About: Construction of recombinant Lactobacillus casei efficiently surface displayed and secreted porcine parvovirus VP2 protein and comparison of the immune responses induced by oral immunization

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About: Construction of recombinant Lactobacillus casei efficiently surface displayed and secreted porcine parvovirus VP2 protein and comparison of the immune responses induced by oral immunization Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Construction of recombinant Lactobacillus casei efficiently surface displayed and secreted porcine parvovirus VP2 protein and comparison of the immune responses induced by oral immunization
Source	Medline; PMC
abstract	Lactobacillus casei ATCC 393 was selected as a bacterial carrier for the development of mucosal vaccine against porcine parvovirus (PPV) infection. The PPV major structural polypeptide VP2 was used as the model parvovirus antigen. Two inducible expression systems, namely pPG611.1 of the cell-surface expression system and pPG612.1 of the secretion expression system based on the xylose operon promoter were used to express the VP2 protein. The immunogenicity of recombinant strains producing VP2 protein in two cellular locations, cell-surface exposed and secreted, was compared to each other by immunizing mice through the intragastric administration. The two types of constructs were able to induce strong specific immune responses against VP2 via intragastric administration and maximum titres of IgA and IgG were attained on days 46 post oral immunization, while the highest antibody levels were obtained with the strain producing the VP2 protein in extracellular milieu. The induced antibodies demonstrated neutralizing effects on PPV infection.
has issue date	2008-05-01(xsd:dateTime)
bibo:doi	10.1111/j.1365-2567.2007.02738.x
bibo:pmid	18034821
has license	green-oa
sha1sum (hex)	553687d7921024d6b5c96f808e01c77fa9537ab4
schema:url	https://doi.org/10.1111/j.1365-2567.2007.02738.x
resource representing a document's title	Construction of recombinant Lactobacillus casei efficiently surface displayed and secreted porcine parvovirus VP2 protein and comparison of the immune responses induced by oral immunization
has PubMed Central identifier	PMC2434381
has PubMed identifier	18034821
schema:publication	Immunology
resource representing a document's body	covid:553687d7921024d6b5c96f808e01c77fa9537ab4#body_text
is schema:about of	named entity 'cell-surface' named entity 'secretion' named entity 'xylose' named entity 'protein' named entity 'infection' named entity 'protein' named entity 'immunogenicity' named entity 'porcine parvovirus' named entity 'Lactobacillus casei' named entity 'wild type' named entity 'Evans blue' named entity 'xylose' named entity 'gene' named entity 'statistically significant' named entity 'negative control' named entity 'recombinant vector' named entity 'immunogenicity' named entity 'supernate' named entity 'Western blot' named entity 'mice' named entity 'Recombinant strains' named entity 'mice' named entity 'polypeptide' named entity 'plasmid DNA' named entity 'L. casei' named entity 'immunization' named entity 'protease' named entity 'immunization' named entity 'antibodies' named entity 'food fermentation' named entity 'Parenteral' named entity 'cell surface' named entity 'gastrointestinal' named entity 'cell wall' named entity 'parvovirus' named entity 'epithelial' named entity 'immune responses' named entity 'serially diluted' named entity 'immunogenicity' named entity 'lactic acid bacteria' named entity 'parvovirus' named entity 'mice' named entity 'Western blot' named entity 'goat' named entity 'viral genome' named entity 'primers' named entity 'vaccination' named entity 'serum samples' named entity 'primary antibodies' named entity 'xylose' named entity 'infection' named entity 'thrice' named entity 'centrifuged' named entity 'sulphate' named entity 'outer membrane' named entity 'virus transmission' named entity 'PBS' named entity 'immune responses' named entity 'thrice' named entity 'signal peptide' named entity 'L. casei' named entity 'Infection' named entity 'xylose' named entity 'fusion protein' named entity 'subunit vaccines' named entity 'mice' named entity 'secretion' named entity 'antibodies' named entity 'polypeptide' named entity 'serial dilution' named entity 'mucosal immunity' named entity 'conjugated' named entity 'glucose' named entity 'vaccination' named entity 'protease' named entity 'secretion' named entity 'recombinant strains' named entity 'protein' named entity 'LAB' named entity 'immunogenicity' named entity 'L. casei' named entity 'protein'

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