About: Separation and Quantification of Four Main Chiral Glucosinolates in Radix Isatidis and Its Granules Using High-Performance Liquid Chromatography/Diode Array Detector Coupled with Circular Dichroism Detection

Facets (new session)
Description
Metadata
Settings
- owl:sameAs
- Inference Rule:

About: Separation and Quantification of Four Main Chiral Glucosinolates in Radix Isatidis and Its Granules Using High-Performance Liquid Chromatography/Diode Array Detector Coupled with Circular Dichroism Detection Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Separation and Quantification of Four Main Chiral Glucosinolates in Radix Isatidis and Its Granules Using High-Performance Liquid Chromatography/Diode Array Detector Coupled with Circular Dichroism Detection
Creator	Wang, Rui Yang, Li Li, Jinhang Shi, Yanhong Wang, Zhengtao Zheng, Cheng
Source	Medline; PMC
abstract	As chemical drugs, separation and quantification of the specific enantiomer from the chiral compounds in herbal medicines are becoming more important. To clarify the chemical characterization of chiral glucosinolates—the antiviral active ingredients of Radix Isatidis, an optimized efficient method of HPLC-UV-CD was developed to simultaneously separate and quantify the four main chiral glucosinolates: progoitrin, epiprogoitrin, and R,S-goitrin. The first step was to determine progoitrin, epiprogoitrin, and R,S-goitrin using HPLC-UV, and then determine the R-goitrin and S-goitrin by coupling with CD detection. Subsequently, through the linear relations between anisotropy factor (g factor) and the percent optical purity of R-goitrin, the contents of R-goitrin and S-goitrin from the R,S-goitrin mixture were calculated separately. Furthermore, the chemical composition features of the four chiral glucosinolates in 37 samples from crude drugs, decoction pieces, and granules of R. Isatidis were conducted. The total content of the four glucosinolates was obviously higher in crude drugs, and the variance character of each glucosinolate contents was different. In summary, the accurate measurement method reported here allows for better control of the internal quality of R. Isatidis and its granules and provides a powerful approach for the analysis of other chiral components in traditional Chinese medicines.
has issue date	2018-05-29(xsd:dateTime)
bibo:doi	10.3390/molecules23061305
bibo:pmid	29844266
has license	cc-by
sha1sum (hex)	5676dd53889b4c43a772e163763ee7f1525f98da
schema:url	https://doi.org/10.3390/molecules23061305
resource representing a document's title	Separation and Quantification of Four Main Chiral Glucosinolates in Radix Isatidis and Its Granules Using High-Performance Liquid Chromatography/Diode Array Detector Coupled with Circular Dichroism Detection
has PubMed Central identifier	PMC6100438
has PubMed identifier	29844266
schema:publication	Molecules
resource representing a document's body	covid:5676dd53889b4c43a772e163763ee7f1525f98da#body_text
is schema:about of	named entity 'GRANULES' named entity 'quantify' named entity 'traditional Chinese medicines' named entity 'powerful' named entity 'drugs' named entity 'molecules' named entity 'Array' named entity 'MOLECULES' named entity 'SEPARATION' named entity 'MAIN' named entity 'ARRAY DETECTOR' named entity 'USING' named entity 'CHARACTER' named entity 'CIRCULAR DICHROISM' named entity 'ITS' named entity 'EFFICIENT' named entity 'ANISOTROPY' named entity 'QUALITY' named entity 'SEPARATE' named entity 'LINEAR' named entity 'OF EACH' named entity 'SPECIFIC' named entity 'REPORTED' named entity 'APPROACH' named entity '28G' named entity 'DRUGS' named entity 'CLARIFY' named entity 'ENANTIOMER' named entity 'HPLC-UV' named entity 'HIGHER' named entity 'FEATURES' named entity 'MIXTURE' named entity 'GLUCOSINOLATES' named entity 'GLUCOSINOLATE' named entity 'ANALYSIS' named entity 'DECOCTION PIECES' named entity 'CHINESE MEDICINES' named entity 'RELATIONS' named entity 'METHOD' named entity 'DETECTION' named entity 'RADIX ISATIDIS' named entity 'CHIRAL' named entity 'COUPLED' named entity 'MAIN' named entity 'TOTAL' named entity 'CONTROL' named entity 'BETTER' named entity 'GRANULES' named entity 'GOITRIN' named entity 'USING' named entity 'CONTENTS' named entity 'ALLOWS' named entity 'CONTENT' named entity 'RADIX ISATIDIS' named entity 'SIMULTANEOUSLY' named entity 'EPIPROGOITRIN' named entity 'DETERMINE' named entity 'INTERNAL' named entity 'ANTIVIRAL' named entity 'HERBAL MEDICINES' named entity 'QUANTIFICATION' named entity 'FIRST STEP' named entity 'DIFFERENT' named entity 'CHIRAL' named entity 'COMPONENTS' named entity 'IMPORTANT' named entity 'SEPARATION' named entity 'PROVIDES' named entity 'MEASUREMENT METHOD' named entity 'FACTOR' named entity 'VARIANCE' named entity 'ACTIVE INGREDIENTS' named entity 'PROGOITRIN' named entity 'GLUCOSINOLATES' named entity 'CALCULATED' named entity 'OPTICAL'

Faceted Search & Find service v1.13.91 as of Mar 24 2020

Alternative Linked Data Documents: Sponger | ODE Content Formats:

RDF

ODATA

Microdata

About

OpenLink Virtuoso version 07.20.3229 as of Jul 10 2020, on Linux (x86_64-pc-linux-gnu), Single-Server Edition (94 GB total memory)
Data on this page belongs to its respective rights holders.
Virtuoso Faceted Browser Copyright © 2009-2024 OpenLink Software