosis' named entity 'aspartic acid' named entity 'traditional Chinese medicinal' named entity 'xenograft' named entity 'Bcl-2-associated X protein' named entity 'Immunohistochemistry' named entity 'Bax' named entity 'TNBC' named entity 'Tumor' named entity 'PARP' named entity 'alkaloid' named entity 'Survivin' named entity 'poly ADP-ribose polymerase' named entity 'agonist' named entity 'Bax' named entity 'breast cancer' named entity 'tumor growth' named entity 'tumor' named entity 'Tetrandrine' named entity 'Bcl-2-associated X protein' named entity 'serum' named entity 'pentobarbital sodium' named entity 'HER2' named entity 'HER2' named entity 'TNBC' named entity 'Caspase-3' named entity 'cell death' named entity 'Tumors' named entity 'calcium' named entity 'China' named entity 'Horseradish peroxidase' named entity 'breast cancer' named entity 'apoptosis' named entity 'mitochondrial' named entity 'nude mouse' named entity 'β-actin' named entity 'Millipore' named entity 'Caspase-3' named entity 'hematoxylin and eosin' named entity 'hormone' named entity 'molecular signaling' named entity 'PBS' named entity 'transcriptional regulation' named entity 'obese' named entity 'basal cell' named entity 'PVDF' named entity 'denaturation' named entity 'protein' named entity 'Promega' named entity 'hematoxylin' named entity 'tumors' named entity 'reverse transcription-polymerase chain reaction' named entity 'Complementary and Alternative Medicine' named entity 'cytoplasmic' named entity 'apoptotic' named entity 'Bcl-2' named entity 'breast cancer' named entity 'inflammatory cell' named entity 'China' named entity 'antiapoptotic' named entity 'death rate' named entity 'ANOVA' named entity 'stress conditions' named entity 'TNBC' named entity 'human epidermal growth factor receptor-2' named entity 'immunohistochemistry' named entity 'hypertension' named entity 'tumor' named entity 'DAB' named entity 'weight loss' named entity 'Stephania tetrandra' named entity 'Survivin' named entity 'tumorigenesis' named entity 'downregulation' named entity 'targeted treatment'

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