About: Potenciales biomarcadores predictores de mortalidad en pacientes COVID-19 en el Servicio de Urgencias

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An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
title	Potenciales biomarcadores predictores de mortalidad en pacientes COVID-19 en el Servicio de Urgencias
Creator	Española De Quimioterapia, Revista Cremades, Inmaculada Lobo, Iván Pascual Gómez, Natalia Rueda, Fernando Tejerina, Angels Campos, Arrabal Manuel, Francisco Teleki, Wernitz Von, Andrés
source	Medline; PMC
abstract	OBJECTIVE: Identify which biomarkers performed in the first emergency analysis help to stratify COVID-19 patients according to mortality risk. METHOD: Observational, descriptive and cross-sectional study performed with data collected from patients with suspected COVID-19 in the Emergency Department from February 24 to March 16, 2020. The univariate and multivariate study was performed to find independent mortality markers and calculate risk by building a severity score. RESULTS: A total of 163 patients were included, of whom 33 died and 29 of them were positive for the COVID-19 PCR test. We obtained as possible factors to conform the Mortality Risk Score age> 75 years ((adjusted OR = 12,347, 95% CI: 4,138-36,845 p = 0.001), total leukocytes> 11,000 cells / mm(3) (adjusted OR = 2,649, 95% CI: 0.879-7.981 p = 0.083), glucose> 126 mg / dL (adjusted OR = 3.716, 95% CI: 1.24711.074 p = 0.018) and creatinine> 1.1 mg / dL (adjusted OR = 2.566, 95% CI: 0.8897.403, p = 0.081) This score was called COVEB (COVID, Age, Basic analytical profile) with an AUC 0.874 (95% CI: 0.816-0.933, p <0.001; Cut-off point = 1 (sensitivity = 89.66 % (95% CI: 72.6% -97.8%), specificity = 75.59% (95% CI: 67.2% -82.8%). A score <1 has a negative predictive value = 100% (95% CI: 93.51% -100%) and a positive predictive value = 18.59% (95% CI: 12.82% -25.59%). CONCLUSIONS: . Clinical severity scales, kidney function biomarkers, white blood cell count parameters, the total neutrophils / total lymphocytes ratio and procalcitonin are early risk factors for mortality. The variables age, glucose, creatinine and total leukocytes stand out as the best predictors of mortality. A COVEB score <1 indicates with a 100% probability that the patient with suspected COVID-19 will not die in the next 30 days.
has issue date	2020-07-13(xsd:dateTime)
bibo:doi	10.37201/req/060.2020
bibo:pmid	32657550
has license	cc-by-nc
sha1sum (hex)	5531a4383ead6434f7e5230bec6c7865e6c1ab9d
schema:url	https://doi.org/10.37201/req/060.2020
resource representing a document's title	Potenciales biomarcadores predictores de mortalidad en pacientes COVID-19 en el Servicio de Urgencias
has PubMed Central identifier	PMC7374038
has PubMed identifier	32657550
schema:publication	Rev Esp Quimioter
resource representing a document's body	covid:5531a4383ead6434f7e5230bec6c7865e6c1ab9d#body_text
is schema:about of	named entity 'https' named entity '100%' named entity 'clave' named entity 'COVID-19' named entity 'Attribution-NonCommercial' named entity 'COVID-19' named entity 'Comunidad de Madrid' named entity 'Community-Acquired Pneumonia' named entity 'infección' named entity 'Pneumonia Severity Index' named entity 'diabetes mellitus' named entity 'SARS-CoV-2' named entity 'GGT' named entity 'procalcitonin' named entity 'PSI' named entity 'independiente' named entity 'PCR' named entity 'kidney function' named entity 'esta' named entity 'COVID-19' named entity 'infección' named entity 'SARS-CoV-2' named entity 'la toma' named entity 'infección' named entity 'UCI' named entity 'IL6' named entity 'infección' named entity 'PCR' named entity 'white blood cell' named entity 'ido' named entity 'leukocytes' named entity 'SARS-CoV-2' named entity 'tabla' named entity 'urea' named entity 'SARS-CoV-2' named entity 'COVID-19' named entity 'UCI' named entity 'urea' named entity 'SARS-CoV-2' named entity 'infección' named entity 'urea' named entity 'infección' named entity 'neutrophils' named entity 'glucose' named entity 'diabetes mellitus' named entity 'creatinine' named entity 'igual' named entity 'SARS-COV-2' named entity 'infección' named entity 'rRT-PCR' named entity 'Hospital Universitario de la Princesa' named entity 'decisiones' named entity 'COVID-19' named entity 'la toma' named entity 'tabla' named entity 'PCR' named entity 'COVID-19' named entity 'la alteración' named entity 'puede ser' named entity 'fallo' named entity 'PSI' named entity 'SARS-CoV-2' named entity 'COVID' named entity 'CC BY-NC' named entity 'Creative Commons' named entity 'score' named entity 'COVID' named entity 'QUE' named entity 'SARS-COV-2' named entity 'LOS' named entity 'PACIENTE' named entity 'CREATININA'

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