About: EF1A interacting with nucleocapsid protein of transmissible gastroenteritis coronavirus and plays a role in virus replication

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An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	EF1A interacting with nucleocapsid protein of transmissible gastroenteritis coronavirus and plays a role in virus replication
Creator	Feng, Li Chen, Jianfei Shi, Da Shi, Hongyan Zhang, Xin Li, Changlong
Source	Elsevier; Medline; PMC
abstract	Transmissible gastroenteritis coronavirus (TGEV) is an enteropathogenic coronavirus that causes diarrhea in pigs, which is correlated with high morbidity and mortality in suckling piglets. Using the method of GST pull-down with the nucleocapsid (N), N protein was found to interact with swine testes (ST) cells elongation factor 1-alpha (EF1A), an essential component of the translational machinery with an important role in cells. In vitro and in virus-infected cells interaction was then confirmed by co-precipitation. Knockdown of EF1A impairs N protein proliferation and TGEV replication in host cell. It was demonstrated that EF1A plays a role in TGEV replication. The present study thus provides a protein-related information that should be useful for underlying mechanism of coronavirus replication.
has issue date	2014-08-27(xsd:dateTime)
bibo:doi	10.1016/j.vetmic.2014.05.034
bibo:pmid	24974120
has license	no-cc
sha1sum (hex)	555749866b1f567f15e4c0068658566f2bbfa4e9
schema:url	https://doi.org/10.1016/j.vetmic.2014.05.034
resource representing a document's title	EF1A interacting with nucleocapsid protein of transmissible gastroenteritis coronavirus and plays a role in virus replication
has PubMed Central identifier	PMC7117464
has PubMed identifier	24974120
schema:publication	Vet Microbiol
resource representing a document's body	covid:555749866b1f567f15e4c0068658566f2bbfa4e9#body_text
is schema:about of	named entity 'EF1A' named entity 'PLAYS' named entity 'virus' named entity 'PROTEIN ' named entity 'ROLE' named entity 'INTERACTING' named entity 'NUCLEOCAPSID PROTEIN' named entity 'VIRUS REPLICATION' named entity 'TRANSMISSIBLE GASTROENTERITIS CORONAVIRUS' named entity 'nucleocapsid protein' named entity 'transmissible gastroenteritis coronavirus' named entity 'protein' named entity 'virus' named entity 'nucleocapsid' named entity 'protein' named entity 'siRNA' named entity 'nucleocapsid' named entity 'EF1A' named entity 'GST protein' named entity 'animal cells' named entity 'protein' named entity 'nucleocapsid' named entity 'EF1A' named entity 'protein' named entity 'inoculation' named entity 'EF1A' named entity 'nucleocapsid' named entity 'EF1A' named entity 'supernatant' named entity 'IgG' named entity 'EF1A' named entity 'EF1A' named entity 'Recombinant' named entity '1:200' named entity 'mAb' named entity 'supernatant' named entity 'GST protein' named entity 'protein' named entity 'SARS-CoV' named entity 'paraformaldehyde' named entity 'mRNAs' named entity 'viral RNA' named entity 'regulating the expression' named entity 'IBV' named entity 'viral proteins' named entity 'protein' named entity 'nucleocapsid' named entity 'ubiquitin-dependent degradation' named entity 'PCR' named entity 'coronavirus' named entity 'PMSF' named entity 'Triton X-100' named entity 'nucleocapsid' named entity 'protein-protein interactions' named entity 'EF1A' named entity 'mAb' named entity 'T7 polymerase' named entity 'TGEV' named entity 'protein' named entity 'RNA genome' named entity 'replicase' named entity 'pleiotropic' named entity 'genus' named entity 'protein' named entity 'nucleocapsid' named entity 'EF1A' named entity 'protease inhibitor' named entity 'siRNA' named entity 'NaCl' named entity 'protein expression' named entity 'TGEV' named entity 'virus' named entity 'TGEV' named entity 'EF1A' named entity 'transcription' named entity 'host cells'

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