About: The Impact of Ambient Environmental Exposures to Microbial Products on Asthma Outcomes from Birth to Childhood

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About: The Impact of Ambient Environmental Exposures to Microbial Products on Asthma Outcomes from Birth to Childhood Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	The Impact of Ambient Environmental Exposures to Microbial Products on Asthma Outcomes from Birth to Childhood
Creator	Guthrie, Barbara Howard, Evin Huang, Lisa Orhurhu, Vwaire Phipatanakul, Wanda
Source	Medline; PMC
abstract	PURPOSE OF REVIEW: Asthma is a chronic respiratory condition with increasing domestic and worldwide prevalence that burdens individuals and the healthcare system with high costs associated with long-term treatments and acute emergency room (ER) visits. It can be triggered by ambient microbes, including bacteria, viruses, and fungi. In this review, we examine the outcomes of asthma patients in relation to environmental exposures to ambient microbe products, focusing on whether exposure leads to asthma development from birth to childhood and if particular microbes are associated with worsened asthma exacerbations. RECENT FINDINGS: Bacterial endotoxin is more prominent in homes with pets and may cause cytokine cascades that lead to asthma exacerbation. However, some studies have demonstrated a protective effect with early exposure. Patients with positive Aspergillus skin testing are more prone to moderate-severe or severe-uncontrolled asthma. Fungal sensitization is also associated with earlier onset of asthma and demonstrates a dose-dependent relationship of symptom severity and duration. Among viruses, rhinovirus has the greatest association with decreased lung function, severe asthma, and asthma-related hospital admissions. Distribution of microbial products and associated asthma symptoms depends on the geographical climate. Genetic variations among individuals also mitigate the effects of microbial products on asthma development and symptom severity. SUMMARY: Microbial products of bacteria, fungi, and viruses are associated with the development of asthma, more severe asthma symptoms, and worse outcomes. However, some early exposure studies have also demonstrated a protective effect. Bacterial and fungal products are related to decreased lung function and earlier onset of asthma. Viral products are related to asthma-associated hospital admissions; and the climate and patient genetics can also temper or intensify the relationships between microbial products, asthma development, and asthma symptom severity. Further research should focus on the effects of early microbe exposure and its interaction with human immune systems and asthma-related outcomes.
has issue date	2019-11-28(xsd:dateTime)
bibo:doi	10.1007/s11882-019-0890-2
bibo:pmid	31781873
has license	no-cc
sha1sum (hex)	5562c2dfbebce46e0c95827c8840ad0b861666e3
schema:url	https://doi.org/10.1007/s11882-019-0890-2
resource representing a document's title	The Impact of Ambient Environmental Exposures to Microbial Products on Asthma Outcomes from Birth to Childhood
has PubMed Central identifier	PMC7088961
has PubMed identifier	31781873
schema:publication	Curr Allergy Asthma Rep
resource representing a document's body	covid:5562c2dfbebce46e0c95827c8840ad0b861666e3#body_text
is schema:about of	named entity 'AMBIENT' named entity 'MICROBIAL' covid:arg/5562c2dfbebce46e0c95827c8840ad0b861666e3 named entity 'LEADS' named entity 'HEALTHCARE SYSTEM' named entity 'CHRONIC' named entity 'ASTHMA' named entity 'RHINOVIRUS' named entity 'HUMAN' named entity 'RESEARCH' named entity 'CYTOKINE ' named entity 'PROMINENT' named entity 'PRODUCTS' named entity 'BACTERIA' named entity 'EXPOSURE' named entity 'IMMUNE SYSTEMS' named entity 'RECENT' named entity 'VIRUSES' named entity 'DURATION' named entity 'FINDINGS' named entity 'VISITS' named entity 'WORSE' named entity 'ASPERGILLUS' named entity 'UNCONTROLLED' named entity 'PATIENT' named entity 'TRIGGERED BY' named entity 'CAUSE' named entity 'FOCUSING' named entity 'RELATIONSHIPS' named entity 'FOCUS' named entity 'MICROBE' named entity 'LEAD' named entity 'CLIMATE' named entity 'HAVE' named entity 'RESPIRATORY CONDITION' named entity 'HOSPITAL ADMISSIONS' named entity 'CHILDHOOD' named entity 'PREVALENCE' named entity 'IS A' named entity 'EARLIER' named entity 'MICROBIAL' named entity 'REVIEW' named entity 'ENVIRONMENTAL EXPOSURES' named entity 'PRODUCTS' named entity 'FROM BIRTH' named entity 'DECREASED LUNG FUNCTION' named entity 'PARTICULAR' named entity 'OUTCOMES' named entity 'DOMESTIC' named entity 'BACTERIAL ENDOTOXIN' named entity 'ACUTE' named entity 'OUTCOMES' named entity 'CHILDHOOD' named entity 'INDIVIDUALS' named entity 'PRONE' named entity 'GEOGRAPHICAL' named entity 'DOSE-DEPENDENT' named entity 'DEVELOPMENT' named entity 'SYMPTOMS' named entity 'SYMPTOM SEVERITY' named entity 'ITS' named entity 'SEVERE ASTHMA' named entity 'ONSET OF' named entity 'COSTS' named entity 'SEVERE' named entity 'BACTERIAL' named entity 'FUNGI' named entity 'IMPACT' named entity 'HIGH' named entity 'PURPOSE' named entity 'EARLY' named entity 'SKIN TESTING' named entity 'GENETIC VARIATIONS' named entity 'DEMONSTRATED' named entity 'ASSOCIATED' named entity 'FROM BIRTH' named entity 'PATIENTS'

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